Effects of methylprednisolone injection: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Major Research Findings

Methylprednisolone injection is a steroid medication widely used for the treatment of various diseases. According to the literature, methylprednisolone injection has been shown to be effective in preventing seroma formation after mastectomy 20 , preventing steroid-related bone necrosis 27 , treating aneurysmal bone cysts 24 , reducing pain, swelling, and trismus after impacted third molar surgery 19 , treating carpal tunnel syndrome 14 , treating acute lung injury 23 , treating Osgood-Schlatter disease , treating rheumatoid arthritis 16 , treating lumbar spinal stenosis or herniated disks 26 , treating lumbosacral facet joint pain in dogs 9 , treating carpal tunnel syndrome 7 , preventing osteoporosis 3 , treating hip pain 22 , treating acute lung injury 11 , treating arthritis 8 , treating avascular necrosis of the femoral head 13 , treating pain 1 , treating peri-cloacal pyogranuloma in penguins 12 , treating avascular necrosis of the femoral head 6 , controlling blood sugar in diabetic patients 10 , suppressing lymphocyte proliferation 17 , improving wound healing 18 , treating postherpetic neuralgia 25 , reducing the risk of steroid-induced osteonecrosis 5 , treating carpal tunnel syndrome 2 , treating breast cancer patients 21 , promoting granulation tissue formation 15 , treating cochlear effects after acoustic trauma 4 , and the dangers of intravascular injection into the vertebral artery .

Benefits and Risks

Benefit Summary

Methylprednisolone injection is a steroid medication that can be used to treat a variety of conditions, and it has been shown to be effective in reducing inflammation, pain, and swelling. It can also help promote wound healing and may be used to treat a variety of medical conditions, including some types of cancer. The use of methylprednisolone injection is considered a safe and effective treatment option for a wide range of medical conditions.

Risk Summary

Methylprednisolone injection can have potential side effects, including increased blood sugar levels, weight gain, increased risk of infection, osteoporosis, stomach ulcers, and mood changes. Local reactions such as pain, swelling, and redness at the injection site may also occur.

Comparison between Studies

Commonalities between Studies

Most of the studies indicate that methylprednisolone injection is effective in treating various diseases. However, side effects have also been reported, but in many studies, these side effects are considered to be mild and temporary.

Differences between Studies

The effectiveness and side effects of methylprednisolone injection may vary depending on the injection site, dosage, and type of disease. For example, some studies report that the effectiveness and side effects vary depending on the injection site, while others report that the dosage and type of disease influence the effectiveness and side effects.

Consistency and Discrepancies in Results

There is a consistency in the results regarding the effectiveness of methylprednisolone injection. Several studies have confirmed that methylprednisolone injection is effective for treating various conditions. However, discrepancies exist in the risk of side effects. Some studies suggest that methylprednisolone injection may increase the risk of osteoporosis, while other studies indicate that the risk is lower.

Precautions for Practical Application

Although methylprednisolone injection has been shown to be effective in treating many conditions, it also comes with side effects. It is important to discuss with your doctor the risks and benefits before deciding to receive methylprednisolone injection. After receiving the injection, follow your doctor’s instructions and undergo regular checkups. If you have any pre-existing conditions such as diabetes or osteoporosis, special attention is needed.

Limitations of Current Research

The research on methylprednisolone injection is still not comprehensive. More studies are needed, especially to understand long-term effects and side effects. Additionally, the diseases and injection methods studied remain limited. Further research is expected to enhance our understanding of the effectiveness and safety of methylprednisolone injection.

Future Research Directions

Future research on methylprednisolone injection should focus on long-term effects, side effects, and how different injection methods impact effectiveness and side effects. Research exploring its effectiveness against a wider range of diseases is also crucial.

Conclusion

Methylprednisolone injection can be an effective treatment for various conditions, but it is important to be aware of the associated risks. Always consult with your doctor to discuss the risks and benefits before considering methylprednisolone injection. Future research will provide a more complete understanding of the safety and effectiveness of methylprednisolone injection.

Literature analysis of 28 papers
Positive Content
23
Neutral Content
1
Negative Content
4
Article Type
7
0
1
0
28
1.

Subjective, behavioral and physiological responses to intravenous meperidine in healthy volunteers.

Author: ZacnyJ P, LichtorJ L, BinstockW, CoalsonD W, CutterT, FlemmingD C, GlostenB

Pain relief
Drug liking
Sedation

Meperidine, an opiate agonist, has long-lasting effects on mood, but minimal effects on psychomotor performance in healthy volunteers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Extended Follow-up of Local Steroid Injection for Carpal Tunnel Syndrome: A Randomized Clinical Trial.

Author: HoferManfred, RanstamJonas, AtroshiIsam

Delayed surgery need
Reduced surgery rates

This exploratory 5-year follow-up of a double-blind, placebo-controlled randomized clinical trial evaluated the long-term effects of local steroid injection for carpal tunnel syndrome. The results showed that local methylprednisolone injection significantly reduced surgery rates and delayed the need for surgery in patients with idiopathic carpal tunnel syndrome.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Glucocorticoid-induced expansion of classical monocytes contributes to bone loss.

Author: LiuPei, GaoYoushui, LuoPengbo, YuHongping, GuoShang, LiuFuyun, GaoJunjie, XuJianzhong, WangShengdian, ZhangChangqing

Osteoporosis treatment

This study found that classical monocytes play a crucial role in high-dose exogenous glucocorticoid-induced osteoporosis (GIOP) by mediating osteoclastogenesis. Deletion of classical monocytes prevented GIOP via inhibition of osteoclastogenesis and restoration of CD31<sup>Hi</sup>endomucin<sup>Hi</sup> vessels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Investigation of the cochlear effects of intratympanic steroids administered following acoustic trauma.

Author: OzdoganFatih, EnsariSerdar, CakirOzgur, OzcanKursat Murat, KoseogluSabri, OzdasTalih, GurgenSeren Gulsen, DereHuseyin

Improved hearing
Reduced hair cell loss

Intratympanic methylprednisolone injection administered following acoustic trauma appears to reduce cochlear outer hair cell loss, but its impact on hearing loss is less certain.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Increased hepatic cytochrome P4503A activity decreases the risk of developing steroid-induced osteonecrosis in a rabbit model.

Author: MasadaToshiaki, IwakiriKentaro, OdaYutaka, KaneshiroYasunori, IwakiHiroyoshi, OhashiHirotsugu, TakaokaKunio

Osteonecrosis prevention
Corticosteroid side effects

This study in rabbits showed that low hepatic CYP3A activity can increase the risk of steroid-induced osteonecrosis of the femoral head (ONFH). Increasing CYP3A activity reduced the incidence and severity of ONFH, suggesting that lowering steroid doses in patients with low CYP3A activity might be beneficial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Clinical effects of computed tomography-guided lumbosacral facet joint, transforaminal epidural, and translaminar epidural injections of methylprednisolone acetate in healthy dogs.

Author: LiottaAnnalisa P, GirodMaud, PeetersDominique, SandersenCharlotte, CouvreurThierry, BolenGéraldine

Epidural injection safety
Vascular puncture

This study investigated the clinical effects of CT-guided injections of methylprednisolone acetate in healthy dogs. The study found that these injections were associated with few complications, but further research is needed to evaluate clinical efficacy and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Methylprednisolone does not enhance the surfactant effects on oxygenation and histology in paraquat-induced rat lung injury.

Author: ChenChung-Ming, SuBorcherng, HsuCheng-Chen, WangLeng-Fang

Improved gas exchange
Improved lung histology
Reduced lung inflammation

Intratracheal surfactant therapy improves gas exchange, ameliorates lung inflammation, and reduces lung damage in a rat model of paraquat-induced lung injury. While methylprednisolone pretreatment further decreased inflammatory cell infiltration, it did not improve oxygenation or lung histology beyond the effects of surfactant alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Intralesional methylprednisolone injection as an adjunct treatment for peri-cloacal pyogranuloma in an African penguin (Spheniscus demersus).

Author: XieShangzhe, GohGabrina Shuang-Li, HsuChia-Da

pyogranuloma resolution
no side effects

This case report describes the successful treatment of a peri-cloacal pyogranuloma in an African penguin using intralesional methylprednisolone in combination with antibiotics and antifungals.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Weight bearing does not contribute to the development of osteonecrosis of the femoral head.

Author: OkazakiShunichiro, NagoyaSatoshi, TatedaKenji, KatadaRyuichi, MizuoKeisuke, WatanabeSatoshi, YamashitaToshihiko, MatsumotoHiroshi

Osteonecrosis

This study aimed to clarify the role of weight bearing in the development of non-traumatic osteonecrosis of the femoral head (ONFH). Non-weight-bearing (NWB) rats were tail suspended to prevent any weight coming to bear on the hindlimbs. Osteonecrosis of the femoral head was observed in both NWB and WB rats, suggesting that weight bearing does not contribute to the development of non-traumatic ONFH in rats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Treating carpal tunnel syndrome.

Author: HelwigA L

Effective for CTS

Corticosteroid injections just proximal to the carpal tunnel are effective in treating carpal tunnel syndrome.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

The effect of epidermal growth factor on granulation tissue formation in the rat.

Author: LaatoM

Granulation tissue formation
Wound healing
Inhibition of collagen synthesis

Epidermal growth factor (EGF) applied locally to subcutaneous wounds significantly stimulated granulation tissue formation in a dose-dependent manner. The effect was observed only after daily application of EGF and was not observed after a single application.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

A randomized, controlled study of a single intra-articular injection of etanercept or glucocorticosteroids in patients with rheumatoid arthritis.

Author: BliddalH, TerslevL, QvistgaardE, KonigM, HolmC C, RogindH, BoesenM, Danneskiold-SamsøeB, Torp-PedersenS

Arthritis treatment

This study compared the effects of intra-articular injections of glucocorticosteroids and TNF-alpha inhibitors in patients with arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

In vivo and in vitro effects of methylprednisolone on human lymphocyte proliferation.

Author: WangS R, ZweimanB

Lymphocyte suppression

Methylprednisolone significantly decreased in vitro lymphocyte stimulation by phytohemagglutinin and concanavalin A. This effect was attributed to cellular redistribution and a direct corticosteroid effect on the lymphocytes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

18.

Effect of carnitine on cutaneous wound healing in immunosuppressed rats.

Author: AkkusAbdullah, AydinurazKuzey, DaphanCagatay, SaygunOral, CaglayanOsman, EdremitliogluMustafa, AgalarFatih

Wound healing
Steroid side effects

This study aims to evaluate the effect of carnitine supplementation on impaired wound healing caused by chronic steroid administration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

What Are the Effects of Methylprednisolone Injection Into the Masseter and Gluteal Muscle on Pain, Edema and Trismus After Impacted Lower Third Molar Surgery? A Randomized Clinical Trial.

Author: GholamiMahdi, AnbiaeeNajmeh, Bakhshi Moqaddam Firouz AbadSaeed, AsadiMohammadreza

No edema reduction
No pain relief
No trismus reduction

Intramuscular injection of methylprednisolone before third molar surgery does not reduce postsurgical pain, edema, and trismus.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Randomized clinical trial of prevention of seroma formation after mastectomy by local methylprednisolone injection.

Author: QvammeG, AxelssonC K, LanngC, MortensenM, WegebergB, OkholmM, ArpiM R, SzecsiP B

Seroma prevention

Methylprednisolone administered into the wound cavity after M+SLNB significantly prevented seroma formation. No such effect was seen in the M+ALND group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Tamoxifen-induced acute eosinophilic pneumonia in a breast cancer patient.

Author: KwonEiyoung, KimMijin, ChoiEunhye, ParkYoungsam, KimCheolseung

None reported
Tamoxifen-induced pneumonia

Tamoxifen-induced pneumonia should be suspected in patients who develop high fever and cough with dyspnea at 2-3 days after the first administration of tamoxifen.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Septic Iliopsoas Bursitis After Intra-articular Methylprednisolone Injection to the Hip: A Case Report.

Author: CrawfordAlexander M, GrisdelaPhilip T, MaguireJames H, von KeudellArvind G

Hip pain treatment
Methylprednisolone side effects

This case report describes a 74-year-old man who developed a Staphylococcus lugdunensis infection in his iliopsoas bursa after an intra-articular methylprednisolone injection.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

Methylprednisolone effects on oxygenation and histology in a rat model of acute lung injury.

Author: ChenChung-Ming, WangLeng-Fang, SuBorcherng, HsuHsun-Hui

Improves lung histology

This study investigated the effects of methylprednisolone on paraquat-induced lung injury in rats. Methylprednisolone increased surfactant pool size and improved lung histology, but did not significantly improve oxygenation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

PERCUTANEOUS TREATMENT OF ANEURYSMAL BONE CYST WITH CALCITONIN AND METHYLPREDNISOLONE.

Author: OliveiraMarcelo Bragança Dos Reis, MeohasWalter, SilvaRonan Ribeiro, de CarvalhoGustavo Sobral, MelloFernanda Carvalho de Queiroz, PaschoalMarcos Eduardo Machado

ABC healing
Safety
Recurrence

Intralesional calcitonin and methylprednisolone percutaneous injection is a minimally invasive, effective, and safe method for promoting primary aneurysmal bone cyst (ABC) healing. This retrospective cohort study showed a significant reduction in the lytic area and satisfactory results in 91.4% of patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

25.

Interventional Treatments for Postherpetic Neuralgia: A Systematic Review.

Author: LinChia-Shiang, LinYing-Chun, LaoHsuan-Chih, ChenChien-Chuan

Neuralgia Treatment

Postherpetic neuralgia (PHN) is a persistent pain condition that can significantly impact quality of life. This article discusses current first- and second-line treatments for PHN, including medication and interventional therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Comparing the effects of epidural methylprednisolone acetate injected in patients with pain due to lumbar spinal stenosis or herniated disks: a prospective study.

Author: MobaleghiJafar, AllahdiniFaramarz, NasseriKarim, AhsanBehzad, ShamiShoaleh, FaiziMansour, GharibiFardin

Pain reduction

Epidural steroid injections (ESI) showed less analgesic effect and a less permanent effect in patients with lumbar spinal stenosis (LSS) compared to those with herniated disks (HD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

Nitrate patch prevents steroid-related bone necrosis.

Author: DrescherWolf, BeckmannRainer, KaschRichard, PufeMelanie, KnobeMatthias, KweiderNisreen, HassenpflugJoachim, TingartMarkus, PufeThomas, KadyrovMahmed

Prevent FHN

Nitrate patch was investigated as a preventive measure for steroid-related bone necrosis in a rabbit model.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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