Dual-sensitive drug-loaded hydrogel system for local inhibition of post-surgical glioma recurrence.

Author: ChaiMeihong, ChenSunhui, GuGuolong, HeHuining, HeoDong Nyoung, QiuQiujun, SheDejun, WangDongdong, WangJianxin, YinBo

Paper Details 
Original Abstract of the Article :
Local treatment after resection to inhibit glioma recurrence is thought to able to meet the real medical needs. However, the only clinically approved local glioma treatment-wafer containing bis(2-chloroethyl) nitrosourea (BCNU) showed very limited effects. Herein, in order to inhibit tumor recurrenc...See full text at original site
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引用元:
https://doi.org/10.1016/j.jconrel.2022.07.011

データ提供:米国国立医学図書館(NLM)

Glioma Recurrence: Building a Desert Fortress Against Tumor Growth

Glioma, like a persistent desert sandstorm, can recur after surgical resection, presenting a significant challenge for cancer patients. This study explores a novel drug delivery system designed to inhibit glioma recurrence after surgery, providing a potential weapon in the fight against this aggressive form of brain cancer. Researchers developed a dual-sensitive hydrogel system loaded with two chemotherapy drugs, BCNU and TMZ, to provide sustained and synergistic therapeutic effects at the tumor site.

A Desert Fortress: Targeting Glioma Recurrence

Imagine a desert fortress, with multiple layers of defense to protect against invaders. This study describes a multi-layered drug delivery system that aims to prevent glioma recurrence. The researchers developed a thermosensitive hydrogel that encapsulates chemotherapy drugs within reactive oxygen species (ROS)-sensitive nanoparticles. This approach allows for targeted and controlled drug release at the tumor site, potentially inhibiting tumor growth and preventing recurrence.

Hope on the Horizon: Combating Glioma Recurrence

This research, like a beacon of hope in a desert landscape, offers a new avenue for fighting glioma recurrence. The study's findings suggest that this dual-sensitive drug delivery system could significantly enhance the effectiveness of post-surgical treatment for glioma, improving patient outcomes and potentially extending lives.

Dr.Camel's Conclusion

Glioma recurrence is a formidable opponent, but this study offers a potential solution with a novel drug delivery system. Like building a desert fortress, researchers have designed a multi-layered approach to deliver chemotherapy drugs directly to the tumor site, potentially preventing recurrence and improving patient outcomes. This research provides a glimmer of hope in the fight against this aggressive form of brain cancer.

Date :
  1. Date Completed 2022-09-20
  2. Date Revised 2022-10-19
Further Info :

Pubmed ID

35835399

DOI: Digital Object Identifier

10.1016/j.jconrel.2022.07.011

Related Literature

SNS
PICO Info
in preparation
Languages

English

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