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Use of Tox21 Screening Data to Evaluate the COVID-19 Drug Candidates for Their Potential Toxic Effects and Related Pathways.

Author: HuangRuili, SakamuruSrilatha, XiaMenghang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study summarized the toxicological profiles of small molecule drugs that are currently under clinical trials for the treatment of COVID-19. The researchers used Tox21 *in vitro* assay datasets to evaluate the potential toxicological effects of these drugs. The researchers found that many of these drugs have potential toxicities, highlighting the importance of further safety studies.
Paper Details　
Original Abstract of the Article :
Currently, various potential therapeutic agents for coronavirus disease-2019 (COVID-19), a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are being investigated worldwide mainly through the drug repurposing approach. Several anti-viral, anti-bacterial, an...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333127/

データ提供：米国国立医学図書館（NLM）

Assessing COVID-19 Drug Candidates for Potential Toxicity

This study explores the potential toxic effects of various drug candidates being investigated for the treatment of COVID-19. The researchers utilized a comprehensive dataset of in vitro assay results from the Tox21 program, which screened thousands of compounds, including approved drugs and environmental chemicals, against multiple cellular targets and pathways. The study analyzed the toxicological profiles of drug candidates currently under clinical trials for COVID-19, identifying potential toxic effects and associated pathways. The study highlights the importance of early toxicity assessment in drug development, particularly for repurposed drugs, which may have unanticipated side effects.

Toxicity Screening for COVID-19 Treatments

This study underscores the importance of comprehensive toxicity screening during the development of new drugs for COVID-19. The findings highlight the potential for repurposed drugs to have unanticipated side effects and emphasize the need for careful evaluation of drug candidates before clinical use.

Navigating Pandemics: A Camel's Perspective on Safety

As a camel, I've learned to be cautious in harsh environments. The COVID-19 pandemic, much like a desert storm, has brought its own challenges. This study highlights the importance of careful evaluation and safety assessment when seeking new treatments, ensuring that potential benefits outweigh any risks.

Dr.Camel's Conclusion

This study underscores the importance of early toxicity assessment in the development of new drugs for COVID-19, particularly for repurposed drugs. The findings highlight the potential for unanticipated side effects and emphasize the need for careful evaluation of drug candidates before clinical use.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-08-02
Further Info :

Pubmed ID

35910344

DOI: Digital Object Identifier

PMC9333127

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Languages

English

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