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Combination treatment with varenicline and naltrexone reduces World Health Organization risk drinking levels.

Author: EndersCraig K, NietoSteven J, O'MalleyStephanie S, RayLara A, WitkiewitzKatie

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

While complete abstinence is the main goal of alcohol use disorder (AUD) treatments, many people struggle to achieve this, potentially discouraging them from seeking help. This study tested the use of World Health Organization (WHO) risk drinking levels as a possible treatment outcome for AUD medication trials. The researchers also explored the effectiveness of combining varenicline (a medication for smoking cessation) and naltrexone (a medication for AUD) in a clinical trial, providing further evidence on the potential of this combination approach.
Paper Details　
Original Abstract of the Article :
The U.S. Food and Drug Administration identifies abstinence and the absence of heavy drinking days as outcomes for pharmacotherapy trials for alcohol use disorder (AUD). However, many individuals with AUD struggle to achieve these outcomes, which may discourage them from seeking treatment. World Hea...See full text at original site
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引用元：
https://doi.org/10.1111/acer.14953

データ提供：米国国立医学図書館（NLM）

Combination Treatment with Varenicline and Naltrexone for Alcohol Use Disorder

This research delves into the challenging realm of [alcohol use disorder (AUD)] and explores the potential of [combination pharmacotherapy] as a treatment strategy. The study examines the effects of combining varenicline, a medication approved for smoking cessation, and naltrexone, a medication approved for AUD, in reducing alcohol consumption. The authors investigated the effectiveness of this combination therapy in reducing alcohol consumption to World Health Organization (WHO) risk drinking levels.

A New Approach to Reducing Alcohol Consumption

This research suggests that combining varenicline and naltrexone may hold promise as a treatment approach for reducing alcohol consumption to WHO risk drinking levels. The study's findings indicate that this combination therapy may be effective for individuals with AUD who struggle to achieve complete abstinence or significant reductions in heavy drinking days.

Seeking Support and Making Informed Choices

If you're struggling with AUD, it's important to seek support from qualified healthcare professionals. This study highlights the potential of combination pharmacotherapy as a treatment approach, but it's crucial to consult with your doctor to determine the most appropriate treatment plan for your individual needs. There are a variety of treatment options available, and working with your healthcare provider can help you make informed choices about the path that best aligns with your goals.

Dr. Camel's Conclusion

This research offers a hopeful sign for individuals struggling with AUD, suggesting that combination pharmacotherapy may provide a valuable tool for reducing alcohol consumption. The study's findings encourage further exploration of this approach and its potential to improve outcomes for those battling alcohol addiction. Remember, the desert of addiction can be a difficult place to navigate, but with the right support and guidance, recovery is possible. It's a journey that requires patience, determination, and a belief in the possibility of change.

Date :
  1. Date Completed 2022-12-20
  2. Date Revised 2023-01-30
Further Info :

Pubmed ID

36515648

DOI: Digital Object Identifier

10.1111/acer.14953

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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