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In Vitro Effects of Acitretin on Human Neuronal SH-SY5Y Cells.

Author: CaiAojie, GaoKai, JiangYuwu, LiXiao, LinZehong, LiuNana, WangJingmin, WuYe

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Acitretin, a psoriasis treatment, was investigated for its role in neuronal development. It promoted differentiation of SH-SY5Y cells into neuronal cells and upregulated expression of neuronal markers. Acitretin-treated neurons generated electrical spikes, suggesting its potential for treating brain tumors and neurodevelopmental and neurodegenerative diseases.
Paper Details　
Original Abstract of the Article :
Acitretin is an oral drug approved by the Food and Drug Administration that is commonly used to treat psoriasis. In recent years, acitretin has been identified as a candidate drug for the treatment of Alzheimer's disease, but its role in neuronal development is still unclear. In this study, the huma...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822877/

データ提供：米国国立医学図書館（NLM）

Acitretin: A Potential New Tool for Neuronal Development

Acitretin, a drug currently used to treat psoriasis, has shown promise as a potential treatment for Alzheimer's disease. This research investigates the effects of acitretin on human neuronal SH-SY5Y cells, providing insights into its potential role in neuronal development.

Promoting Neuronal Growth: A New Perspective on Acitretin

The researchers found that acitretin effectively promoted the differentiation of SH-SY5Y cells into neuronal cells, suggesting its potential to support healthy brain development. They also identified specific genes and pathways involved in this process, paving the way for further investigation into the mechanisms underlying acitretin's effects. This research opens new avenues for exploring the therapeutic potential of acitretin in various neurological conditions.

A Promising Future for Neurological Therapies

This research provides a valuable stepping stone for developing new therapies for neurological disorders. The findings suggest that acitretin, with its ability to promote neuronal growth and differentiation, could potentially be a valuable tool for treating a range of neurological conditions, from brain tumors to neurodevelopmental and neurodegenerative disorders.

Dr. Camel's Conclusion

Acitretin's potential in neuronal development is like a hidden oasis in the vast desert of neurological disorders. Its ability to promote neuronal growth and differentiation offers hope for finding new treatments for a wide range of neurological conditions. This research is a reminder that the desert of knowledge is full of hidden treasures waiting to be discovered.
Date :
  1. Date Completed 2023-01-10
  2. Date Revised 2023-01-11
Further Info :

Pubmed ID

35987975

DOI: Digital Object Identifier

PMC9822877

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・Effects of acitretin
SNS
PICO Info
in preparation
Languages

English

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