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Sodium channel-directed alkaloids synergize the mosquitocidal and neurophysiological effects of natural pyrethrins.

Author: BloomquistJeffrey R, NorrisEdmund J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Aconitine and veratrine, two sodium channel activators, showed potential as insecticides and synergists for natural pyrethrins (NP) against Aedes aegypti. Aconitine was more toxic than veratrine, but only aconitine exhibited significant resistance in the pyrethroid-resistant Puerto Rico strain. When combined with piperonyl butoxide (PBO), both aconitine and veratrine synergized NP, leading to increased toxicity against the Orlando strain. Aconitine + PBO synergized NP 21.8-fold, while veratrine + PBO synergized NP 5.3-fold. These findings suggest that sodium channel activators could be used as insecticides and synergists for pyrethroids, potentially extending the effectiveness of these essential public health vector control agents.
Paper Details　
Original Abstract of the Article :
We explored the potential of two sodium channel activators, veratrine and aconitine, as both insecticides and synergists of natural pyrethrins (NP) on Aedes aegypti adults and larvae. Aconitine was more toxic than veratrine, with an LD<sub>50</sub> of 157&#160;ng/mg compared to 376&#160;ng/mg, on th...See full text at original site
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引用元：
https://doi.org/10.1016/j.pestbp.2022.105171

データ提供：米国国立医学図書館（NLM）

Synergistic Strategies: Combating Mosquitoes with a Double-Edged Sword

In the ongoing battle against mosquito-borne diseases, researchers are constantly searching for new and effective methods of control. This research explores the potential of combining natural pyrethrins, a widely used insecticide, with sodium channel activators, like veratrine and aconitine, to enhance their mosquitocidal effects. The authors investigate the synergistic action of these compounds, examining their impact on both mosquito adults and larvae.

A New Alliance: Sodium Channel Activators as Insecticide Synergists

This research unveils a promising strategy for amplifying the effectiveness of pyrethrins against mosquitoes. The authors demonstrate that sodium channel activators, like veratrine and aconitine, can significantly synergize the mosquitocidal effects of pyrethrins. This synergistic action offers a potential solution to the growing problem of insecticide resistance, enhancing the efficacy of existing control measures. The authors also show that these compounds can act as insecticides in their own right, providing a dual-pronged approach to mosquito control.

A New Era of Mosquito Control: Embracing Synergistic Strategies

This research suggests a shift towards a more comprehensive approach to mosquito control, incorporating synergistic strategies to combat insecticide resistance. The findings highlight the potential of combining natural pyrethrins with sodium channel activators to enhance their efficacy. This research could contribute to a more sustainable and effective approach to combating mosquito-borne diseases, potentially saving lives and improving public health.

Dr.Camel's Conclusion

This research offers a promising avenue for enhancing the effectiveness of mosquito control strategies. The authors' findings suggest that sodium channel activators can significantly synergize the mosquitocidal effects of pyrethrins, potentially providing a solution to the growing problem of insecticide resistance. This research highlights the importance of exploring innovative approaches and embracing synergistic strategies to combat mosquito-borne diseases.
Date :
  1. Date Completed 2022-08-18
  2. Date Revised 2022-09-24
Further Info :

Pubmed ID

35973763

DOI: Digital Object Identifier

10.1016/j.pestbp.2022.105171

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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