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Effects of therapies for Ebola virus disease: a systematic review and network meta-analysis.

Author: , FowlerRobert, GaoYa, GeLong, GuyattGordon, HaoQiukui, KojanRichard, TianJinhui, ZhaoYunli

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This systematic review and network meta-analysis evaluated the efficacy and safety of therapies for Ebola virus disease (EVD). REGN-EB3 and mAb114 were associated with a probable reduction in mortality compared to standard care. REGN-EB3 and mAb114 were also more effective at reducing mortality than ZMapp or remdesivir. These findings suggest that REGN-EB3 and mAb114 should be prioritized for EVD treatment.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Specific treatments targeting Ebola virus are crucial in managing Ebola virus disease. To support the development of clinical practice guidelines on medications for Ebola virus disease, we aimed to evaluate the efficacy and safety of therapies for patients with Ebola virus disease. METH...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441701/

データ提供：米国国立医学図書館（NLM）

Ebola Virus Disease: A Search for Effective Treatments

Ebola virus disease is a formidable foe, like a sandstorm sweeping across the desert. This study delves into the search for effective treatments, a quest as perilous as navigating a treacherous desert landscape. The authors conducted a systematic review and network meta-analysis of randomized controlled trials (RCTs), meticulously sifting through data like a seasoned archaeologist. Their findings provide valuable insights into the efficacy and safety of different therapies for Ebola virus disease.

REGN-EB3 and mAb114: Promising Hope for Ebola Virus Disease

The analysis suggests that REGN-EB3 and mAb114, two monoclonal antibody therapies, show promise in reducing mortality among Ebola virus disease patients. This is like finding a hidden oasis in the desert, offering hope for survival. These findings highlight the potential of these therapies in combating this deadly disease.

Fighting Ebola: A Collaborative Effort

The study emphasizes the importance of continued research and collaboration in the fight against Ebola virus disease. By pooling our knowledge and resources, we can develop more effective treatments and save lives. This is a global challenge that requires a united effort, like a caravan working together to overcome obstacles in the desert.

Dr. Camel's Conclusion

This research provides valuable insights into the efficacy and safety of different treatments for Ebola virus disease. It highlights the potential of REGN-EB3 and mAb114 as promising therapies. By continuing to research and collaborate, we can better equip ourselves to combat this dangerous disease and provide hope for those affected.

Date :
  1. Date Completed 2022-09-08
  2. Date Revised 2022-12-22
Further Info :

Pubmed ID

35803293

DOI: Digital Object Identifier

PMC9441701

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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