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Use of GAL4 factor-based yeast assay to quantify the effects of xenobiotics on RXR homodimer and RXR/PPAR heterodimer in scallop Chlamys farreri.
Author: MiaoJingjing, PanLuqing, WangQiaoqiao, WuManni, ZhaoAnran
Original Abstract of the Article :
Retinoid X receptor (RXR) and peroxisome proliferators-activated receptors (PPAR) have been shown as important targets of endocrine disrupting effects caused by organotin compounds (OTCs). In vitro methods for non-model species are instrumental in revealing not only mechanism of toxicity but also ba...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.scitotenv.2022.158526
データ提供:米国国立医学図書館(NLM)
Investigating the Impact of Xenobiotics on Scallop RXR and PPAR
In the vast and complex world of environmental science, researchers are constantly seeking to understand the intricate interactions between organisms and their surroundings. This study, like a meticulous explorer charting a new territory, focused on the effects of xenobiotics - foreign compounds - on the retinoid X receptor (RXR) and peroxisome proliferator-activated receptors (PPAR) in scallops. These receptors play a vital role in regulating various biological processes within these marine creatures, much like a wise elder guiding a nomadic tribe through the desert. The researchers developed a novel GAL4 factor-based yeast assay, a powerful tool for studying gene expression, to analyze the transcriptional activity of RXR and PPAR in scallops. Their findings revealed that several organotin compounds, like tiny grains of sand scattered across a vast desert, significantly disrupt the function of RXR and PPAR. This study underscores the need for environmental monitoring and regulation of such compounds to protect marine ecosystems.
The Power of Yeast Assays
This study demonstrates the potential of GAL4 factor-based yeast assays for studying the effects of xenobiotics on various organisms. These assays, like a highly efficient oasis-building technology, offer a cost-effective and sensitive method for analyzing gene expression and identifying potential environmental threats.
Protecting Our Oceans
The findings highlight the importance of protecting marine ecosystems from the detrimental effects of xenobiotics, particularly organotin compounds. This study, like a warning sign in the desert, reminds us of the need for sustainable practices and responsible waste management to safeguard the health and wellbeing of our oceans.
Dr.Camel's Conclusion
This study takes us on a fascinating journey into the intricate world of marine biology. By employing a sophisticated yeast assay, the researchers have uncovered the potential dangers of xenobiotics on scallop health. Their findings emphasize the importance of continuous research and vigilance to protect our oceans from these harmful compounds.
Date :
- Date Completed 2022-10-21
- Date Revised 2022-10-21
Further Info :
Related Literature
English
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