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Mesalamine and cholestyramine for immune checkpoint inhibitor-mediated diarrhea and colitis.

Author: AlasadiMazen, AltanMelmet, HollanderBarbara, JacobJake S, KhuranaShruti, ThomasAnusha S, VaratharajaluKrishnavathana, WangJianbo, WangYinghong, ZhaoDan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluates the role of non-immunosuppressive agents, mesalamine and cholestyramine, in managing diarrhea and colitis associated with immune checkpoint inhibitors (ICI), offering alternative approaches to steroid and biologic therapies.
Paper Details　
Original Abstract of the Article :
Immune checkpoint inhibitors (ICI) are effective against various malignancies. However, adverse events including diarrhea and colitis can lead to significant morbidity and mortality. Recommendations for the management of ICI mediated diarrhea and colitis include steroids and biologics. Given their a...See full text at original site
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引用元：
https://doi.org/10.1007/s00432-022-04116-9

データ提供：米国国立医学図書館（NLM）

Mesalamine and Cholestyramine: Potential Allies in the Fight Against ICI-Mediated Diarrhea and Colitis

The use of immune checkpoint inhibitors (ICIs) in cancer treatment has revolutionized oncology, but these powerful drugs can come with significant side effects, including diarrhea and colitis. This study delves into the potential benefits of mesalamine and cholestyramine, two non-immunosuppressive agents, in managing these debilitating side effects. The authors examine the use of these agents as alternatives to traditional treatments like steroids and biologics, which often carry their own risks.

Navigating the Side Effects of ICIs: Exploring New Therapeutic Avenues

The study explores the potential role of mesalamine and cholestyramine in managing ICI-mediated diarrhea and colitis, suggesting that these agents may offer a safer and more effective alternative to traditional immunosuppressive therapies. This research, like a desert explorer seeking a hidden oasis, highlights the need for new and innovative approaches to managing the side effects of cancer treatments.

Managing Cancer Treatment Side Effects: Finding Balance and Relief

This study underscores the importance of managing the side effects of cancer treatment, ensuring that patients can experience the benefits of ICIs without undue suffering. The authors' exploration of mesalamine and cholestyramine as potential therapeutic options offers a beacon of hope for patients experiencing ICI-mediated diarrhea and colitis.

Dr.Camel's Conclusion

This study offers a promising exploration of mesalamine and cholestyramine as potential therapeutic options for managing ICI-mediated diarrhea and colitis. The authors' investigation of non-immunosuppressive agents highlights the importance of finding safe and effective alternatives to traditional treatments. This research encourages further investigation into these agents and other innovative approaches to managing the side effects of cancer therapies, ensuring that patients can experience the benefits of these life-saving treatments while minimizing the burden of debilitating side effects.

Date :
  1. Date Completed 2023-07-05
  2. Date Revised 2023-07-05
Further Info :

Pubmed ID

35972690

DOI: Digital Object Identifier

10.1007/s00432-022-04116-9

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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