Effect of Celecoxib Administration on the Skin of 40-Week-Old Mice.

Author: HiramotoKeiichi, MaruyamaKiyoko, OoiKazuya, TanakaShota

Paper Details 
Original Abstract of the Article :
Various side effects associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in analgesia have been reported. Among the NSAIDs, celecoxib has fewer side effects and is often used in therapeutic applications. However, the effect of celecoxib on aged skin is unknown. In this study, we...See full text at original site
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引用元:
https://doi.org/10.1248/bpb.b22-00518

データ提供:米国国立医学図書館(NLM)

Exploring the Effects of Celecoxib on Aging Skin

Aging is an inevitable part of life, like the slow erosion of a desert landscape over time. This study investigates the effects of celecoxib, a commonly used nonsteroidal anti-inflammatory drug (NSAID), on the skin of aged mice. The researchers explored whether celecoxib could have unintended consequences for aging skin, potentially leading to detrimental effects.

Navigating the Desert of Aging

The study found that celecoxib administration in aged mice led to a decrease in stratum corneum water content, potentially contributing to dry skin. Additionally, the study observed elevated serum hyaluronic acid, creatinine, and inflammatory cytokines, suggesting the onset of acute renal injury. The research, like a careful exploration of a desert ecosystem, reveals the complex interplay between drugs and aging processes.

A Cautionary Tale in the Desert of Aging

This study highlights the potential risks associated with celecoxib use in older individuals. While celecoxib is often considered a safe and effective NSAID, it is important to be aware of its potential side effects, particularly in aging populations. Consult with your healthcare provider to discuss any concerns about medication use and its potential impact on your health.

Dr.Camel's Conclusion

This research underscores the importance of considering the potential impact of medications on aging individuals. Just as a desert traveler must adapt to the harsh environment, aging individuals may require careful adjustments to their medication regimens to ensure optimal health and well-being.

Date :
  1. Date Completed 2022-12-02
  2. Date Revised 2022-12-02
Further Info :

Pubmed ID

36171113

DOI: Digital Object Identifier

10.1248/bpb.b22-00518

Related Literature

SNS
PICO Info
in preparation
Languages

English

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