Paper Details

  1. Home
  2. Paper Details

Dermal Safety of Tapinarof Cream 1%: Results From 4 Phase 1 Trials.

Author: DellaMaestraWayne, JettJohn, McLaughlinMichael, PiscitelliStephen, RubensteinDavid, SomervilleMatthew, WilsonTimothy

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study evaluated the safety and tolerability of tapinarof cream 1%, a novel topical aryl hydrocarbon receptor agonist, in four dermal safety trials in healthy adults. The study found that tapinarof cream 1% was well tolerated, non-sensitizing, non-phototoxic, and non-photoallergic, with no evidence of clinically meaningful cumulative skin irritation.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Tapinarof (VTAMA®; Dermavant Sciences, Inc.) is a novel, non-steroidal, topical, aryl hydrocarbon receptor agonist, FDA approved for psoriasis treatment and under investigation for atopic dermatitis treatment as a 1% cream formulation for once-daily (QD) application. OBJECTIVE: Eval...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.36849/JDD.6627

データ提供：米国国立医学図書館（NLM）

The Dermal Safety of Tapinarof Cream

This research dives into the world of dermatology, specifically investigating the safety of a new topical cream called tapinarof. The researchers used a variety of methods to study the potential for skin irritation, sensitization, and photoallergic and phototoxic reactions. They performed four separate trials, each examining different aspects of tapinarof's safety profile. The results of these trials were quite positive, demonstrating that tapinarof cream was well-tolerated by the study participants. It appears that tapinarof cream is a promising new treatment for various skin conditions, offering a potential alternative to steroid-based creams.

Tapinarof Cream - A Safe and Effective Option

The research found that tapinarof cream 1% showed only a slight potential for very mild cumulative irritation when applied daily for 21 days under occlusive conditions. This finding indicates that tapinarof cream is generally well-tolerated, even when applied frequently. Further, no evidence of sensitization, photosensitization, or phototoxicity was found, suggesting that tapinarof cream is safe for use by a wide range of individuals, even those with sensitive skin.

Skin Health & Tapinarof Cream

It's good news for those seeking safe and effective treatments for skin conditions. Tapinarof cream presents a promising new option, especially for people who may be sensitive to traditional treatments. However, it's always important to consult with a healthcare professional before starting any new treatment, especially if you have concerns about skin sensitivity or allergies.

Dr.Camel's Conclusion

Imagine a thirsty camel crossing a vast desert - it needs a safe and reliable water source. Tapinarof cream is like a refreshing oasis for your skin, offering a gentle and effective solution for various skin conditions. This research provides valuable insights into the safety and potential benefits of tapinarof cream, paving the way for further exploration of this promising treatment.
Date :
  1. Date Completed 2022-10-13
  2. Date Revised 2022-10-17
Further Info :

Pubmed ID

36219046

DOI: Digital Object Identifier

10.36849/JDD.6627

Related Literature

Article Analysis
・Effects of tapinarof topical
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.