mTORi-based immunosuppression reduces HCC recurrence at the expense of increased adverse side effects: A systematic review and meta-analysis.

Author: DuanBinwei, LiGuangming, ZhangGongming

Paper Details 
Original Abstract of the Article :
Sirolimus and everolimus are mammalian target of rapamycin inhibitors (mTORi) that can reduce relapse rates following liver transplantation (LT) for hepatocellular carcinoma (HCC). Herein, we performed a systematic review and meta-analysis to investigate the efficacy of mTORi and calcineurin inhibit...See full text at original site
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引用元:
https://doi.org/10.1111/ctr.14823

データ提供:米国国立医学図書館(NLM)

mTORi: A Double-Edged Sword in HCC Treatment

Hepatocellular carcinoma (HCC), a type of liver cancer, is a serious health concern. This study investigated the use of mTOR inhibitors (mTORi) in reducing HCC recurrence after liver transplantation. While mTORi were effective in reducing recurrence rates and improving overall survival, they also led to an increase in adverse side effects. This research provides valuable insights into the potential benefits and risks of this treatment approach.

Balancing Benefits and Risks: A Delicate Dance

This study highlights the delicate balance between benefits and risks in medical treatment. mTORi offer promise in reducing HCC recurrence, but they also come with potential side effects. Finding the right balance for each individual patient requires careful consideration and a personalized approach. It's like navigating a desert landscape where beautiful oases may be hidden by dangerous sandstorms.

Informed Decision-Making: A Crucial Step

This study underscores the importance of informed decision-making in medical treatment. Patients and their doctors need to carefully weigh the potential benefits and risks of different therapies to make choices that align with their individual needs and preferences. It's like choosing a path through a desert; careful planning and awareness of potential challenges are crucial for success.

Dr.Camel's Conclusion

This study provides a complex but crucial look at the use of mTORi in HCC treatment. While these medications hold promise for reducing recurrence, it's important to acknowledge their potential side effects and carefully consider the individual needs of each patient. It's a reminder that medical treatment, like a desert journey, often requires careful navigation and a balance between risk and reward.

Date :
  1. Date Completed 2022-12-26
  2. Date Revised 2022-12-26
Further Info :

Pubmed ID

36124430

DOI: Digital Object Identifier

10.1111/ctr.14823

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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