Effects of tapinarof topical: A Synthesis of Findings from 19 Studies

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Original Abstract of the Article

Major Research Findings

Tapinarof topical cream is a novel, non-steroidal, aryl hydrocarbon receptor agonist that has shown promising results in the treatment of plaque psoriasis. 19 、 13 、 12 、 11 、 14 、 7 Clinical trials have demonstrated its effectiveness in achieving skin clearance and improving symptoms. 19 、 12 、 14 、 7 Moreover, tapinarof topical cream appears to be well-tolerated with a low risk of side effects compared to traditional steroid topical treatments. 12 、 14 、 7

Benefits and Risks

Benefit Summary

Tapinarof topical cream is a promising treatment option for plaque psoriasis, offering effective symptom relief and skin clearance with a favorable safety profile. 12 、 14 、 7 Its non-steroidal nature makes it a suitable alternative for patients who cannot tolerate or have concerns about long-term use of steroid topicals. 12 、 14 、 7

Risk Summary

While tapinarof topical cream is generally well-tolerated, it's important to be aware of potential side effects. 12 、 14 、 7 Common side effects include skin redness, itching, and dryness. 12 、 14 、 7 Additionally, tapinarof topical cream is not recommended for use during pregnancy or breastfeeding. 12 、 14 、 7 Always consult with a doctor before using tapinarof topical cream.

Study Comparisons

Study Commonalities

Multiple studies consistently show that tapinarof topical cream is effective in treating plaque psoriasis. 19 、 13 、 12 、 11 、 14 、 7 Furthermore, these studies indicate that tapinarof topical cream is generally safe. 12 、 14 、 7

Study Differences

The effectiveness and side effects of tapinarof topical cream can vary depending on the study. 13 These differences may be due to variations in study design, participant characteristics, and other factors. 13 Therefore, further research is necessary to comprehensively assess the effectiveness and side effects of tapinarof topical cream.

Consistency and Contradictions in Results

The majority of studies demonstrate the effectiveness of tapinarof topical cream in treating plaque psoriasis. 19 、 13 、 12 、 11 、 14 、 7 However, some studies suggest that tapinarof topical cream might worsen psoriasis symptoms in a specific mouse model. 13 This finding indicates that tapinarof topical cream might have varying effects depending on the type of psoriasis. 13

Considerations for Real-World Application

While promising, tapinarof topical cream may not be effective for everyone. 13 Additionally, there are potential side effects to consider. 12 、 14 、 7 Therefore, always consult a doctor before using tapinarof topical cream and follow their instructions carefully.

Limitations of Current Research

Research on tapinarof topical cream is still in its early stages. 13 Further research is required to comprehensively evaluate its long-term effectiveness, safety, efficacy for different types of skin diseases, and the effects of combining it with other treatments. 13

Future Research Directions

Further research is needed to evaluate the long-term effectiveness and safety of tapinarof topical cream, as well as its efficacy in treating various skin diseases. 13 Additional research is also required to explore the potential impact of tapinarof topical cream on different types of psoriasis and its effectiveness when used in combination with other treatments. 13

Conclusion

Tapinarof topical cream is a promising new treatment option for plaque psoriasis, offering effective symptom relief and skin clearance with a favorable safety profile. 12 、 14 、 7 However, research is ongoing, and further studies are needed to assess its long-term efficacy and safety. 13 If you are considering using tapinarof topical cream, consult with a doctor to determine if it is appropriate for you. 13

Literature analysis of 19 papers
Positive Content
18
Neutral Content
1
Negative Content
0
Article Type
6
1
2
10
19
1.

A randomised, placebo-controlled trial comparing the effects of tapentadol and oxycodone on gastrointestinal and colonic transit in healthy humans.

Author: JeongI D, CamilleriM, ShinA, IturrinoJ, BoldinghA, BusciglioI, BurtonD, RyksM, RhotenD, ZinsmeisterA R

Pain relief
GI side effects

This study investigates the effects of tapentadol, a mu-opioid receptor agonist and norepinephrine reuptake inhibitor, on gastrointestinal and colonic transit. The study aims to understand the impact of tapentadol on digestion and bowel movements.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Undesired side effects of tapentadol in comparison to oxycodone. A meta-analysis of randomized controlled comparative studies].

Author: MerkerM, DingesG, KochT, KrankeP, MorinA M

Less GI side effects
Pain relief

This study reviewed randomized controlled trials comparing tapentadol and oxycodone for pain management. The objective was to evaluate the relative amount of adverse effects associated with each drug.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : German

3.

Miotic and subject-rated effects of therapeutic doses of tapentadol, tramadol, and hydromorphone in occasional opioid users.

Author: StoopsWilliam W, GlaserPaul E A, RushCraig R

Tapentadol analgesia
Tramadol side effects

Tapentadol, a novel analgesic, produced a profile of positive effects comparable to hydromorphone. Tramadol, another analgesic, produced both positive and negative subject-rated effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Tapentadol versus oxycodone analgesia and side effects after laparoscopic hysterectomy: A randomised controlled trial.

Author: ComelonMarlin, RaederJohan, DrægniTomas, LiengMarit, LenzHarald

Reduced side effects
Synergistic analgesia

Tapentadol, an opioid with a dual mechanism of action, was investigated for its effectiveness in postoperative pain management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Tapentadol results in less deterioration of gastrointestinal function and symptoms than standard opioid therapy in healthy male volunteers.

Author: MarkEsben Bolvig, NedergaardRasmus Bach, HansenTine Maria, NissenThomas Dahl, FrøkjaerJens Brøndum, ScottS Mark, KroghKlaus, DrewesAsbjørn Mohr

Improved pain management
Reduced GI side effects

This study aims to investigate the effects of tapentadol and oxycodone on gastrointestinal motility and side effects, focusing on a more precise assessment of mechanistic effects and comparisons with other opioids or placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Management of Plaque Psoriasis in Adults: Clinical Utility of Tapinarof Cream.

Author: SpencerRiley K, JinJoy Q, ElhageKareem G, DavisMitchell S, LiaoWilson, BhutaniTina

Effective psoriasis treatment
Good skin tolerability
Long-lasting effect

Tapinarof, a novel topical aryl hydrocarbon receptor (AHR) agonist, has been approved by the FDA for the treatment of plaque psoriasis. Clinical trials have shown its efficacy, good local tolerability, and a long duration of effect, offering a new non-steroidal option for psoriasis treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

New Non-Steroidal Topical Therapies for Inflammatory Dermatoses-Part 3: Roflumilast.

Author: DiRuggieroMargaret, Mancuso-StewartElizabeth, DiRuggieroDouglas, ZirwasMatt

Dermatitis treatment
Non-steroidal topicals
None mentioned

Topical roflumilast is a highly potent phosphodiesterase-4 inhibitor that has recently been approved by the FDA for the treatment of plaque psoriasis. This review summarizes the data surrounding topical roflumilast, providing an overview of its unique mechanism of action, clinical characteristics, efficacy, safety, and tolerability profiles.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

New Non-Steroidal Topical Therapies for Inflammatory Dermatoses-Part 2: Tapinarof.

Author: DiRuggieroMargaret, Mancuso-StewartElizabeth, DiRuggieroDouglas, ZirwasMatt

High tolerability
Rapid onset of action
Topical treatment

Topical tapinarof, an aryl hydrocarbon receptor modulating agent, was approved by the FDA in May 2022 for treating plaque psoriasis. This non-steroidal topical medication provides a new treatment option for psoriasis, with a unique mechanism of action and clinical characteristics, including high efficacy, rapid onset of action, potential remittive effects, and a favorable safety and tolerability profile.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

A Review of Tapinarof: Novel Topical Treatment for Plaque Psoriasis in Adults.

Author: Kalabalik-HogansonJulie, NogidAnna, FreyKathleen

Psoriasis treatment

Tapinarof is a novel topical aryl hydrocarbon receptor modulating drug approved for plaque psoriasis in adults. This review summarizes preclinical and clinical studies demonstrating its efficacy and safety, positioning tapinarof as a promising treatment option for patients with plaque psoriasis.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Tapinarof for the treatment of psoriasis.

Author: NogueiraSofia, RodriguesMaria Alexandra, VenderRon, TorresTiago

Psoriasis treatment
Contact dermatitis
Folliculitis
Headache
Pruritus
Upper respiratory tract infection

This review discusses tapinarof, a novel topical therapeutic AhR-modulating agent recently approved for the treatment of plaque psoriasis. Clinical trials showed tapinarof 1% cream to be effective and safe, representing an alternative to current topical psoriasis treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Dermal Safety of Tapinarof Cream 1%: Results From 4 Phase 1 Trials.

Author: JettJohn, McLaughlinMichael, WilsonTimothy, SomervilleMatthew, DellaMaestraWayne, RubensteinDavid, PiscitelliStephen

Non-photoallergic
Non-phototoxic
Non-sensitizing
Well tolerated
Mild cumulative irritation

This study evaluated the safety and tolerability of tapinarof cream 1%, a novel topical aryl hydrocarbon receptor agonist, in four dermal safety trials in healthy adults. The study found that tapinarof cream 1% was well tolerated, non-sensitizing, non-phototoxic, and non-photoallergic, with no evidence of clinically meaningful cumulative skin irritation.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

What's New in Topicals for Atopic Dermatitis?

Author: KleinmanElana, LaboradaJennifer, MetterleLauren, EichenfieldLawrence F

Improved efficacy
Novel AD treatments
Reduced adverse effects
Long-term safety unknown

This review highlights novel topical treatments for atopic dermatitis (AD) that are in later phases of development, including Janus kinase inhibitors, phosphodiesterase-4 inhibitors, aryl hydrocarbon modulators, and microbiome modulators.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

New Topical Therapies in Development for Atopic Dermatitis.

Author: FreitasEgídio, GooderhamMelinda, TorresTiago

Treat atopic dermatitis

This review discusses topical treatments for atopic dermatitis (AD), highlighting the limitations of current therapies like corticosteroids and calcineurin inhibitors. The authors examine the potential of new topical compounds, including ruxolitinib, tapinarof, difamilast, and roflumilast, for treating mild to moderate AD. However, they emphasize the need for larger, long-term studies to assess their efficacy and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

An overview of benvitimod for the treatment of psoriasis: a narrative review.

Author: LuSarah T, KellyKatherine A, FeldmanSteven R

Efficacious
Tolerable
Adverse effects

Topical corticosteroids are often used for psoriasis, but can have adverse effects with long-term use. Benvitimod, an aryl hydrocarbon receptor immunomodulator, is effective and well-tolerated for mild to severe psoriasis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Phase 3 Trials of Tapinarof Cream for Plaque Psoriasis.

Author: LebwohlMark G, Stein GoldLinda, StroberBruce, PappKim A, ArmstrongApril W, BagelJerry, KircikLeon, EhstBenjamin, HongH Chih-Ho, SoungJennifer, FromowitzJeff, GuenthnerScott, PiscitelliStephen C, RubensteinDavid S, BrownPhilip M, TallmanAnna M, BissonnetteRobert

Reduced psoriasis severity
Headache
Local adverse events

Two phase 3 trials evaluated the efficacy and safety of tapinarof 1% cream for treating plaque psoriasis. Tapinarof demonstrated significantly greater improvement in psoriasis severity compared to vehicle control after 12 weeks. However, local adverse events and headache were reported. Further research is needed to compare tapinarof with existing treatments.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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