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Effect of long-term valproic acid therapy on lipid profiles in paediatric patients with epilepsy: a meta-analysis

Author: ChenFeng, DongNa, GuoHong-Li, HuYa-Hui, LuXiao-Peng, QiuJin-Chun, TianMan, XiaYing, ZengYuan-Yuan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

This meta-analysis reviewed the effects of valproic acid (VPA) therapy on lipid profiles in children with epilepsy. VPA therapy was associated with a significant reduction in total cholesterol and low-density lipoprotein cholesterol levels. No significant effects were observed on high-density lipoprotein cholesterol or triglycerides.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Despite the potential role of valproic acid (VPA) in weight gain, the effects of VPA therapy on lipid profiles remain unclear. This study aimed to review the influence of VPA therapy on serum lipid profiles in children with epilepsy. METHODS: This meta-analysis was conducted on data from...See full text at original site
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引用元：
https://doi.org/10.1684/epd.2022.1460

データ提供：米国国立医学図書館（NLM）

Valproic Acid: Navigating the Desert of Epilepsy Treatment

The desert of epilepsy treatment is often characterized by a search for effective and safe medications. This research explores the impact of valproic acid (VPA), a commonly used anti-epileptic drug, on lipid profiles in children with epilepsy. The authors conducted a meta-analysis, like a comprehensive map of multiple studies, to investigate the potential effects of VPA therapy on lipid levels in this vulnerable population. Their findings provide insights into the potential effects of VPA on lipid profiles in pediatric epilepsy patients.

A Shifting Landscape: Valproic Acid and Lipid Profiles

This meta-analysis sheds light on the potential effects of valproic acid on lipid profiles in children with epilepsy. The authors found that VPA therapy can lead to a reduction in total cholesterol and low-density lipoprotein (LDL) cholesterol levels, suggesting a potential impact on cardiovascular health. This study highlights the importance of careful monitoring of lipid profiles in children receiving VPA therapy, emphasizing the need for a personalized approach to managing this condition.

Navigating the Desert Wisely: Valproic Acid and Pediatric Epilepsy

This research underscores the importance of a balanced approach to managing pediatric epilepsy with valproic acid. The authors highlight the potential impact of VPA on lipid profiles, emphasizing the need for careful monitoring and personalized treatment strategies. This study provides valuable insights for doctors, guiding them in managing pediatric epilepsy with VPA therapy more effectively.

Dr. Camel's Conclusion

This research reminds us that the desert of epilepsy treatment is full of nuances. Valproic acid, like a valuable resource in the desert, can be both beneficial and challenging. By carefully monitoring lipid profiles and tailoring treatment approaches, we can navigate the complexities of VPA therapy, ensuring a safer and more effective journey for children with epilepsy.
Date :
  1. Date Completed 2022-07-13
  2. Date Revised 2022-10-11
Further Info :

Pubmed ID

35816100

DOI: Digital Object Identifier

10.1684/epd.2022.1460

SNS
PICO Info
in preparation
Languages

English

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