Side Effects of sage: A Synthesis of Findings from 11 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of sage: A Synthesis of Findings from 11 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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Original Abstract of the Article

Main Research Findings

Sage has traditionally been used to treat neurological disorders. Sage has been shown to have anxiolytic, anti-inflammatory, antioxidant, and neuroprotective effects. Sage has also shown potential in treating common neurological disorders, including Alzheimer's disease, Parkinson's disease, migraine, and cognitive disorders. Sage has gained enormous popularity worldwide due to its availability, affordability, and few side effects.

Reasons for Side Effects

The reasons for sage side effects are not fully understood yet. However, sage contains various bioactive ingredients, and these ingredients may cause side effects. Additionally, sage may interact with other medications. 1 Therefore, it is important to consult with your doctor before using sage.

Common Side Effects

Digestive System

Sage may affect the digestive system. Symptoms such as nausea, vomiting, and diarrhea may occur. Additionally, sage may worsen stomach ulcers and duodenal ulcers.

Nervous System

Sage may affect the nervous system. Symptoms such as headache, dizziness, and drowsiness may occur. Additionally, sage may trigger seizures.

Allergies

Sage may cause allergic reactions. Symptoms such as itching, rash, and difficulty breathing may occur.

Side Effect Countermeasures

Digestive System

To prevent digestive system side effects, it is important to start with small amounts of sage. Additionally, it is important to stay hydrated while taking sage. If you have stomach ulcers or duodenal ulcers, you should avoid using sage.

Nervous System

To prevent nervous system side effects, you should avoid driving or operating machinery while taking sage. Additionally, you should avoid taking sage with sleeping pills or sedatives. If you have had seizures, you should avoid using sage.

Allergies

If you experience allergic reactions to sage, stop taking it and consult a doctor.

Comparison Between Studies

Commonalities

Multiple studies have shown that sage has the potential to be effective for a variety of neurological disorders. Furthermore, sage is generally considered a safe herb.

Differences

The results of studies on sage side effects vary. Some studies have shown that sage can affect the digestive and nervous systems. However, other studies have stated that sage side effects are rarely observed.

Cautions Regarding Application in Real Life

Although sage is considered a safe herb, it may cause side effects. It is important to consult your doctor before using sage. Additionally, pregnant or breastfeeding women and children should avoid using sage.

Limitations of Current Research

Research on sage side effects is still insufficient. Further research is needed.

Future Research Directions

Research on sage side effects needs to investigate the effects of the various components of sage. Additionally, further research is needed on the long-term effects of sage.

Conclusion

Sage is a herb that has traditionally been used to treat neurological disorders. Sage has shown potential to be effective for various neurological disorders. However, it may cause side effects. It is important to consult your doctor before using sage.

Literature analysis of 11 papers
Positive Content
9
Neutral Content
0
Negative Content
2
Article Type
1
1
1
3
11
4.

Role of trazodone in treatment of major depressive disorder: an update.

Author: FagioliniAndrea, González-PintoAna, MiskowiakKamilla Woznica, MorgadoPedro, YoungAllan H, VietaEduard

MDD treatment
Side effects

This narrative review summarizes recent clinical trials and real-world data on trazodone, a triazolopyridine serotonin receptor antagonist and reuptake inhibitor (SARI) antidepressant. Trazodone has established efficacy comparable to other available antidepressants and is effective for a range of depression symptoms, including insomnia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Post COVID-19 Vaccination Side Effects and Associated Factors Among Vaccinated Clients in Bahir Dar City, Ethiopia.

Author: SirajEbrahim Abdela, YayehradAshagrachew Tewabe, YilmaZewdu, GetahunTamyalew, MelakuMequannent Sharew, BizunehGizachew Kassahun, KifleZemene Demelash, YimenuDawit Kumilachew

Side effects

A significant proportion (17.4%) of participants reported at least one side effect following COVID-19 vaccination. Female participants, those with a history of regular medication use, participants aged 55 and above, and those who had taken only the first dose were more likely to experience side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Determinants of COVID-19 Vaccine Acceptance among Dental Professionals: A Multi-Country Survey.

Author: NassaniMohammad Zakaria, NoushadMohammed, RastamSamer, HussainMudassir, AlsalhaniAnas B, Al-SaqqafInas Shakeeb, AlaliFaisal Mehsen, DemachkiaAmir Mohiddin, de MeloRenata Marques, ArshadMohammed, LuddinNorhayati, HuseinAdam, QamarZeeshan, KoppoluPradeep, DarwishMahmoud, NassarAhmad Salim Abdalla, HabibAdnan, SuleymanFiras, KhanamH M Khuthija, YousiefSalah A, Al-MaweriSadeq Ali, TabassumNafeesa, SamranAbdulaziz, DimashkiehMohiddin R, Al-AwarMohammed Sadeg, TarakjiBassel

Vaccine acceptance
Lower acceptance in low-income countries

This study surveyed dentists and dental students in seven countries to assess COVID-19 vaccine acceptance rates. Overall, 72.5% of respondents reported they would accept the vaccine, but acceptance rates varied significantly across countries, with higher rates in upper-middle- and high-income countries. Factors associated with higher vaccine acceptance included being a dentist, being free of comorbidity, being well-informed about the vaccine, and having anxiety about COVID-19 infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Efficacy and Safety of Daridorexant in Older and Younger Adults with Insomnia Disorder: A Secondary Analysis of a Randomised Placebo-Controlled Trial.

Author: FietzeIngo, BassettiClaudio L A, MaylebenDavid W, PainScott, Seboek KinterDalma, McCallWilliam V

Daytime functioning
Improved sleep

This analysis further analyzed a phase III trial studying the higher doses of the dual orexin receptor antagonist daridorexant, which showed efficacy in adults with insomnia. The analysis compared the safety and efficacy of daridorexant in patients aged ≥ 65 years ('older adults') to those aged < 65 years ('younger adults').

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Therapeutic Reference Range for Aripiprazole in Schizophrenia Revised: a Systematic Review and Metaanalysis.

Author: HartXenia M, HiemkeChristoph, EichentopfLuzie, LenseXenija M, ClementHans Willi, ConcaAndreas, FaltracoFrank, FlorioVincenzo, GrünerJessica, Havemann-ReineckeUrsula, MoldenEspen, PaulzenMichael, SchoretsanitisGeorgios, RiemerThomas G, GründerGerhard

Schizophrenia treatment

This meta-analysis investigated the relationship between blood levels of aripiprazole, its target engagement in the human brain, and clinical effects and side effects in patients with schizophrenia and related disorders. The study found conflicting evidence for a relationship between concentration, efficacy, and side effects. However, population-based reference ranges suggest a therapeutic reference range of 120-270 ng/ml for aripiprazole and 180-380 ng/ml for its active moiety.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Reason and Associated Factors for Nonuse of Contraceptives Among Ethiopian Rural Married Women: A Multilevel Mixed Effect Analysis.

Author: MulugetaSolomon Sisay, MulunehMitiku Wale, BelayAlebachew Taye, YalewMequanint Melkam, AgegnSetegn Bayabile

Contraception use
Breastfeeding
Fear of side effects

Nonuse of modern contraceptives is high among Ethiopian rural married women, particularly due to fear of side effects and breastfeeding. Interventions should target younger women, those living in rural areas, the poor, and Muslim women.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Zuranolone: The First FDA-Approved Oral Treatment Option for Postpartum Depression.

Author: BarnesKylie N, VoglClaire M, NelsonLeigh Anne

Oral administration
Rapid onset of effect

Zuranolone, an oral medication, is a rapid-acting treatment for postpartum depression (PPD) and is effective in improving depressive symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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