Drugs-associated with red man syndrome: An integrative approach using disproportionality analysis and Pharmip.

Author: ChandniVenkumahanti, Lakshmi PrasannaV Marise, M ShajuAina, NairGouri, PanickerNishi, SubeeshViswam

Paper Details 
Original Abstract of the Article :
Red man syndrome (RMS) is a non-IgE-mediated anaphylactoid adverse event frequently witnessed after a rapid infusion of vancomycin. This study aims to unravel drugs and associated off-label targets that induce RMS by exploiting FDA Adverse Event Reporting System (FAERS) and Pharmacovigilance/Pharmac...See full text at original site
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引用元:
https://doi.org/10.1111/jcpt.13716

データ提供:米国国立医学図書館(NLM)

Red Man Syndrome: Unveiling the Drugs and Off-Label Targets

Red man syndrome (RMS) is a serious adverse drug reaction that can occur after rapid infusion of vancomycin. This research aims to identify other drugs and associated off-label targets that may induce RMS. The study utilizes data from the FDA Adverse Event Reporting System (FAERS) and the Pharmacovigilance/Pharmacogenomics Insilico Pipeline (PHARMIP) to perform disproportionality analysis. This approach helps identify potential associations between drugs and adverse events, expanding our understanding of RMS and its potential triggers.

Red Man Syndrome: A Desert of Uncertainty

Imagine a camel wandering through a vast and unfamiliar desert, where the dangers are often hidden and unpredictable. In the realm of drug reactions, RMS is like a sandstorm, appearing suddenly and causing discomfort. This research is like a guidebook, helping us navigate this desert of uncertainty by identifying the drugs and targets that may contribute to RMS.

Expanding Our Knowledge of Drug Reactions: A Crucial Step

Understanding the causes of RMS is crucial for improving patient safety and minimizing the risks associated with drug therapy. This study is like a group of camels working together to map out the desert, uncovering new information and expanding our knowledge about RMS and its potential triggers. By identifying other drugs and off-label targets that may induce RMS, we can better manage patient care and prevent this potentially serious adverse drug event.

Dr.Camel's Conclusion

This research provides valuable insights into the potential drugs and targets associated with RMS. It's like finding a new oasis in the desert, offering a fresh perspective and a deeper understanding of this adverse drug reaction. This study underscores the importance of ongoing pharmacovigilance and the need for continuous monitoring of drug safety to ensure that patients receive safe and effective therapies.

Date :
  1. Date Completed 2022-10-06
  2. Date Revised 2022-10-06
Further Info :

Pubmed ID

35730973

DOI: Digital Object Identifier

10.1111/jcpt.13716

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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