Denosumab treatment is associated with decreased cortical porosity and increased bone density and strength at the proximal humerus of ovariectomized cynomolgus monkeys.

Author: BoydSteven K, EdwardsW Brent, HaiderIfaz T, KostenuikPaul J, PageRebecca, SawatskyAndrew, ZhuYing

Paper Details 
Original Abstract of the Article :
Upper extremity fractures, including those at the humerus, are common among women with postmenopausal osteoporosis. Denosumab was shown to reduce humeral fractures in this population; however, no clinical or preclinical studies have quantified the effects of denosumab on humerus bone mineral density...See full text at original site
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引用元:
https://doi.org/10.1016/j.bone.2022.116517

データ提供:米国国立医学図書館(NLM)

Denosumab: A New Oasis in the Desert of Osteoporosis

In the field of [bone health], [osteoporosis] poses a significant challenge, particularly for postmenopausal women. This study investigates the effects of denosumab, a medication used to treat osteoporosis, on bone density and strength in ovariectomized cynomolgus monkeys. It's like exploring a new oasis in the desert of bone health research, seeking ways to strengthen and protect bone structure. The researchers used micro-computed tomography (μCT) and computed tomography (CT) to quantify the impact of denosumab on bone morphology and strength.

Denosumab: A Promising Path to Stronger Bones

The study found that denosumab significantly decreased cortical porosity and increased bone density and strength at the proximal humerus in ovariectomized monkeys. This is a promising discovery, like finding a hidden spring that nourishes and strengthens the desert landscape. The findings suggest that denosumab could potentially reduce the risk of humeral fractures in postmenopausal women, offering a potential path to improved bone health.

A New Approach to Osteoporosis Prevention

This study highlights the potential of denosumab to improve bone density and strength, offering a new approach to osteoporosis prevention. It's like discovering a new method for irrigating the desert, ensuring a more robust and resilient environment. This research underscores the importance of continuing to explore new and effective treatments for osteoporosis, providing hope for those seeking to maintain strong bones and prevent fractures.

Dr. Camel's Conclusion

This study provides valuable insights into the potential benefits of denosumab for improving bone density and strength in postmenopausal women. It highlights the importance of ongoing research and development in the field of osteoporosis treatment, paving the way for a future where stronger bones and a reduced risk of fractures are within reach.

Date :
  1. Date Completed 2022-09-26
  2. Date Revised 2022-10-14
Further Info :

Pubmed ID

35961611

DOI: Digital Object Identifier

10.1016/j.bone.2022.116517

Related Literature

SNS
PICO Info
in preparation
Languages

English

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