Side Effects of vancomycin: A Synthesis of Findings from 24 Studies

  1. Home
  2. Side Effects of vancomycin
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of vancomycin: A Synthesis of Findings from 24 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of vancomycin: A Synthesis of Findings from 24 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Vancomycin is a crucial antibiotic used to treat infections caused by bacteria like MRSA (methicillin-resistant Staphylococcus aureus). While effective, vancomycin can lead to various side effects. This document examines recent research on vancomycin's side effects, their clinical significance, and future research directions.

Reasons for Side Effects

Vancomycin's side effects arise from its pharmacological action and individual patient factors. It works by hindering bacterial cell wall synthesis, but can also impact human cells, leading to adverse reactions.

Common Side Effects

Red Man Syndrome

This allergic reaction occurs due to histamine release during rapid intravenous vancomycin administration. 5 . It can manifest as rash, redness, fever, and low blood pressure. Red man syndrome can be prevented by slower infusion rates. 5 . Pre-administration of antihistamines is also beneficial. 5 .

Nephrotoxicity

Vancomycin can harm the kidneys. 23 . Accumulation in the kidneys can lead to reduced kidney function and acute kidney injury. Monitoring kidney function during vancomycin treatment is essential, and dosage adjustments may be needed. 23 .

Hearing Loss

Vancomycin can have adverse effects on the inner ear. 12 . High doses or prolonged use can cause hearing loss and tinnitus. Monitoring hearing during vancomycin treatment is important, and dosage adjustments may be necessary.

Other Side Effects

Vancomycin can cause various side effects, including rash, digestive issues (nausea, vomiting, diarrhea), and low platelet count. These side effects generally improve upon stopping vancomycin use.

Countermeasures for Side Effects

Countermeasures for Red Man Syndrome

Red man syndrome can be prevented by administering vancomycin slowly. 5 . Pre-administration of antihistamines can also help. 5 .

Countermeasures for Nephrotoxicity

Monitoring kidney function during vancomycin treatment is crucial, and dosage adjustments may be needed. 23 .

Countermeasures for Hearing Loss

Monitoring hearing during vancomycin treatment is important, and dosage adjustments may be necessary.

Countermeasures for Other Side Effects

Consult a doctor if side effects arise. Dosage adjustments or discontinuation of vancomycin may be required.

Comparison Between Studies

Commonalities Between Studies

Numerous studies confirm that vancomycin can cause various side effects. Red man syndrome, nephrotoxicity, and hearing loss are prominent side effects associated with vancomycin use.

Differences Between Studies

Individual studies show varying types, frequencies, and severities of side effects caused by vancomycin. This variation stems from differences in study populations, designs, and vancomycin administration methods and dosages.

Points to Note When Applying Research Findings to Daily Life

Vancomycin is a powerful antibiotic effective for treating infections. However, it can cause various side effects, making it essential to use it according to your doctor's instructions. When taking vancomycin, consult with your doctor about potential side effects and determine the appropriate administration method and dosage for your condition. During vancomycin treatment, carefully monitor your body, and consult your doctor immediately if you experience any abnormalities.

Limitations of Current Research

Research on vancomycin's side effects is still insufficient. Much remains unknown about long-term side effects and the mechanisms behind the diverse adverse reactions caused by vancomycin. Research on interactions between vancomycin and other medications is also lacking.

Future Research Directions

Further research is needed to gain a deeper understanding of vancomycin's side effects. Studies focused on long-term side effects and elucidating the mechanisms of various side effects are crucial. Research on drug interactions between vancomycin and other medications is also essential.

Conclusion

Vancomycin is a valuable antibiotic for treating infections, but it can lead to various side effects. When taking vancomycin, consult with your doctor about side effects, determine the appropriate administration method and dosage, and closely monitor your body. Seek immediate medical attention if you experience any abnormalities.

Literature analysis of 24 papers
Positive Content
14
Neutral Content
2
Negative Content
7
Article Type
1
0
0
3
20
4.

A Rare Case of Chronic Photophobia Associated With Oral Vancomycin Therapy: Exploring the Relationship.

Author: Moideen SheriffSerin, ChukwunyeluNonso Kingsley, EzeafulukweChinedu J, KunnelSandra S, HassanOmar A

Vancomycin is a drug that is used to treat bacterial infections. A case study reports a rare side effect of vancomycin, chronic photophobia, in a patient.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

5.

Oral antihistamines reduce the side effects from rapid vancomycin infusion.

Author: RenzC L, ThurnJ D, FinnH A, LynchJ P, MossJ

Attenuates red man syndrome
Practical
safe and inexpensive
Histamine-mediated side effects
Hypotension
Rash

Oral antihistamines were as effective as intravenous antihistamines in preventing "red man syndrome," a side effect of rapid vancomycin infusion. Treatment with oral H1 and H2 antihistamines significantly reduced the incidence and severity of rash, hypotension, and vancomycin discontinuation, compared to placebo. Oral antihistamines offer a practical, safe, and cost-effective option for preventing red man syndrome.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

6.

[A Novel Approach to Analyze the Factors Affecting Adverse Drug Reactions by Combination of Electronic Medical Record Database and Machine Learning Method].

Author: ImaiShungo

Adverse drug reactions

This review discusses the combination of big data and decision tree analyses for understanding adverse drug reactions. Decision tree analysis can identify factors affecting adverse drug reactions but requires a large number of cases. Combining big data with decision tree analysis can overcome this limitation, but the results need careful consideration when applying them to clinical practice.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

9.

[Adverse drug reactions to multiple antibiotics].

Author: ScolariMariano, TrovatoDaiana, KotLilian, ErnstGlenda

Multidrug intolerance syndrome

This case report describes a woman diagnosed with multisensitive Staphylococcus aureus endocarditis who experienced adverse reactions to five different antibiotics in two hospitalizations. This case may be an example of multidrug intolerance syndrome, an under-reported entity, or an as-yet uncharacterized condition.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.

Language : Spanish

10.

Predicting adverse drug effects: A heterogeneous graph convolution network with a multi-layer perceptron approach.

Author: ChenY-H, ShihY-T, ChienC-S, TsaiC-S

Drug side effects

This study utilized a heterogeneous graph convolution network (GCNMLP) to predict potential side effects of drugs. The model outperformed other machine learning methods in predicting known side effects and even identified new potential side effects of drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Treatment optimization by monitoring vancomycin concentration in the serum and cerebrospinal fluid in a child with cystoperitoneal shunt-related infection caused by methicillin-resistant Staphylococcus aureus: a case report and literature review.

Author: MizunoShinsuke, KoyamaJunji, KurosawaHiroshi, KasaiMasashi

Treatment of shunt infections

This study examines the challenges of treating cerebral ventricular shunt infections caused by methicillin-resistant Staphylococcus aureus (MRSA) with high minimum inhibitory concentration (MIC) values. The importance of therapeutic drug monitoring for vancomycin (VCM) and maintaining high VCM concentrations in the cerebrospinal fluid (CSF) are highlighted, with a focus on pediatric patients.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Comparison of mortality and clinical failure rates between vancomycin and teicoplanin in patients with methicillin-resistant Staphylococcus aureus pneumonia.

Author: LeeJang Ho, ChoiMyeong Geun, ParkHyung Jun, KimHo Cheol, ChoiChang-Min

Teicoplanin for MRSA pneumonia
Vancomycin for MRSA pneumonia

This study aims to compare the efficacy and safety of vancomycin and teicoplanin in treating methicillin-resistant Staphylococcus aureus pneumonia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

A Case of Oral-Vancomycin-Induced Rash in a Patient with Acute Kidney Injury.

Author: CardozoMilena, ParmarAngadbir S, Rueda PradaLibardo, ShwetaFnu

Allergic reaction
Vancomycin side effects

This case study describes a 66-year-old patient with severe Clostridioides difficile infection (CDI) and acute renal failure who developed a suspected Vancomycin-induced allergic reaction.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

15.

A Systemic Lupus Erythematosus Patient with Cutaneous <i>Mycobacterium haemophilum</i> Infection under Belimumab Treatment: A Case Report.

Author: KimJonghun, HasegawaToshio, TadaKurisu, UeharaYuki, FukuiYukiko, NakamuraAyako, TakeiSatomi, MitaraiSatoshi, AonoAkio, IkedaShigaku

Effective for SLE
Mycobacterial infection risk

Belimumab is a B cell-targeted biologic drug used to treat systemic lupus erythematosus (SLE). This case report describes a patient who developed Mycobacterium haemophilum infection after starting belimumab therapy. This suggests that belimumab may increase the risk of mycobacterial infections.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

16.

Risk Factors for Nephrotoxicity in Methicillin-Resistant Staphylococcus aureus Bacteraemia: A Post Hoc Analysis of the CAMERA2 Trial.

Author: LeggAmy, MeagherNiamh, JohnsonSandra A, RobertsMatthew A, CassAlan, ScheetzMarc H, DaviesJane, RobertsJason A, DavisJoshua S, TongSteven Y C

Nephrotoxicity

This study investigated risk factors for nephrotoxicity in Staphylococcus aureus bacteraemia in a large clinical trial. Patients receiving combination therapy (vancomycin plus an anti-staphylococcal beta-lactam) had significantly higher rates of acute kidney injury compared to those receiving vancomycin monotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

<i>Achyranthes aspera</i> Extracts as Adjuvants for the Redressal of Antibiotic Resistance.

Author: AhmadHamna, GoharUmar Farooq, MukhtarHamid, Zia-Ui-HaqMuhammad, MarcRomina Alina, IrimieMarius, MarceanuLuigi Geo, GavrisClaudia Mihaela

Antibiotic resistance reversal
Increased antibiotic efficacy

This study evaluated the ability of extracts from Achyranthes aspera seeds and leaves to reverse antibiotic resistance. The extracts increased the sensitivity of several antibiotic-resistant bacterial strains, suggesting a potential natural approach to combating antibiotic resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study.

Author: DattaRupak, HanLing, DoyleMargaret, AlloreHeather, SanftTara, QuagliarelloVincent, Juthani-MehtaManisha

Drug events

Antibiotic therapy was independently associated with adverse drug events in hospitalized older adults with advanced cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

22.

A rare case of infant eosinophilia induced by oral vancomycin: a case report and literature review.

Author: WuYali, YinWei, GuoShan, WangFang

Diarrhea
Eosinophilia
Organ damage

Oral vancomycin is typically used to treat *Clostridium difficile* infection. However, a recent case report found that oral vancomycin can cause antibiotic-associated diarrhea, specifically in a 2-month-old infant, with a significant increase in eosinophils. This highlights the potential for vancomycin to be absorbed in the gastrointestinal tract, particularly in vulnerable populations like infants and patients with underlying medical conditions.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Drugs-associated with red man syndrome: An integrative approach using disproportionality analysis and Pharmip.

Author: M ShajuAina, PanickerNishi, ChandniVenkumahanti, Lakshmi PrasannaV Marise, NairGouri, SubeeshViswam

Drug-target identification
RMS analysis
Red man syndrome
Vancomycin infusion

Red man syndrome (RMS) is a common side effect of rapid vancomycin infusions. This study uses the FDA Adverse Event Reporting System (FAERS) and Pharmacovigilance/Pharmacogenomics Insilico Pipeline (PHARMIP) to identify drugs and associated off-label targets that induce RMS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.