Paper Details

  1. Home
  2. Paper Details

Marijuana and endothelial dysfunction: new mechanism and therapy.

Author: FengXiaojun, WengJianping, XuSuowen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
CommentA short article/note that provides an opinion/perspective/interpretation on a published paper/topic.

Overview

This study found that soy isoflavone genistein can attenuate Δ9-tetrahydrocannabinol (Δ9-THC)-induced endothelial dysfunction and atherosclerosis by directly antagonizing peripheral cannabinoid receptor 1. These findings suggest a potential therapeutic approach for ameliorating the cardiovascular side effects of cannabis.
Paper Details　
Original Abstract of the Article :
Marijuana (cannabis) can cause cardiovascular side effects, yet the mechanisms and treatments remain poorly understood. In a recent study published in Cell, Wei et al. discovered that soy isoflavone genistein attenuates Δ9-tetrahydrocannabinol (Δ9-THC, a main constituent from marijuana)-induced endo...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.molmed.2022.05.009

データ提供：米国国立医学図書館（NLM）

Cannabis and Endothelial Dysfunction: Understanding the Complexities

Cannabis, a plant containing psychoactive compounds, can have cardiovascular side effects, including endothelial dysfunction, a condition that affects the lining of blood vessels. This research explores the effects of cannabis on endothelial function and its potential therapeutic implications. It's like a journey through the intricate landscape of the cardiovascular system, seeking to understand the impact of cannabis on blood vessel health. The researchers discovered that genistein, a soy isoflavone, can attenuate the negative effects of Δ9-tetrahydrocannabinol (Δ9-THC), a main constituent of cannabis, on endothelial function, suggesting its potential as a therapeutic agent.

Genistein: A Potential Remedy for Cannabis-Induced Endothelial Dysfunction

The research highlights the potential of genistein to protect against cannabis-induced endothelial dysfunction. The authors emphasize the need for further research to evaluate the safety and efficacy of genistein in humans.

Cannabis and Cardiovascular Health: A Complex Relationship

This research emphasizes the need for ongoing research to understand the complex relationship between cannabis and cardiovascular health. It's a reminder that the desert of medical knowledge is vast and ever-evolving, requiring continuous exploration and investigation.

Dr. Camel's Conclusion

This research is like a compass guiding us through the desert of cannabis research, offering new insights into its effects on cardiovascular health. The authors have revealed a potential therapeutic agent, genistein, for mitigating the negative effects of cannabis on endothelial function, offering hope for a better understanding of this complex relationship.

Date :
  1. Date Completed 2022-08-02
  2. Date Revised 2022-09-06
Further Info :

Pubmed ID

35701315

DOI: Digital Object Identifier

10.1016/j.molmed.2022.05.009

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.