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Effects of estradiol- and ethinylestradiol-based contraceptives on adrenal steroids: A randomized trial.

Author: ArffmanRiikka K, HaverinenAnnina, HeikinheimoOskari, HustadSteinar, KangasniemiMarika H, LuiroKaisu, PiltonenTerhi T, TapanainenJuha S

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the effects of two types of combined oral contraceptives (COCs) containing either estradiol valerate (EV) or ethinylestradiol (EE) on cortisol and other adrenal steroid hormones. The study found that COCs containing EE affected adrenal function by altering steroid and corticosteroid-binding globulin (CBG) synthesis. However, the effects of COCs containing natural estrogens, such as EV, on adrenal function remain unclear.
Paper Details　
Original Abstract of the Article :
Ethinylestradiol (EE)-based combined oral contraceptives (COC) affect adrenal function by altering steroid and corticosteroid-binding globulin (CBG) synthesis that may contribute to adverse effects related to these drugs. The effects of COCs containing natural estrogens remain unclear. We compared t...See full text at original site
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引用元：
https://doi.org/10.1016/j.contraception.2022.08.009

データ提供：米国国立医学図書館（NLM）

Contraceptive Hormones and Adrenal Function: A Closer Look

This study examines the effects of different types of contraceptive hormones, specifically estradiol valerate (EV) and ethinylestradiol (EE), on adrenal steroid production. The authors conducted a randomized trial comparing the effects of COCs containing EV and EE on cortisol and other adrenal steroid hormones in women. The study found that both types of COCs affected adrenal function, but the effects were different, suggesting that the choice of contraceptive hormones may have implications for adrenal health.

A Hormonal Crossroads: Exploring Contraceptive Effects on Adrenal Function

The study's findings are like a camel caravan encountering a crossroads in the desert, where different paths lead to different destinations. The researchers compared the effects of different contraceptive hormones, carefully observing their impact on adrenal function. The results highlight the importance of considering the potential effects of contraceptive hormones on adrenal health, emphasizing the need for individualized treatment approaches and careful monitoring.

Understanding the Impact: Contraceptive Choices and Adrenal Health

This research underscores the importance of understanding the potential effects of contraceptive hormones on adrenal function. Just as a camel caravan needs to navigate a complex desert landscape, healthcare providers need to be aware of the potential impact of contraceptive choices on adrenal health. The study's findings provide valuable information for making informed decisions about contraceptive options, balancing the benefits with the potential risks to adrenal health.

Dr. Camel's Conclusion

This study sheds light on the complex interplay between contraceptive hormones and adrenal function, suggesting that the choice of contraceptives may have implications for adrenal health. It's like a camel caravan navigating a delicate balance between different forces in the desert, ensuring a safe and successful journey.

Date :
  1. Date Completed 2022-12-23
  2. Date Revised 2023-01-29
Further Info :

Pubmed ID

36084710

DOI: Digital Object Identifier

10.1016/j.contraception.2022.08.009

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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