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Efficacy of a triamcinolone acetonide-loaded dissolving microneedle patch for the treatment of hypertrophic scars and keloids: a randomized, double-blinded, placebo-controlled split-scar study.

Author: DisphanuratWareeporn, LeelawattanachaiJeerapond, SivapornpanNakarin, SrisantithumBenjaporn

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study compares the efficacy of a triamcinolone acetonide (TAC)-dissolving microneedle (DMN) patch to a drug-free DMN patch for treating hypertrophic scars (HTSs) and keloids. TAC is a common treatment for these conditions but has potential side effects. DMNs can enhance drug delivery to the dermis without causing pain or increasing the risk of infection. This study found that TAC-DMNs significantly reduced scar volume in HTSs, suggesting its potential as an effective treatment option. Further research is needed to optimize the treatment of keloids.
Paper Details　
Original Abstract of the Article :
The treatment of hypertrophic scars (HTSs) and keloids remains a challenge. Intralesional triamcinolone acetonide (TAC) is the mainstay treatment for these conditions. Despite its efficacy, TAC has several adverse side effects, including telangiectasias, skin atrophy, pigmentary changes, and skin ne...See full text at original site
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引用元：
https://doi.org/10.1007/s00403-022-02473-6

データ提供：米国国立医学図書館（NLM）

Triamcinolone Acetonide Microneedle Patch: A New Approach to Scar Treatment

Hypertrophic scars and keloids can be a significant cosmetic and psychological burden for patients. This study explores the efficacy of a triamcinolone acetonide (TAC)-loaded dissolving microneedle (DMN) patch for treating these conditions. The researchers conducted a randomized, double-blinded, placebo-controlled split-scar study to evaluate the effectiveness of the TAC-DMN patch compared to a drug-free DMN patch.

A Novel Delivery System: Microneedles for Targeted Delivery

The study demonstrates the potential of TAC-loaded DMNs for treating hypertrophic scars. The microneedle technology, like tiny desert cacti, delivers the medication directly to the scar tissue, bypassing the skin barrier and enhancing drug penetration. The researchers found that the TAC-DMN patch was effective in reducing scar volume and improving the appearance of hypertrophic scars.

Navigating the Scarred Landscape: Hope for Improved Outcomes

This study offers a promising approach to treating hypertrophic scars. The findings suggest that the TAC-DMN patch could be a valuable tool for improving patient outcomes and reducing the burden of these conditions. While further research is needed to optimize treatment parameters and explore its effectiveness in keloids, this study provides a hopeful direction for scar management.

Dr.Camel's Conclusion

This study explores the potential of a triamcinolone acetonide (TAC)-loaded dissolving microneedle (DMN) patch for treating hypertrophic scars. The researchers demonstrate the efficacy of the TAC-DMN patch in reducing scar volume and improving appearance. This novel approach, like a gentle desert breeze, offers a promising path towards better management of scars. The study reminds us that innovation in drug delivery can lead to improved patient outcomes and a brighter future for those affected by hypertrophic scars.

Date :
  1. Date Completed 2023-04-12
  2. Date Revised 2023-04-12
Further Info :

Pubmed ID

36383222

DOI: Digital Object Identifier

10.1007/s00403-022-02473-6

Related Literature

Article Analysis
・Side Effects of triamcinolone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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