Side Effects of triamcinolone: A Synthesis of Findings from 24 Studies

  1. Home
  2. Side Effects of triamcinolone
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of triamcinolone: A Synthesis of Findings from 24 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of triamcinolone: A Synthesis of Findings from 24 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Triamcinolone is a corticosteroid used to treat a variety of inflammatory conditions, including eye conditions like diabetic macular edema ( 13 ) and uveitis ( 3 ), skin conditions like keloids ( 24 ), and even post-surgical pericardial effusion in children ( 1 ). These studies highlight the potential benefits of triamcinolone in various settings, while also emphasizing the need to understand its potential side effects.

Reasons for Side Effects

Triamcinolone's side effects are a consequence of its potent anti-inflammatory properties. While this is beneficial for treating inflammation, it can also suppress the immune system, leading to increased susceptibility to infections ( 18 , 3 ). Additionally, triamcinolone can affect various tissues in the body, leading to a range of side effects.

Common Side Effects

Eye Side Effects

Triamcinolone, when administered to the eyes, can lead to side effects such as cataracts and glaucoma ( 10 , 22 ). In the case of eye injury, it can also contribute to complications like retinal detachment and macular edema ( 20 ).

Skin Side Effects

Topical triamcinolone use can cause skin atrophy and pigmentation changes ( 15 , ). This is particularly relevant for treatment of keloids and hypertrophic scars.

Other Side Effects

Oral triamcinolone can lead to gastrointestinal issues like peptic ulcers and bone problems like osteoporosis ( 1 ). It can also affect the heart, potentially leading to cardiac complications when used to treat pericardium ( 21 ). Finally, triamcinolone can contribute to hypertension, as illustrated in a case report of a patient with pemphigus vulgaris ( 6 ).

Countermeasures for Side Effects

Eye Side Effects

Regular monitoring of eye pressure is crucial when using triamcinolone for eye conditions ( 22 ). Prompt treatment for any developing cataracts or glaucoma is essential.

Skin Side Effects

Discontinuation of triamcinolone is necessary if skin side effects occur (). Starting with low doses and gradually increasing them can minimize the risk of side effects.

Other Side Effects

Regular blood tests are recommended when taking triamcinolone orally ( 1 ). Prompt medical attention is needed for any gastrointestinal or bone problems that arise.

Comparison Between Studies

Similarities Among Studies

Most studies emphasize the efficacy of triamcinolone while acknowledging its potential side effects. The incidence of side effects can vary depending on the administration method and dosage.

Differences Between Studies

Variations in study design, participants, and administration methods can lead to different conclusions regarding the effectiveness and side effect profiles of triamcinolone.

Points to Note for Application in Everyday Life

Triamcinolone is a valuable treatment option, but it's crucial to be aware of its potential side effects. Always follow your doctor's instructions and discuss any concerns or side effects you experience. Never self-medicate with triamcinolone.

Limitations of Current Research

Long-term side effects of triamcinolone remain understudied, highlighting a gap in current research. Further investigation is needed to understand the long-term impact of triamcinolone use.

Future Research Directions

Developing safer administration methods and novel formulations of triamcinolone is crucial for minimizing side effects. Research focused on elucidating the mechanisms underlying triamcinolone side effects could lead to preventative measures.

Conclusion

Triamcinolone, a potent anti-inflammatory drug, offers significant therapeutic benefits but also carries the risk of side effects. Close collaboration with a healthcare professional is essential to maximize benefits while minimizing risks. Research continues to investigate triamcinolone's long-term effects, aiming to improve its safety and efficacy.

Literature analysis of 24 papers
Positive Content
22
Neutral Content
0
Negative Content
2
Article Type
5
0
0
2
19
3.

A Case of Vogt-Koyanagi-Harada Disease-Like Uveitis Induced by Nivolumab and Ipilimumab Combination Therapy.

Author: MinamiKeisuke, EgawaMariko, KajitaKeisuke, MuraoFumiko, MitamuraYoshinori

Early detection
VKH recurrence
Vision loss

This case report describes a patient with advanced melanoma who experienced recurrent Vogt-Koyanagi-Harada (VKH) disease-like uveitis after resuming nivolumab and ipilimumab treatment.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

4.

A Novel Method of Steroid Delivery to Improve the Efficacy of Intralesional Injection in Keloid Treatment.

Author: ChoMi Yeon, SongAhreum, ChungKee Yang, RohMi Ryung

Keloid reduction
Treatment interval

The tunneling method of corticosteroid injection was more effective and safer than the conventional method for the treatment of keloids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Early-Stage Primary Anti-inflammatory Therapy Enhances the Regenerative Efficacy of Platelet-Rich Plasma in a Rabbit Achilles Tendinopathy Model.

Author: RuanDengfeng, FeiYang, QianShengjun, HuangZizhan, ChenWeishan, TangChenqi, XiangXinyu, XuJialu, YinZi, ChenXiao, HengBoon Chin, LiuWanlu, ShenWeiliang, OuyangHongwei

Tendinopathy treatment

This study examines how the therapeutic effects of platelet-rich plasma (PRP) on tendinopathy are modulated by the inflammatory environment. While the inflammatory changes in tendinopathy are well characterized, the mechanisms behind PRP's effects are not well defined.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Pigmentary retinopathy associated with immune therapy for advanced cutaneous melanoma.

Author: LinAndrew C, ParkSoo J, DanielsGregory A, BorooahShyamanga

Retinal pigmentary changes

Immune checkpoint inhibitor therapy (ICIT) can lead to rare and potentially serious ophthalmologic complications, including bilateral retinal pigmentary changes.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

11.

Suprachoroidal injection of triamcinolone acetonide plus intravitreal bevacizumab in diabetic macular edema: a randomized pilot trial.

Author: FazelFarhad, MalekahmadiMohammad, FeiziAwat, OliyaBehrooz, TavakoliMehdi, FazelMohammadreza

Improved vision
Reduced retinal edema
None reported

This study investigated the efficacy of injecting suprachoroidal triamcinolone acetonide (SCTA) plus intravitreal bevacizumab (IVB) in patients with center-involving diabetic macular edema (CI-DME). The combination therapy showed significant improvements in best-corrected visual acuity (BCVA) and central subfield thickness (CST) compared to monotherapy with IVB alone. The combination therapy demonstrated additive effects with no short-term side effects and appears to be a promising treatment option for patients with CI-DME.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Clinical and biochemical assessment of the effect of topical use of coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus: randomized controlled clinical trial.

Author: AbdelsamieMostafa, ZahranFat'heya, HussineAmal A, ShakerOlfat, Al-MahallawiAbdulaziz Mohsen

Effective for oral lichen planus
Reduces side effects

This study compared the clinical therapeutic effect of topical coenzyme Q10 (coQ10) versus topical corticosteroids in the management of oral lichen planus (OLP). The study aimed to assess the efficacy of coQ10, potentially due to its antioxidant activity.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Oral Pemphigoid Recalcitrant Lesion Treated with PRGF Infiltration. Case Report.

Author: AnituaEduardo, AlkhraisatMohammad H, EguiaAsier, PiñasLaura

Lesion healing
Pain reduction
Successful MMP treatment

PRGF infiltrations successfully treated a recalcitrant mucous membrane pemphigoid (MMP) oral ulcerative lesion, demonstrating its potential as an adjuvant therapy for extensive MMP oral lesions.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

19.

Safety and efficacy of mesotherapy in the treatment of melasma: A review article.

Author: KhaliliMaryam, AmiriRezvan, IranmaneshBehzad, ZartabHamed, AflatoonianMahin

Melasma treatment
Side effects

Mesotherapy, a novel therapeutic approach involving intradermal or subcutaneous microinjections, is commonly used in aesthetic dermatology. This study reviewed the current understanding of mesotherapy for melasma, focusing on the details of injections, efficacy, and side effects. It aimed to provide a comprehensive overview of this technique and its application in treating melasma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Early use of intravitreal triamcinolone to inhibit traumatic proliferative vitreoretinopathy: a randomised clinical trial.

Author: GuoHaixia, YuJinguo, HeTiangeng, ChenSong, SunZhuoyu, ZhangJingkai, SunZhiyong, YangWenhui, YaoBaoqun, YangXueli, LiuYuanyuan, ZhangMingxue, MengYu, YangLikun, YanHua

OGI treatment
TPVR suppression
Intraocular pressure

This randomized clinical trial found that early intravitreal triamcinolone acetonide (TA) injection after open globe injury (OGI) effectively reduced traumatic proliferative vitreoretinopathy (TPVR), increased surgical success, and improved visual prognosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Intrapericardial treatment of autoreactive pericardial effusion with triamcinolone; the way to avoid side effects of systemic corticosteroid therapy.

Author: MaischB, RistićA D, PankuweitS

Pericarditis treatment effective
Cushing syndrome

Intrapericardial treatment with 300 mg x m(-2) x 24 h(-1) of triamcinolone prevented recurrence of symptoms and relapse of effusion in autoreactive pericarditis as effectively as the 600 mg x m(-2) x 24 h(-1) regimen, but with significantly fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Efficacy and safety of topical 0.1% cannabidiol for managing recurrent aphthous ulcers: a randomized controlled trial.

Author: UmpreechaChalapinyo, BhalangKanokporn, CharnvanichDusadee, LuckanagulJittima

Candidiasis prevention
RAU management

Topical steroids are a common treatment for recurrent aphthous ulcers (RAUs), but long-term use can cause candidiasis. Cannabidiol (CBD) has potential as an alternative treatment due to its analgesic and anti-inflammatory effects. This study evaluated the safety and efficacy of topical CBD for managing RAUs.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

A comparison of intralesional verapamil and triamcinolone monotherapy in the treatment of keloids in an African population.

Author: BelieO, UgburoA O, MofikoyaB O, T OmidijiO A, BelieM F

Keloid reduction

Verapamil as monotherapy is less effective than triamcinolone in resolving symptoms of keloids but is comparable in reducing the size of small-sized keloids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.