Paper Details

  1. Home
  2. Paper Details

Secondary bile acids mediate high-fat diet-induced upregulation of R-spondin 3 and intestinal epithelial proliferation.

Author: GillillandMerritt, LeeAllen A, LiJi-Yao, OwyangChung, WuXiaoyin, ZhouShi-Yi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

A high-fat diet (HFD) contributes to the increased incidence of colorectal cancer. This study shows that HFD upregulates R-spondin 3 (Rspo3) expression in the colon, mediated by secondary bile acids produced by gut microbiota. Rspo3 promotes intestinal proliferation and may contribute to colorectal cancer development.
Paper Details　
Original Abstract of the Article :
A high-fat diet (HFD) contributes to the increased incidence of colorectal cancer, but the mechanisms are unclear. We found that R-spondin 3 (Rspo3), a ligand for leucine-rich, repeat-containing GPCR 4 and 5 (LGR4 and LGR5), was the main subtype of R-spondins and was produced by myofibroblasts benea...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675439/

データ提供：米国国立医学図書館（NLM）

The Intriguing Connection Between Diet, Bile Acids, and Intestinal Proliferation

The world of gut health is like a vast desert, with complex interactions between our diet, gut microbiota, and overall well-being. This study delves into the intriguing relationship between a high-fat diet (HFD), bile acids, and intestinal epithelial proliferation. The researchers explored the role of secondary bile acids, produced by the gut microbiota, in mediating the effects of HFD on intestinal proliferation. They found that secondary bile acids, particularly deoxycholic acid (DCA), upregulated the expression of Rspo3, a key molecule involved in intestinal cell growth. These findings shed light on the potential role of diet and the gut microbiome in influencing intestinal health and potentially contributing to colorectal cancer development.

Secondary Bile Acids: A Key Player in HFD-Induced Intestinal Proliferation

The study revealed that secondary bile acids, particularly DCA, play a crucial role in mediating the effects of HFD on intestinal proliferation. DCA, produced by the gut microbiota, increased Rspo3 expression, leading to increased intestinal epithelial cell growth. This finding provides valuable insights into the intricate interplay between diet, gut microbiota, and intestinal health.

Navigating the Desert of Diet and Gut Health

This study underscores the importance of maintaining a balanced diet and a healthy gut microbiome. Understanding the role of secondary bile acids in HFD-induced intestinal proliferation provides valuable insights for promoting intestinal health and potentially preventing colorectal cancer development.

Dr.Camel's Conclusion

This research unveils a hidden oasis in the desert of gut health. Secondary bile acids play a crucial role in the relationship between a high-fat diet and intestinal proliferation. This discovery highlights the importance of a healthy diet and a balanced gut microbiome for maintaining intestinal health.

Date :
  1. Date Completed 2022-10-11
  2. Date Revised 2023-05-31
Further Info :

Pubmed ID

36099053

DOI: Digital Object Identifier

PMC9675439

Related Literature

Article Analysis
・Effects of cholestyramine resin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.