Single dose letrozole and misoprostol for termination of pregnancy through 63 days' gestation: A pilot study.

Author: FryeLaura J, GawronLori M, KaiserJennifer E, SexsmithCorinne D, ShochetTara, TurokDavid, WinikoffBeverly

Paper Details 
Original Abstract of the Article :
We conducted a pilot study to evaluate a single dose of letrozole 30 mg prior to misoprostol 800 mcg buccally for medication abortion STUDY DESIGN: We enrolled 40 participants seeking medication abortion up to 63 days' gestation at a site in Salt Lake City, UT. Participants received a single dose of...See full text at original site
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引用元:
https://doi.org/10.1016/j.contraception.2022.109924

データ提供:米国国立医学図書館(NLM)

A Novel Medication Abortion Regimen: A Pilot Study

This pilot study explores a new approach to medication abortion using a single dose of letrozole followed by misoprostol. The research investigates the efficacy and safety of this regimen, analyzing the abortion outcomes and side effects in a small group of participants seeking medication abortion up to 63 days' gestation. The study's findings offer valuable insights into the potential of this approach for medication abortion.

A Single Dose Letrozole Regimen: Limited Efficacy in Medication Abortion

While the study's results demonstrate a potential for the regimen, the overall efficacy was lower than desired. Only 74% of participants experienced a complete abortion, with 10% experiencing an incomplete abortion and 15% having an ongoing pregnancy. These results suggest that the regimen requires further refinement to improve its effectiveness.

A Single Dose Letrozole Regimen: Considerations for Safety and Side Effects

The study reports a high incidence of side effects following misoprostol, which is consistent with previous research. However, the study also highlights a significant number of participants (51%) experiencing side effects after letrozole prior to misoprostol, with 5% rating these effects as severe. This highlights the need for further investigation into the potential side effects of letrozole in this context.

Dr.Camel's Conclusion

This pilot study is like a camel caravan setting out on a new path through the desert of medication abortion. While the new regimen shows potential, it's important to acknowledge that it still needs further exploration and improvement. The research highlights the need for more research to optimize the efficacy and safety of this approach. Let's keep trekking through the desert of medical knowledge to find the best solutions for women's healthcare.

Date :
  1. Date Completed 2023-03-07
  2. Date Revised 2023-04-14
Further Info :

Pubmed ID

36529240

DOI: Digital Object Identifier

10.1016/j.contraception.2022.109924

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SNS
PICO Info
in preparation
Languages

English

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