Severe consumptive hypothyroidism in hepatic hemangioendothelioma.

Author: DubinskiIlja, HäberleBeate, KüppersJulia, LurzEberhard, SchmidIrene, SchmidtHeinrich, WaltherAntonia

Paper Details 
Original Abstract of the Article :
Consumptive hypothyroidism may occur in hepatic hemangioendothelioma. The altered expression of deiodinases inactivates peripheral thyroid hormones. As a result, serum levels of free triiodothyronine and free thyroxine are reduced to varying degrees. There are no established recommendations for the ...See full text at original site
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引用元:
https://doi.org/10.1515/jpem-2022-0347

データ提供:米国国立医学図書館(NLM)

Consumptive Hypothyroidism: A Rare and Complex Condition

The human body is a complex ecosystem, much like a vast desert with intricate relationships between its components. This research explores a rare and intriguing condition known as consumptive hypothyroidism, which can occur in individuals with hepatic hemangioendothelioma. The study highlights the crucial role of deiodinases, enzymes that regulate the activity of thyroid hormones, in this condition. The altered expression of these enzymes disrupts the delicate balance of thyroid hormones, leading to reduced levels of free triiodothyronine and free thyroxine. The study further explores the use of sirolimus, a medication typically used for other indications, as a potential treatment option for this condition. While there are no established recommendations for the dosage of sirolimus for this particular indication, this study provides a valuable case report on the successful use of low-dose sirolimus to manage this rare condition.

Sirolimus: A Potential Treatment for Consumptive Hypothyroidism

The use of sirolimus for consumptive hypothyroidism is a promising development. However, further research is necessary to establish optimal dosage and treatment protocols. This study provides a valuable starting point for future research in this area.

Navigating the Desert of Rare Diseases

Consumptive hypothyroidism is a rare condition, but it highlights the importance of understanding the intricate interplay of different systems in the human body. Researchers like those involved in this study are constantly exploring new frontiers in the desert of rare diseases, seeking to improve the lives of those affected by these challenging conditions.

Dr.Camel's Conclusion

This case report sheds light on a rare and complex condition, offering valuable insights into the potential therapeutic use of sirolimus for consumptive hypothyroidism. It emphasizes the importance of continuing research to understand and treat these less-common but often debilitating medical conditions.

Date :
  1. Date Completed 2022-12-02
  2. Date Revised 2022-12-02
Further Info :

Pubmed ID

36190305

DOI: Digital Object Identifier

10.1515/jpem-2022-0347

Related Literature

SNS
PICO Info
in preparation
Languages

English

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