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Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor.

Author: AlmoSteven C, CelikgilAlev, DanelonVictor, GarforthScott J, Garrett-ThomsonSarah C, HempsteadBarbara L, HerreraNatalia G, LaerkeMichelle K, LeeFrancis S, MoranoNicholas C, OlsonSteven M, PatelUttsav, SchreinerRyan, SmithCarla, SmithRoshelle S

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

B7-1, a human immunomodulatory ligand, interacts with the p75 neurotrophin receptor (p75NTR). This interaction alters dendritic morphology in cultured hippocampal neurons and affects synaptic function. The findings suggest a potential therapeutic opportunity for neuroinflammatory diseases.
Paper Details　
Original Abstract of the Article :
Cell surface receptors, ligands, and adhesion molecules underlie development, circuit formation, and synaptic function of the central nervous system and represent important therapeutic targets for many neuropathologies. The functional contributions of interactions between cell surface proteins of ne...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663165/

データ提供：米国国立医学図書館（NLM）

The Role of B7-1 in Synaptic Remodeling

The field of neuroscience is constantly striving to understand the intricate mechanisms underlying brain development and function. This research investigates the role of the human immunomodulatory ligand B7-1 (hB7-1) in synaptic remodeling. The researchers used an unbiased protein-protein interaction screen to identify the interaction between hB7-1 and the p75 neurotrophin receptor (p75NTR). They discovered that this interaction, which is unique to humans and other primates, plays a role in dendritic morphology and synaptic plasticity. The study's findings suggest that hB7-1 could be a potential therapeutic target for neuroinflammatory diseases.

Unveiling a Novel Pathway in Synaptic Remodeling

This research sheds light on a novel pathway involved in synaptic remodeling. The researchers' discovery of the interaction between hB7-1 and p75NTR, which is unique to primates, provides valuable insights into the complex mechanisms underlying brain development and function. This finding has significant implications for understanding the role of immune system components in brain function and disease.

Potential Therapeutic Applications

The study's findings suggest that hB7-1 could be a potential therapeutic target for neuroinflammatory diseases. The researchers' observations regarding the effects of hB7-1 on dendritic morphology and synaptic plasticity suggest that modulating this interaction could be a promising strategy for treating neurodegenerative diseases and other neurological disorders.

Dr.Camel's Conclusion

This research is like a desert oasis, revealing a hidden pathway in the vast landscape of the brain. The researchers, like camels navigating a desert, have unearthed a novel interaction between B7-1 and p75NTR, which could be a key to understanding and treating neuroinflammatory diseases. This discovery holds promise for developing new therapies to improve brain function and combat neurological disorders.

Date :
  1. Date Completed 2022-11-21
  2. Date Revised 2022-11-25
Further Info :

Pubmed ID

36107635

DOI: Digital Object Identifier

PMC9663165

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