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Transcutaneous cervical vagus nerve stimulation reduces behavioral and physiological manifestations of withdrawal in patients with opioid use disorder: A double-blind, randomized, sham-controlled pilot study.

Author: AlaviParvaneh, BackSudie E, BremnerJ Douglas, DriggersEmily G, GaziAsim H, GuptaRahul, HarrisonAnna B, InanOmer T, LambertTamara P, MurrahNancy, ObideenMalik, OrtegaRebeca Alvarado, ShahAmit J, ShallenbergerLucy, TangYi-Lang, VaccarinoViola, WaltonKevin M, WashingtonBrianna P, WelshJustine W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study found that transcutaneous cervical vagus nerve stimulation (tcVNS) can reduce both behavioral and physiological manifestations of opioid withdrawal. Compared to sham stimulation, tcVNS was associated with statistically significant reductions in subjective opioid withdrawal, pain, and distress. The results suggest that tcVNS could be a useful non-pharmacological approach for adjunctive treatment of opioid use disorder (OUD).
Paper Details　
Original Abstract of the Article :
BACKGROUND: Opioid Use Disorder (OUD) is a serious public health problem, and the behavioral and physiological effects of opioid withdrawal can be a major impediment to recovery. Medication for OUD is currently the mainstay of treatment; however, it has limitations and alternative approaches are nee...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/36041704

データ提供：米国国立医学図書館（NLM）

Transcutaneous Vagus Nerve Stimulation for Opioid Withdrawal

Opioid use disorder (OUD) is a complex and challenging condition, much like traversing a vast and unforgiving desert. This study investigated the potential therapeutic benefits of transcutaneous cervical vagus nerve stimulation (tcVNS) for reducing the behavioral and physiological manifestations of opioid withdrawal. The researchers explored the feasibility of using tcVNS as a non-pharmacological approach to alleviate withdrawal symptoms and support recovery.

A New Approach for Opioid Withdrawal

The study found that tcVNS, compared to sham stimulation, resulted in significant reductions in subjective opioid withdrawal, pain, and distress. These findings suggest that tcVNS may offer a promising non-pharmacological alternative or adjunct to traditional treatment options for opioid withdrawal, offering a glimmer of hope in the arid landscape of addiction treatment.

Exploring the Potential of tcVNS

This research, like a well-placed oasis in a vast desert, provides a promising avenue for exploring the therapeutic potential of tcVNS for opioid withdrawal. The study's findings encourage further investigation into the efficacy and safety of tcVNS as a potential treatment option for OUD, paving the way for novel and innovative approaches to addiction recovery.

Dr.Camel's Conclusion

This study, like a camel carrying vital supplies across the desert, offers a promising new approach for addressing the challenges of opioid withdrawal. The findings suggest that tcVNS may offer a non-pharmacological alternative or adjunct to traditional treatment options, providing a valuable tool for supporting recovery and improving the lives of individuals with OUD.

Date :
  1. Date Completed 2022-10-18
  2. Date Revised 2023-04-13
Further Info :

Pubmed ID

36041704

DOI: Digital Object Identifier

NIHMS1834596

Related Literature

Article Analysis
・Effective treatment of opioid use
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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