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Pregnancy outcomes after first-trimester treatment with artemisinin derivatives versus non-artemisinin antimalarials: a systematic review and individual patient data meta-analysis.

Author: AugustoOrvalho, ByamugishaJosaphat, ClerkChristine, DellicourStephanie, DesaiMeghna, GomesMelba, GuérinPhilippe J, HillJenny, KagawaMike, KariukiSimon, KisinzaWilliam, ManyandoChristine, McGreadyRose, MehtaUshma, MoshaDominic, MremaSigilbert, NjunjuEric M, NostenFrancois, RouambaToussaint, RulisaStephen, SaitoMakoto, SeveneEsperanca, SinglovicJan, StepniewskaKasia, StergachisAndy, Ter KuileFeiko O, TintoHalidou, ValaAnifa, WereEdwin, YoreMackensie, van EijkAnna Maria

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared adverse pregnancy outcomes after artemisinin-based treatment versus non-artemisinin-based treatments for malaria in the first trimester of pregnancy.
Paper Details　
Original Abstract of the Article :
Malaria in the first trimester of pregnancy is associated with adverse pregnancy outcomes. Artemisinin-based combination therapies (ACTs) are a highly effective, first-line treatment for uncomplicated Plasmodium falciparum malaria, except in the first trimester of pregnancy, when quinine with clinda...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9874756/

データ提供：米国国立医学図書館（NLM）

Pregnancy Outcomes and First-Trimester Artemisinin Treatment: A Comprehensive Analysis

The world of pregnancy is a delicate and complex one, with a myriad of factors influencing maternal and fetal health. Malaria, a serious infectious disease, poses a significant threat to pregnant women, particularly in the first trimester.

This study examines the impact of first-trimester treatment with artemisinin derivatives versus non-artemisinin antimalarials on pregnancy outcomes. Artemisinin-based combination therapies (ACTs) are highly effective for treating malaria, but concerns about potential embryotoxicity have led to recommendations against their use in the first trimester.

The study seeks to compare the safety and efficacy of artemisinin-based treatment (ABT) versus non-ABTs for first-trimester malaria, providing valuable insights into the optimal treatment strategy for pregnant women during this critical period.

Balancing Safety and Efficacy: A Careful Approach to Malaria Treatment in Pregnancy

This study highlights the challenges of balancing safety and efficacy in malaria treatment during pregnancy, particularly in the first trimester. The study underscores the need for a careful and individualized approach, considering the potential risks and benefits of different treatment options.

Navigating the Delicate Landscape of Pregnancy: A Journey Through the Desert of Maternal Health

This research provides a comprehensive analysis of the impact of artemisinin-based treatment on pregnancy outcomes. Like a camel carefully navigating the delicate landscape of pregnancy, we must approach malaria treatment with a nuanced understanding of the potential risks and benefits of different interventions.

Dr.Camel's Conclusion

This research underscores the importance of careful consideration when choosing malaria treatment options for pregnant women, particularly in the first trimester. Like a wise camel navigating the vast and often treacherous desert of maternal health, we must remain vigilant in our pursuit of safe and effective treatment strategies for pregnant women.

Date :
  1. Date Completed 2023-01-17
  2. Date Revised 2023-08-16
Further Info :

Pubmed ID

36442488

DOI: Digital Object Identifier

PMC9874756

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Languages

English

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