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Systematic review and meta-analysis of augmentation and combination treatments for early-stage treatment-resistant depression.

Author: CarterBen, CleareAnthony J, EmreCansu, GnanapragasamSam, HampseyElliot, KorotkovaLora, Martín-DombrowskiJonatan, MarwoodLindsey, ScottFraser, StrawbridgeRebecca, TaylorRachael W, YoungAllan H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study aims to evaluate the effectiveness of adding additional treatments (augmentation) to standard treatments for people with depression who haven't responded well to initial treatments. The study focuses on people with early-stage treatment-resistant depression (TRD) to find ways to improve outcomes for those who don't respond to standard treatments.
Paper Details　
Original Abstract of the Article :
Major depressive disorder (MDD) is a highly burdensome health condition, for which there are numerous accepted pharmacological and psychological interventions. Adjunctive treatment (augmentation/combination) is recommended for the ~50% of MDD patients who do not adequately respond to first-line trea...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076341/

データ提供：米国国立医学図書館（NLM）

Early-Stage Treatment-Resistant Depression: A Challenging Oasis

Depression is a widespread condition that can be as vast and relentless as the desert. Many people struggle with treatment-resistant depression (TRD), a particularly challenging type of depression that doesn’t respond well to traditional therapies. Imagine yourself lost in the desert, searching for a solution, and coming across a small, hidden oasis—that’s what this research is like. It aims to find effective treatments for people with early-stage TRD, a group often overlooked.

Finding a Path Through the Desert

This systematic review and meta-analysis delves into the evidence for augmentation and combination treatments for early-stage TRD. Think of it as a map guiding researchers through the diverse landscape of treatment options. The study emphasizes that TRD is a significant concern, affecting approximately 50% of individuals who don’t fully respond to initial treatments. The researchers sought to determine the effectiveness of various adjunctive therapies.

New Hope for a Desolate Landscape

This research provides valuable insights into potential solutions for those suffering from early-stage TRD. It highlights the need for continued exploration of alternative treatment options to address the challenges of this complex condition. The study suggests that the right combination of therapies could provide a much-needed oasis for those struggling with TRD.

Dr. Camel's Conclusion

This research underscores the importance of addressing early-stage TRD and exploring innovative treatments for this challenging condition. It offers a beacon of hope for individuals seeking effective interventions. The study highlights the need for continued research and collaboration to illuminate the path towards better mental health outcomes.
Date :
  1. Date Completed 2023-04-04
  2. Date Revised 2023-06-03
Further Info :

Pubmed ID

35861202

DOI: Digital Object Identifier

PMC10076341

Related Literature

Article Analysis
・Effective treatment of depression
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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