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The Influence of Lipid Matrix Composition on the Microenvironment of Levofloxacin in Liposomal Forms.

Author: KolmogorovI M, KudryashovaE V, Le-DeygenI M, SafronovaA S, SkuredinaA A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the interaction of the antibacterial drug levofloxacin with lipid bilayers, finding that levofloxacin interacts with the phosphate group of anionic lipids, displacing water and not penetrating into the hydrophobic core of the bilayer. The study used a combination of spectral methods to characterize the microenvironment of levofloxacin in liposomes, providing insights into the drug's interactions with biomembranes.
Paper Details　
Original Abstract of the Article :
We have studied the interaction of the antibacterial drug levofloxacin with lipid bilayers of various compositions: 100% DPPC and with the addition of 20% cardiolipin. For DPPC liposomes, levofloxacin was found to penetrate into the subpolar region at the lipid-water interface. The role of the anion...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467668/

データ提供：米国国立医学図書館（NLM）

Levofloxacin in Liposomes: A Journey Through the Desert of Drug Delivery

Drug delivery, like a camel caravan crossing a desert, faces many challenges. This research explores the interaction of levofloxacin, an antibacterial drug, with different lipid bilayers in liposomal formulations, which are like mini-vehicles transporting the drug across the desert of the body. The researchers employed a combination of spectroscopic techniques to understand how the drug interacts with the lipid bilayers, much like observing the behavior of camels in different terrains to understand their adaptations.

Levofloxacin and Lipid Bilayers: A Delicate Dance

The study reveals that levofloxacin interacts differently with different lipid bilayers, highlighting the importance of considering the composition of the carrier system. This is like discovering that different types of camels are better suited for different terrains. The researchers found that levofloxacin penetrates into the subpolar region of 100% DPPC liposomes, while it interacts with the phosphate group of liposomes containing cardiolipin, a type of lipid found in cell membranes. This information is like knowing that camels with longer legs are better suited for sandy terrains, while camels with shorter legs are better suited for rocky terrains.

Optimizing Drug Delivery: A Desert Oasis of Innovation

This research highlights the importance of understanding the interaction between drugs and their carriers to optimize drug delivery and minimize side effects. By carefully choosing the composition of liposomal formulations, researchers can create more effective drug delivery systems, similar to choosing the right camels for the right journey across the desert.

Dr.Camel's Conclusion

This research is a fascinating journey through the desert of drug delivery. By studying the interaction of levofloxacin with different lipid bilayers, researchers can create more effective and targeted drug delivery systems, potentially leading to improved therapies for a variety of diseases.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-09-20
Further Info :

Pubmed ID

36119964

DOI: Digital Object Identifier

PMC9467668

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SNS
PICO Info
in preparation
Languages

English

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