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Duration of Treatment With Glucocorticoids in Giant Cell Arteritis: A Systematic Review and Meta-analysis.

Author: BetrainsAlbrecht, BlockmansDaniel, MolenberghsGeert, MoreelLien, VanderschuerenSteven

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This meta-analysis estimated the mean duration of glucocorticoid (GC) treatment in patients with giant cell arteritis, finding that a considerable proportion of patients require prolonged GC treatment and that a predefined GC-tapering schedule may help to avoid overly long treatment.
Paper Details　
Original Abstract of the Article :
The aim of this meta-analysis was to estimate the mean duration of glucocorticoid (GC) treatment in patients with giant cell arteritis. PubMed, EMBASE, and Cochrane databases were searched from inception until November 30, 2021. The outcome measures were the proportion of patients on GCs at years 1,...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/36126266

データ提供：米国国立医学図書館（NLM）

Giant Cell Arteritis: A Chronic Journey with Glucocorticoids

Giant cell arteritis (GCA), a debilitating inflammatory condition primarily affecting the arteries, requires prolonged treatment with glucocorticoids (GCs). This meta-analysis meticulously examines the duration of GC treatment in patients with GCA, analyzing data from numerous studies to provide a comprehensive overview of this aspect of GCA management.

A Long Road to Recovery: The Duration of GC Treatment in GCA

This meta-analysis reveals that GCA is a chronic condition, requiring significant and prolonged GC treatment in a substantial proportion of patients. The authors found that nearly 90% of patients were still taking GCs after one year, with a significant number continuing treatment for two or even five years. These findings underscore the importance of careful GC management, balancing the need for effective treatment with the potential risks of long-term GC use.

Managing the Desert of GC Treatment: Balancing Benefits and Risks

This meta-analysis emphasizes the need for a balanced approach to GC management in GCA. While GC therapy offers substantial benefits in reducing inflammation and preventing complications, long-term use can lead to various side effects. The authors suggest that a predefined GC-tapering schedule may help to minimize the duration of GC treatment, potentially reducing the risk of long-term adverse effects. This research underscores the need for close monitoring and individualization of GC therapy in GCA patients.

Dr.Camel's Conclusion

Imagine a camel caravan traversing a vast desert, facing the challenges of heat, thirst, and fatigue. GC treatment for GCA is like a vital source of hydration, essential for survival but requiring careful management to avoid dehydration. This meta-analysis highlights the importance of navigating this journey with prudence, balancing the benefits of GC therapy with the potential risks of prolonged exposure. By understanding the nuances of GC treatment, we can optimize patient care and ensure a safe and effective journey through the desert of GCA.

Date :
  1. Date Completed 2023-10-09
  2. Date Revised 2023-10-09
Further Info :

Pubmed ID

36126266

DOI: Digital Object Identifier

00124743-990000000-00049

SNS
PICO Info
in preparation
Languages

English

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