Side Effects of liothyronine: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Main Research Findings

Liothyronine is a medication used to treat hypothyroidism, a condition caused by a deficiency of thyroid hormones. Hypothyroidism can cause symptoms such as fatigue, weight gain, and intolerance to cold. Liothyronine is an effective medication for improving these symptoms. 3 .

Liothyronine is also used to treat depression, which is a condition characterized by feelings of sadness, loss of interest, and decreased concentration and memory. Liothyronine is an effective medication for improving these symptoms. .

Liothyronine is also used to treat dementia, which is a disease characterized by a decline in cognitive function, including memory and thinking skills. Liothyronine is an effective medication for improving these symptoms. .

Liothyronine is also used as a treatment for other diseases. 5 .

Reasons for Side Effects

Liothyronine is a synthetic substance of triiodothyronine (T3), a type of thyroid hormone. T3 plays a vital role in the body's metabolism and growth. When liothyronine is taken, the body's T3 concentration increases, accelerating metabolism and growth. 1 .

Liothyronine is a synthetic substance of triiodothyronine (T3), a type of thyroid hormone. T3 plays a vital role in the body's metabolism and growth. When liothyronine is taken, the body's T3 concentration increases, accelerating metabolism and growth. 7 .

Common Side Effects

Tachycardia

Taking liothyronine can cause an increase in heart rate. This is because liothyronine stimulates the heart's activity. 3 .

Sweating

Taking liothyronine can make you sweat more easily. This is because liothyronine accelerates the body's metabolism. 3 .

Nervousness

Taking liothyronine can make you nervous. This is because liothyronine stimulates the brain's activity. 3 .

Insomnia

Taking liothyronine can make it difficult to fall asleep. This is because liothyronine accelerates the body's metabolism. 3 .

Weight Loss

Taking liothyronine can cause weight loss. This is because liothyronine accelerates the body's metabolism. 3 .

Osteoporosis

Taking liothyronine for extended periods can increase the risk of osteoporosis. This is because liothyronine affects bone metabolism. 3 .

Heart Disease

Taking liothyronine can increase the risk of heart disease. This is because liothyronine stimulates the heart's activity. 3 .

Side Effect Management

Tachycardia

It may be possible to alleviate the side effects by reducing the dosage of liothyronine or changing the time of administration. 3 .

Sweating

This can be improved by staying hydrated. 3 .

Nervousness

This can be improved by finding ways to relax. 3 .

Insomnia

This can be improved by finding ways to relax, such as drinking a warm glass of milk before bed or using aromatherapy. 3 .

Weight Loss

This can be improved by implementing dietary changes or exercise programs. 3 .

Osteoporosis

This can be prevented by consuming calcium and vitamin D. 3 .

Heart Disease

It is important to take steps to prevent heart disease, such as quitting smoking, engaging in moderate exercise, and maintaining a balanced diet. 3 .

Comparison of Studies

Commonalities in Research

Numerous studies have demonstrated that liothyronine is effective as a treatment for hypothyroidism. 6 .

Differences in Research

Research findings regarding the side effects of liothyronine vary among studies. 6 .

Precautions Regarding Real-Life Applications

Liothyronine is an effective medication for treating hypothyroidism. However, it is crucial to take it as prescribed by a physician due to the risk of side effects. 6 .

Limitations of Current Research

Research on the side effects of liothyronine is still insufficient. 6 .

Future Research Directions

Further research is needed to delve deeper into the side effects of liothyronine. 6 .

Conclusion

Liothyronine is an effective medication for treating hypothyroidism. However, it is crucial to take it as prescribed by a physician due to the risk of side effects. 6 .

Research on the side effects of liothyronine is still insufficient. Therefore, further research on the side effects of liothyronine is necessary. 6 .

Literature analysis of 8 papers
Positive Content
7
Neutral Content
0
Negative Content
1
Article Type
2
0
0
1
7
1.

Effect of Liothyronine Treatment on Quality of Life in Female Hypothyroid Patients With Residual Symptoms on Levothyroxine Therapy: A Randomized Crossover Study.

Author: BjerkreimBetty Ann, HammerstadSara Salehi, GulsethHanne Løvdal, BergTore Julsrud, OmdalLars Johan, Lee-ØdegårdSindre, EriksenErik Fink

Hypothyroid treatment
Hypothyroidism

This study aimed to evaluate the impact of LT3 monotherapy on quality of life (QoL) in hypothyroid patients who continued to experience symptoms despite having TSH levels within the reference range, even after LT4 monotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Severe consumptive hypothyroidism in hepatic hemangioendothelioma.

Author: WaltherAntonia, HäberleBeate, KüppersJulia, LurzEberhard, SchmidIrene, SchmidtHeinrich, DubinskiIlja

Hypothyroidism treatment

This study describes a case of consumptive hypothyroidism in a patient with hepatic hemangioendothelioma and the successful treatment with low-dose sirolimus.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

3.

[Rhabdomyolysis in a bodybuilder using steroids].

Author: DanielsJ M A, van WesterlooD J, de HonO M, FrissenP H J

Muscle cramps
Rhabdomyolysis

This case report describes a bodybuilder who experienced rhabdomyolysis, a breakdown of muscle tissue, following the use of anabolic steroids and other performance-enhancing substances.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Dutch

4.

Preventive effect of liothyronine on electroconvulsive therapy-induced memory deficit in patients with major depressive disorder: a double-blind controlled clinical trial.

Author: MohagheghiArash, ArfaieAsghar, AmiriShahrokh, NouriMasoud, AbdiSalman, SafikhanlouSalman

Prevent memory impairment

Liothyronine may prevent memory impairment caused by electroconvulsive therapy (ECT) in patients with major depressive disorder (MDD). In a double-blind clinical trial with 60 patients, the liothyronine group showed significantly higher scores in delayed recall, verbal memory, visual memory, general memory, and attention/concentration compared to the placebo group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Liquid liothyronine to obtain target TSH in differentiated thyroid cancer patients.

Author: TrimboliPierpaolo, CentanniMarco, ViriliCamilla

Achieved target TSH suppression
Individualized L-T3 dosage
Minimized side effects

This study found that liquid liothyronine (L-T3) was effective in achieving target TSH suppression in high-risk differentiated thyroid cancer patients whose TSH levels were not suppressed by levothyroxine alone. The liquid formulation allows individual dose adjustments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Risks and safety of combination therapy for hypothyroidism.

Author: JonklaasJacqueline

Hypothyroidism treatment

This review discusses the current treatment of hypothyroidism, highlighting the limitations of levothyroxine monotherapy and the increasing interest in combination therapy with levothyroxine and liothyronine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Self-Reported Allergy to Thyroid Replacement Therapy: A Multicenter Retrospective Chart Review.

Author: Chamorro-ParejaNatalia, Carrillo-MartinIsmael, HaehnDaniela A, WestphalSydney A, ParkMiguel A, BernetVictor J, Gonzalez-EstradaAlexei

Hypothyroidism treatment
Drug reaction

This study explores patterns of adverse drug reactions, including immediate hypersensitivity and predictable reactions, to thyroid replacement therapy (TRT), specifically levothyroxine (LT4), which is widely prescribed in the United States. While immediate hypersensitivity reactions are rare, the study aims to identify common patterns of adverse reactions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

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