Effects of corticotropin repository injection: A Synthesis of Findings from 17 Studies

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Original Abstract of the Article

Main Research Findings

Repository corticotropin injection (RCI) has been studied for its potential therapeutic effects in various autoimmune and inflammatory diseases. Research suggests that RCI could be an effective treatment for conditions like pulmonary sarcoidosis, cutaneous dermatomyositis, multiple sclerosis, systemic lupus erythematosus, and myositis. 10 、 1 、 11 、 7 、 6 RCI is a complex mixture of adrenocorticotropic hormone (ACTH) analogs and other pituitary peptides. These compounds exert anti-inflammatory and immunomodulatory effects, which might contribute to its efficacy in treating these conditions. 10 Additionally, RCI has shown potential for reducing the need for traditional steroid therapies, suggesting steroid-sparing properties. 10 However, the effectiveness and safety of RCI remain under investigation, and further research is necessary to fully understand its potential benefits and risks.

Benefits and Risks

Benefit Summary

RCI has shown promise as a treatment for a range of autoimmune and inflammatory conditions, including pulmonary sarcoidosis, cutaneous dermatomyositis, multiple sclerosis, systemic lupus erythematosus, and myositis. 10 、 1 、 11 、 7 、 6 Moreover, RCI has demonstrated potential for reducing the need for long-term steroid therapies, which can have significant side effects. 10

Risk Summary

While RCI holds potential benefits, it's important to note that it also carries risks. Potential side effects of RCI can include gastrointestinal issues, weight gain, hypertension, increased blood sugar levels, and an elevated risk of infections. 12 Additionally, RCI is a relatively expensive treatment, raising concerns about cost-effectiveness. 12

Comparison Between Studies

Commonalities

Several studies consistently suggest that RCI holds potential as a treatment for various autoimmune and inflammatory conditions. 10 、 1 、 11 、 7 、 6 Furthermore, research consistently points to RCI's potential for reducing the need for traditional steroid therapies. 10 The studies also acknowledge the need for further research to better understand the effectiveness and safety of RCI.

Differences

While various studies have explored RCI's effects, there are differences in study design, target conditions, evaluation methods, and outcomes, making it crucial to interpret findings with caution when attempting to draw comprehensive conclusions.

Consistency and Contradictions in Results

Several research studies suggest that RCI has potential for treating autoimmune and inflammatory conditions, however, conclusive evidence regarding its effectiveness and safety is still lacking. The high cost of RCI also raises concerns about its cost-effectiveness. 12 Therefore, further investigation is necessary to fully understand the clinical utility of RCI.

Practical Implications and Considerations

While RCI shows promise for autoimmune and inflammatory conditions, it's important to remember that it also carries risks. The high cost of RCI must also be taken into account when considering its use. Before deciding on RCI treatment, it's essential to consult with your doctor to fully discuss the potential benefits, risks, and cost-effectiveness of this therapy.

Limitations of Current Research

Further research is needed to better understand the effectiveness and safety of RCI. Specifically, studies focusing on long-term effects and side effects of RCI are crucial. Additionally, research addressing the cost-effectiveness of RCI is essential to inform clinical decision-making.

Future Research Directions

To fully assess the value of RCI as a treatment option, future research should prioritize long-term studies to evaluate its effectiveness and safety over extended periods. Additionally, research is needed to address the cost-effectiveness of RCI, comparing it to other available treatment options.

Conclusion

RCI has shown potential as a treatment for various autoimmune and inflammatory diseases, but its effectiveness and safety require further investigation. The high cost of RCI must also be taken into consideration when considering its use. While it shows promise, more research is needed to fully understand its potential benefits and risks before it can be widely recommended as a treatment option.

Literature analysis of 17 papers
Positive Content
16
Neutral Content
0
Negative Content
1
Article Type
2
0
0
4
16
2.

Treatment modalities for infantile spasms: current considerations and evolving strategies in clinical practice.

Author: HollensheadPayton P, JacksonCorrie N, CrossJordan V, WittenTaylor E, AnwarAhmed I, AhmadzadehShahab, ShekoohiSahar, KayeAlan D

IESS treatment

Infantile spasms, now known as infantile epileptic spasm syndrome (IESS), are a serious seizure disorder in infants. This paper reviews different treatment options for IESS, including ACTH, Acthar Gel, corticosteroids, valproic acid, vigabatrin, and surgery, with a focus on the efficacy and safety of Acthar Gel.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Corticosteroid Use and Adherence in Patients Treated with Acthar Gel for Advanced Sarcoidosis.

Author: HayesKyle, NiewoehnerJohn, RiceJ Bradford, DownesNathaniel, HagopianElla, MaIzzy, WanGeorge J

Steroid-sparing effect

Long-term corticosteroid use is associated with adverse events and worsened quality of life. This study compared the corticosteroid-sparing effects of Acthar Gel, a repository corticotropin injection, with other treatments for sarcoidosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Results From a Phase 4, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Repository Corticotropin Injection for the Treatment of Pulmonary Sarcoidosis.

Author: MirsaeidiMehdi, BaughmanRobert P, SahooDebasis, TarauEva

Sarcoidosis treatment
Glucocorticoid toxicity

This study evaluated the efficacy and safety of repository corticotropin injection (RCI) in patients with pulmonary sarcoidosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Acthar Gel Inhibits the Activation of CD4<sup>+</sup> and CD8<sup>+</sup> T Cells.

Author: WrightDale, HayesKyle

Anti-inflammatory
Reduced T cell activation

This study compares the effects of Acthar, synthetic ACTH1-24 depot, and prednisolone on T cell activation in a murine model. Acthar significantly reduced the number of activated T cells and cytokine production, suggesting a distinct immunomodulatory effect on T cells compared to the other treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

A Narrative Review of Repository Corticotropin Injection for the Treatment of Systemic Lupus Erythematosus.

Author: AskanaseAnca D, FurieRichard A

Improved SLE activity
Reduced SLE flares
Few serious adverse events

This review examines the efficacy and safety of repository corticotropin injection (RCI) for treating systemic lupus erythematosus (SLE) flares. Data from three clinical trials suggest that RCI improves global disease activity scores and SLE clinical manifestations, with an acceptable safety profile.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Effects of Subcutaneous Repository Corticotropin Gel Injection on Regulatory T Cell Population in Noninfectious Retinal Vasculitis.

Author: AnesiStephen D, ChangPeter Y, MalekiArash, ManhapraAmbika, Look-WhySydney, AsgariSoheila, WalshMarisa, DrenenKayla, FosterC Stephen

Complementary treatment

This prospective nonrandomized open-label study evaluated the effect of repository corticotropin injection (RCI) on regulatory T cell population in patients with noninfectious retinal vasculitis. RCI may be a complementary treatment, but the study did not demonstrate an increase in regulatory T cell population.

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Repository Corticotropin Injection for the Treatment of Pulmonary Sarcoidosis: A Narrative Review.

Author: MirsaeidiMehdi, BaughmanRobert P

Pulmonary sarcoidosis treatment
Steroid-sparing

This narrative review examines the clinical evidence for the safety and efficacy of repository corticotropin injection (RCI) in the treatment of pulmonary sarcoidosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Results from a multicenter, randomized, double-blind, placebo-controlled study of repository corticotropin injection for multiple sclerosis relapse that did not adequately respond to corticosteroids.

Author: WynnDaniel, GoldstickLawrence, BauerWilliam, ZhaoEnxu, TarauEva, CohenJeffrey A, RobertsonDerrick, MillerAaron

MS relapse treatment

About 20-35% of multiple sclerosis (MS) patients do not respond well to high-dose corticosteroids during a relapse. This article introduces repository corticotropin injection (RCI, Acthar Gel), a naturally sourced complex mixture of adrenocorticotropic hormone analogs and pituitary peptides, which has potential anti-inflammatory and immunomodulatory effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Treatment of Noninfectious Retinal Vasculitis Using Subcutaneous Repository Corticotropin Injection.

Author: AnesiStephen D, ChangPeter Y, MalekiArash, StephensonAndrew, MontiethAlyssa, FilipowiczArtur, SyedaSarah, AsgariSoheila, WalshMarisa, MetzingerJamie Lynne, FosterC Stephen

Retinal vasculitis treatment

This case series found that repository corticotropin injection was well tolerated and may be an effective treatment for noninfectious retinal vasculitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Comparison of Steroidogenic Exposure Following the Administration of Repository Corticotropin Injection With a Synthetic ACTH<sub>1-24</sub> Depot and Methylprednisolone in Healthy Subjects.

Author: WangXiaofeng, PhamLoan, PoolaNagaraju, BrooksLeah R, DueBryan

ACTH treatment
Corticotropin comparison

This study compared the steroidogenic exposure of repository corticotropin injection and synthetic ACTH<sub>1-24</sub> depot in healthy adults. The results show that synthetic ACTH<sub>1-24</sub> depot has a substantially higher steroidogenic exposure than repository corticotropin injection at clinically relevant doses.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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