Evaluation the efficacy and safety of N-acetylcysteine inhalation spray in controlling the symptoms of patients with COVID-19: An open-label randomized controlled clinical trial.

Author: AtkinStephen L, GhaneiMostafa, PanahiYunes, RahimiMorteza, SahebkarAmirhossein, SamimAbbas, Vahedian-AzimiAmir

Paper Details 
Original Abstract of the Article :
The aim of this study was to evaluate the effect and safety of N-acetylcysteine (NAC) inhalation spray in the treatment of patients with coronavirus disease 2019 (COVID-19). This randomized controlled clinical trial study was conducted on patients with COVID-19. Eligible patients (n = 250) were rand...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878233/

データ提供:米国国立医学図書館(NLM)

N-Acetylcysteine Inhalation Spray for COVID-19: An Open-Label Randomized Controlled Clinical Trial

This open-label randomized controlled clinical trial evaluates the efficacy and safety of [N-acetylcysteine (NAC) inhalation spray] in treating [patients with COVID-19]. The study aims to assess the impact of NAC inhalation on [clinical features, hemodynamic parameters, hematological markers, biochemical indicators, and patient outcomes].

NAC Shows Potential in Reducing Mortality and Inflammation in COVID-19

The study, which included [250 patients with COVID-19], found that [NAC inhalation was associated with a significantly lower mortality rate compared to routine treatment alone]. Additionally, [NAC inhalation led to a significant reduction in inflammatory markers, such as white blood cell count, hemoglobin, C-reactive protein, and aspartate aminotransferase]. However, [NAC inhalation did not significantly affect hospital length of stay or the need for intensive care unit admission].

NAC as a Potential Adjunctive Therapy for COVID-19

The study suggests that [NAC inhalation may have a role as an adjunctive therapy for COVID-19]. While further research is needed to confirm these findings, the study provides promising evidence for NAC's potential to reduce mortality and inflammation in COVID-19 patients. However, it is crucial to note that [NAC did not impact hospital length of stay or the need for intensive care]. Further research is needed to clarify the specific benefits and optimal use of NAC in COVID-19 management.

Dr.Camel's Conclusion

This study provides important insights into the potential benefits of NAC inhalation for COVID-19 patients. It is like discovering a hidden oasis in a vast desert, offering a potential solution to a serious health challenge. While further research is needed, the findings suggest that NAC may play a role in improving outcomes for COVID-19 patients. The study underscores the importance of continued research to develop effective treatments for this complex disease.

Date :
  1. Date Completed 2023-02-01
  2. Date Revised 2023-02-09
Further Info :

Pubmed ID

36495185

DOI: Digital Object Identifier

PMC9878233

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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