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Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain.
Author: AlbacarysLauren K, BettegowdaChetan, DhindsaRyan S, DongXinzhong, GreenDustin P, HuangJudy, KothariRuchita, KwatraShawn G, LiewJason, LimMichael, LucianoMark, MoghekarAbhay, Pardo-VillamizarCarlos A, PaulBindu D, SabbaghMark F, SemenzaEvan R, ShinJoseph Y, SnowmanAdele M, SnyderSolomon H, VasavdaChirag, XuRisheng, YangWuyang
Original Abstract of the Article :
Trigeminal neuralgia, historically dubbed the "suicide disease," is an exceedingly painful neurologic condition characterized by sudden episodes of intense facial pain. Unfortunately, the only U.S. Food and Drug Administration (FDA)-approved medication for trigeminal neuralgia carries substantial si...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348805/
データ提供：米国国立医学図書館（NLM）
NRF2 Transcriptional Network: A Potential Therapeutic Target for Trigeminal Neuropathic Pain
Trigeminal neuralgia, a debilitating neurological condition characterized by excruciating facial pain, can be a devastating experience. This research, like a desert oasis offering relief from the scorching heat, explores a potential therapeutic target for trigeminal neuropathic pain - the NRF2 transcriptional network. The authors delve into the underlying mechanisms of this condition, uncovering the role of oxidative stress and the potential for NRF2 modulation to alleviate pain.
Oxidative Stress and Trigeminal Neuropathic Pain
The study found that cerebrospinal fluid from patients with trigeminal neuralgia exhibited elevated levels of reactive oxygen species, suggesting a role for oxidative stress in the pathogenesis of this condition. The authors further discovered that stimulating the NRF2 antioxidant network could effectively reduce pain, potentially by reversing the underlying oxidative stress. It is like a camel adapting to the harsh desert environment, finding ways to combat dehydration and protect itself from harmful elements.
New Hope for Trigeminal Neuralgia Treatment
The research provides promising insights into the potential for NRF2-based therapies for trigeminal neuropathic pain. This could offer a novel and potentially safer alternative to existing treatments, providing relief for individuals suffering from this debilitating condition. It is like a desert oasis offering a sanctuary from the heat and a chance to replenish and heal.
Dr.Camel's Conclusion
This research offers a ray of hope for individuals struggling with trigeminal neuropathic pain. By exploring the role of oxidative stress and the potential for NRF2 modulation, the study provides valuable insights into the potential for novel and effective treatment strategies. It is like a camel discovering a hidden spring in the desert, offering a source of healing and rejuvenation for those seeking relief from pain and suffering.
Date :
- Date Completed n.d.
- Date Revised 2023-03-06
Further Info :
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