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Glucocorticoid-induced expansion of classical monocytes contributes to bone loss.

Author: GaoJunjie, GaoYoushui, GuoShang, LiuFuyun, LiuPei, LuoPengbo, WangShengdian, XuJianzhong, YuHongping, ZhangChangqing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that classical monocytes play a crucial role in high-dose exogenous glucocorticoid-induced osteoporosis (GIOP) by mediating osteoclastogenesis. Deletion of classical monocytes prevented GIOP via inhibition of osteoclastogenesis and restoration of CD31<sup>Hi</sup>endomucin<sup>Hi</sup> vessels.
Paper Details　
Original Abstract of the Article :
Classical monocytes are commonly involved in the innate inflammatory response and are the progenitors of osteoclasts. Excess endogenous glucocorticoids (GCs) can increase the levels of classical monocytes in blood and bone marrow. The role of this cell population in high-dose exogenous GC-induced os...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256622/

データ提供：米国国立医学図書館（NLM）

Glucocorticoid-Induced Osteoporosis: A Camel's Journey Through the Bones

This research delves into the intricate relationship between glucocorticoids and bone loss, a significant concern in patients receiving prolonged steroid therapy. The study investigates the role of classical monocytes in glucocorticoid-induced osteoporosis (GIOP), a condition characterized by accelerated bone loss. The authors meticulously analyzed the effects of glucocorticoids on classical monocyte populations, exploring their contribution to osteoclastogenesis and bone resorption.

A Desert Storm of Bone Loss: Glucocorticoids and Osteoclasts

The study reveals a crucial link between glucocorticoids, classical monocytes, and bone loss. The authors demonstrate that glucocorticoid treatment increases the number of classical monocytes in bone marrow, leading to enhanced osteoclastogenesis and bone resorption. It's like a desert storm that erodes the landscape: glucocorticoids create an environment that promotes the formation of osteoclasts, the cells responsible for breaking down bone.

Navigating the Oasis of Bone Health: A Camel's Perspective

This research highlights the importance of understanding the mechanisms underlying glucocorticoid-induced osteoporosis. The study's findings provide insights into the role of classical monocytes in bone loss, suggesting potential targets for therapeutic interventions. It's like finding a hidden oasis in the desert: discovering the underlying mechanisms of GIOP can lead to new strategies for preserving bone health and preventing fractures.

Dr.Camel's Conclusion

This study sheds light on the role of classical monocytes in glucocorticoid-induced osteoporosis, providing valuable insights into the mechanisms underlying bone loss. It encourages further investigation into potential therapeutic strategies that target classical monocytes, potentially offering new avenues for preventing and treating GIOP and preserving bone health.

Date :
  1. Date Completed 2022-07-08
  2. Date Revised 2022-11-13
Further Info :

Pubmed ID

35672449

DOI: Digital Object Identifier

PMC9256622

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English

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