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A Narrative Review of Repository Corticotropin Injection for the Treatment of Systemic Lupus Erythematosus.

Author: AskanaseAnca D, FurieRichard A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This review examines the efficacy and safety of repository corticotropin injection (RCI) for treating systemic lupus erythematosus (SLE) flares. Data from three clinical trials suggest that RCI improves global disease activity scores and SLE clinical manifestations, with an acceptable safety profile.
Paper Details　
Original Abstract of the Article :
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects multiple organ systems. The most prevalent manifestations include constitutional symptoms, arthritis, and rash. An SLE flare is defined as a measurable increase in disease activity that may prompt a change in treatment....See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239929/

データ提供：米国国立医学図書館（NLM）

Repository Corticotropin Injection: A New Oasis for Refractory Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder that affects various organs, creating a desert of discomfort for patients. This research delves into the potential benefits of repository corticotropin injection (RCI) as a treatment for refractory SLE. By reviewing data from clinical trials, the authors highlight RCI's positive impact on global disease activity scores and specific SLE manifestations. They emphasize RCI's favorable safety profile and discuss its distinct mechanism of action, suggesting it could be a valuable addition to the treatment landscape for SLE.

Repository Corticotropin Injection: A New Oasis for Refractory Systemic Lupus Erythematosus

RCI demonstrates promising efficacy in treating patients with moderate-severe refractory SLE. The pooled data from three clinical trials show a significant improvement in the BILAG-2004 index scores and joint counts after 8 and 4 weeks of treatment, respectively. This indicates that RCI has the potential to effectively manage SLE flares and improve quality of life for patients.

Repository Corticotropin Injection: A New Oasis for Refractory Systemic Lupus Erythematosus

This research underscores the importance of finding alternative treatment options for patients with refractory SLE. RCI offers a potential oasis in the desert of SLE, providing a safe and effective treatment option that could significantly improve the lives of those affected by this complex condition. The study highlights the potential of RCI to reduce disease activity and flares, offering a path towards better symptom management and potentially improved long-term outcomes.

Dr.Camel's Conclusion

This research provides valuable evidence for the potential of RCI as a treatment option for patients with refractory SLE. The distinct mechanisms of action and favorable safety profile of RCI make it a promising therapeutic tool. It offers a beacon of hope in the vast desert of SLE, providing a potential path towards improved disease management and better quality of life for patients.

Date :
  1. Date Completed 2022-06-30
  2. Date Revised 2022-09-06
Further Info :

Pubmed ID

35641860

DOI: Digital Object Identifier

PMC9239929

Related Literature

Article Analysis
・Effects of corticotropin repository injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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