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Therapeutic Reference Range for Aripiprazole in Schizophrenia Revised: a Systematic Review and Metaanalysis.

Author: ClementHans Willi, ConcaAndreas, EichentopfLuzie, FaltracoFrank, FlorioVincenzo, GründerGerhard, GrünerJessica, HartXenia M, Havemann-ReineckeUrsula, HiemkeChristoph, LenseXenija M, MoldenEspen, PaulzenMichael, RiemerThomas G, SchoretsanitisGeorgios

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This meta-analysis investigated the relationship between blood levels of aripiprazole, its target engagement in the human brain, and clinical effects and side effects in patients with schizophrenia and related disorders. The study found conflicting evidence for a relationship between concentration, efficacy, and side effects. However, population-based reference ranges suggest a therapeutic reference range of 120-270 ng/ml for aripiprazole and 180-380 ng/ml for its active moiety.
Paper Details　
Original Abstract of the Article :
RATIONALE: While one of the basic axioms of pharmacology postulates that there is a relationship between the concentration and effects of a drug, the value of measuring blood levels is questioned by many clinicians. This is due to the often-missing validation of therapeutic reference ranges. OBJECT...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9584998/

データ提供：米国国立医学図書館（NLM）

Finding the Right Dose: Aripiprazole Levels in Schizophrenia

This research delves into the complex world of pharmacology, specifically exploring the relationship between drug concentration and its effects. The study focuses on aripiprazole, a medication commonly used to treat schizophrenia, and aims to identify the optimal blood levels for effective treatment. The authors employed a systematic review and meta-analysis of existing studies, examining the relationship between aripiprazole levels in the blood, its activity in the brain, and clinical outcomes. This thorough analysis highlights the importance of finding the sweet spot for aripiprazole, which is not a one-size-fits-all approach, as individual responses can vary significantly.

Aripiprazole Blood Levels: Finding the Right Balance

The research concluded that a therapeutic reference range for aripiprazole, the medication itself, should be between 120-270 ng/ml, while the active moiety, the form that actually acts in the body, should be between 180-380 ng/ml. This means that finding the right dose for each individual patient is crucial to ensure optimal therapeutic effects.

Balancing Benefits and Risks: Aripiprazole and Individualized Treatment

The research emphasizes that achieving effective treatment for schizophrenia requires carefully monitoring aripiprazole levels in each individual. Understanding that individual responses to medications can vary significantly, especially given the influence of factors like genetics, is paramount for achieving optimal treatment outcomes.

Dr.Camel's Conclusion

This study is a great example of how finding the right dose for each individual is crucial to achieve optimal therapeutic effects. Just like in the desert, where each oasis has its own unique characteristics, each person's response to medication is unique. Finding the right dose is like finding the right oasis for your specific needs. It's a quest for balance, and this research offers valuable insight into finding that balance for aripiprazole treatment.

Date :
  1. Date Completed 2022-10-24
  2. Date Revised 2022-10-24
Further Info :

Pubmed ID

36195732

DOI: Digital Object Identifier

PMC9584998

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