Tapinarof for the treatment of psoriasis.

Author: NogueiraSofia, RodriguesMaria Alexandra, TorresTiago, VenderRon

Paper Details 
Original Abstract of the Article :
Although topical drugs are the mainstay of treatment for patients with mild-to-moderate psoriasis, the developments observed in this field in the last two decades have been limited. The most commonly used drugs are still vitamin D analogues and corticosteroids, both with several limitations. The ary...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078538/

データ提供:米国国立医学図書館(NLM)

Tapinarof: A New Hope for Psoriasis Treatment

The [treatment of psoriasis] has long relied on topical medications, but progress has been limited. This study introduces tapinarof, a novel topical therapeutic agent, as a promising new option for patients with mild-to-moderate plaque psoriasis. This drug works by modulating the aryl hydrocarbon receptor (AhR), a key player in the pathogenesis of psoriasis.

The researchers conducted two large phase III trials that demonstrated tapinarof's effectiveness. A significant percentage of patients treated with tapinarof 1% cream achieved the primary endpoint, compared to a much smaller percentage in the vehicle group. While side effects like folliculitis and contact dermatitis were observed, they were considered manageable.

Tapinarof: A New Frontier in Psoriasis Management

The study findings suggest that tapinarof represents a valuable addition to the therapeutic armamentarium for psoriasis, offering an alternative to existing options like vitamin D analogues and corticosteroids. The promising efficacy and favorable safety profile suggest that tapinarof could significantly impact the lives of many patients seeking relief from psoriasis.

Living with Psoriasis: A New Perspective

The development of tapinarof provides hope for those living with psoriasis. This new medication, much like a refreshing oasis in a parched desert, offers a potentially effective and safe alternative to existing treatments. It is crucial to consult with a dermatologist to determine if tapinarof is the right treatment option for you.

Dr.Camel's Conclusion

The journey to finding effective treatments for psoriasis can feel like navigating a desert, with many obstacles and limited resources. Tapinarof, like a new trail blazed across the dunes, offers a glimmer of hope for those seeking relief from this debilitating skin condition. It is a testament to the ongoing efforts to improve patient care and provide better treatment options for those living with psoriasis.

Date :
  1. Date Completed 2022-12-30
  2. Date Revised 2023-04-11
Further Info :

Pubmed ID

36226669

DOI: Digital Object Identifier

PMC10078538

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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