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The Combined Escherichia coli Nissle 1917 and Tryptophan Treatment Modulates Immune and Metabolome Responses to Human Rotavirus Infection in a Human Infant Fecal Microbiota-Transplanted Malnourished Gnotobiotic Pig Model.

Author: AmimoJoshua O, ChepngenoJuliet, DeblaisLoic, MichaelHusheem, RajashekaraGireesh, SaifLinda J, SrivastavaVishal, VlasovaAnastasia N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study investigated the impact of Escherichia coli Nissle 1917 (EcN) and tryptophan (TRP) supplementation on human rotavirus (HRV) infection in malnourished piglets. EcN + TRP combination resulted in a more balanced immune response and increased protection against HRV infection and diarrhea. The study identified specific metabolites linked to this protective effect.
Paper Details　
Original Abstract of the Article :
Human rotavirus (HRV) is a major cause of childhood diarrhea in developing countries where widespread malnutrition contributes to the decreased oral vaccine efficacy and increased prevalence of other enteric infections, which are major concerns for global health. Neonatal gnotobiotic (Gn) piglets cl...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599269/

データ提供：米国国立医学図書館（NLM）

Combating Rotavirus: A Tale of Two Supplements in a Pig Model

The challenge of rotavirus infection, especially in malnourished children, is like a relentless desert wind that can be difficult to withstand. This study investigates a novel approach to fight this viral foe using a model system. Researchers used malnourished gnotobiotic piglets, which are akin to human infants, to study the effects of combining Escherichia coli Nissle 1917 (EcN) and tryptophan (TRP) on rotavirus infection.

EcN + TRP Combined: A Promising Strategy for Rotavirus

The results of this study are promising. EcN + TRP combined demonstrated a synergistic effect, resulting in a greater and more balanced immune response. This combination led to greater protection against rotavirus infection and reduced diarrheal severity in the malnourished piglets. The study also identified several metabolites that may contribute to the protective effects of EcN + TRP.

Implications for Human Health and Nutrition

This research offers hope for improving the health of malnourished children who are vulnerable to rotavirus infection. The findings suggest that combining EcN and TRP could be a promising strategy for reducing diarrhea and boosting the immune system. Further research is needed to confirm these findings in human populations and to explore the potential of this approach for other enteric infections.

Dr. Camel's Conclusion

This research is a testament to the ingenuity of scientists seeking to combat the challenges of infectious diseases. By combining EcN and TRP, researchers have discovered a promising new strategy for fighting rotavirus infections in malnourished children. This research is a valuable step forward in the fight against this debilitating illness, and it offers hope for a healthier future for vulnerable populations.

Date :
  1. Date Completed 2023-03-30
  2. Date Revised 2023-03-30
Further Info :

Pubmed ID

36073800

DOI: Digital Object Identifier

PMC9599269

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in preparation
Languages

English

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