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Meloxicam loaded hydroxypropyl methylcellulose (HPMC) microparticulate: Fabrication, characterization and in vivo pharmacokinetic assessment.

Author: AchakzaiJahangir Khan, AhmadRabbiya, AkhtarMuhammad, JanSyed Umer, MuhammadShafi, RazaqueGhulam, ShahPervaiz Akhtar, ShahwaniGhulam Mustafa, ShahwaniNisar Ahmad, WasaySyed Abdul, YounisMohammad

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Meloxicam, a COX-2 inhibitor for colorectal cancer, has low water solubility. HPMC microparticles were developed to improve meloxicam delivery and release. The microparticles transformed meloxicam from crystalline to amorphous, increasing drug release by up to 86%. In vivo studies in rabbits showed significantly increased C<sub>max</sub> and half-life for the microparticles compared to pure meloxicam, suggesting improved therapeutic efficacy and reduced side effects.
Paper Details　
Original Abstract of the Article :
Meloxicam (MEL) is an oxicam derivative with low water solubility that is useful in the treatment of colorectal cancer (CRC) as a COX-2 inhibitor. MEL-loaded HPMC micro particles were fabricated using an oil-in-oil (o/o) emulsion solvent evaporation (ESE) method. FTIR, XRD, particle size analysis, D...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/36218104

データ提供：米国国立医学図書館（NLM）

Meloxicam Loaded Hydroxypropyl Methylcellulose (HPMC) Microparticulate: Fabrication, Characterization, and In Vivo Pharmacokinetic Assessment

Meloxicam, a widely used drug for treating colorectal cancer, often poses challenges due to its poor water solubility. This study explores the potential of using HPMC microparticles to enhance the delivery and bioavailability of meloxicam, aiming to improve its therapeutic efficacy and reduce side effects. The researchers meticulously fabricated and characterized these microparticles, evaluating their properties and pharmacokinetic performance in an animal model.

Enhancing Meloxicam Delivery: A Desert Oasis of Innovation

The study successfully fabricated meloxicam-loaded HPMC microparticles using an oil-in-oil emulsion solvent evaporation method. The microparticles exhibited desirable characteristics, including a smooth, spherical shape, controlled drug release, and improved pharmacokinetic performance in rabbits. These findings suggest that meloxicam-loaded HPMC microparticles could significantly enhance the delivery and efficacy of this important anti-cancer drug.

Navigating the Sands of Drug Delivery: Improving Patient Outcomes

The study's findings hold significant implications for drug delivery research and the development of more effective and patient-friendly therapeutic approaches. Just as a traveler in the desert relies on reliable water sources to sustain their journey, patients with colorectal cancer require effective drug delivery systems to ensure optimal treatment outcomes. This study offers a promising approach to improving the delivery of meloxicam, potentially leading to better therapeutic responses and fewer side effects.

Dr. Camel's Conclusion

The study's findings highlight the potential of nanotechnology to improve drug delivery and enhance treatment outcomes. The development of meloxicam-loaded HPMC microparticles offers a promising solution to overcome the challenges associated with this important anti-cancer drug. As we continue to explore the vast landscape of drug delivery research, we can work towards a future where treatments are more effective, targeted, and personalized to meet the specific needs of each patient.
Date :
  1. Date Completed 2022-10-12
  2. Date Revised 2022-10-12
Further Info :

Pubmed ID

36218104

DOI: Digital Object Identifier

36218104

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Languages

English

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