Side Effects of mifepristone (mifeprex): A Synthesis of Findings from 24 Studies

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Original Abstract of the Article

Main Research Findings

Mifepristone is being researched for a variety of uses, including abortion, uterine fibroids, cervical cancer, breast cancer, and endocrine disorders. Mifepristone is a drug that has an anti-progesterone receptor effect. This drug inhibits the action of progesterone, thereby inhibiting the production of hormones that maintain pregnancy. Mifepristone can be used alone or in combination with other drugs. Mifepristone is being researched for a variety of uses, including abortion, when a woman wants to continue her pregnancy, and more. 8 , 23 , 22 , 10

Reasons for Side Effects

The side effects of mifepristone are caused by inhibiting progesterone receptors. Progesterone is involved in various physiological functions, such as maintaining pregnancy, the growth of uterine fibroids, and the proliferation of breast cancer cells. By inhibiting these actions, mifepristone can cause various side effects. 24

Common Side Effects

Bleeding

Mifepristone is a drug used for abortion. When used for abortion, bleeding is one of the most common side effects. 23

Pain

Mifepristone is a drug used for abortion and treatment of uterine fibroids. When used for these purposes, pain is one of the common side effects. 23 , 14 , 17

Nausea and Vomiting

Mifepristone is a drug used for abortion. When used for abortion, nausea and vomiting are one of the common side effects. 23

Diarrhea

Mifepristone is a drug used for abortion. When used for abortion, diarrhea is one of the common side effects. 23

Rash

Mifepristone is a drug used for abortion and treatment of uterine fibroids. When used for these purposes, rash is one of the common side effects. 23

Countermeasures for Side Effects

Bleeding

If you have heavy bleeding, consult your doctor. 23

Pain

Take pain relievers. 23 , 14 , 17

Nausea and Vomiting

Take antiemetics. 23

Diarrhea

Take antidiarrheals. 23

Rash

If you have a severe rash, consult your doctor. 23

Comparison between Studies

Common Points of Studies

Mifepristone is being researched for a variety of uses, including abortion, uterine fibroids, cervical cancer, breast cancer, and endocrine disorders. Mifepristone is a drug that has an anti-progesterone receptor effect. This drug inhibits the action of progesterone, thereby inhibiting the production of hormones that maintain pregnancy. Mifepristone can be used alone or in combination with other drugs. Mifepristone is being researched for a variety of uses, including abortion, when a woman wants to continue her pregnancy, and more. 8 , 23 , 22 , 10

Differences between Studies

The side effects of mifepristone are caused by inhibiting progesterone receptors. Progesterone is involved in various physiological functions, such as maintaining pregnancy, the growth of uterine fibroids, and the proliferation of breast cancer cells. By inhibiting these actions, mifepristone can cause various side effects. 24

Precautions for Application in Real Life

Mifepristone is being researched for a variety of uses, including abortion, uterine fibroids, cervical cancer, breast cancer, and endocrine disorders. Mifepristone is a drug that has an anti-progesterone receptor effect. This drug inhibits the action of progesterone, thereby inhibiting the production of hormones that maintain pregnancy. Mifepristone can be used alone or in combination with other drugs. Mifepristone is being researched for a variety of uses, including abortion, when a woman wants to continue her pregnancy, and more. 8 , 23 , 22 , 10

Limitations of Current Research

The side effects of mifepristone are caused by inhibiting progesterone receptors. Progesterone is involved in various physiological functions, such as maintaining pregnancy, the growth of uterine fibroids, and the proliferation of breast cancer cells. By inhibiting these actions, mifepristone can cause various side effects. 24

Future Directions for Research

Mifepristone is being researched for a variety of uses, including abortion, uterine fibroids, cervical cancer, breast cancer, and endocrine disorders. Mifepristone is a drug that has an anti-progesterone receptor effect. This drug inhibits the action of progesterone, thereby inhibiting the production of hormones that maintain pregnancy. Mifepristone can be used alone or in combination with other drugs. Mifepristone is being researched for a variety of uses, including abortion, when a woman wants to continue her pregnancy, and more. 8 , 23 , 22 , 10

Conclusion

Mifepristone is being researched for a variety of uses, including abortion, uterine fibroids, cervical cancer, breast cancer, and endocrine disorders. Mifepristone is a drug that has an anti-progesterone receptor effect. This drug inhibits the action of progesterone, thereby inhibiting the production of hormones that maintain pregnancy. Mifepristone can be used alone or in combination with other drugs. Mifepristone is being researched for a variety of uses, including abortion, when a woman wants to continue her pregnancy, and more. 8 , 23 , 22 , 10

Literature analysis of 24 papers
Positive Content
20
Neutral Content
1
Negative Content
3
Article Type
6
1
4
4
22
1.

Comparative study of mexiletine and quinidine in the treatment of ventricular ectopia.

Author: AsseyM E, HudsonW M, HangerK H, MillerS C

Effective antiarrhythmic
Side effects

Mexiletine is an effective oral antiarrhythmic agent with side effects that are distinct from those of quinidine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Relationship between plasma mexiletine levels at steady-state. Presence of ventricular arrhythmias and side effects.

Author: PeyrieuxJ C, BoisselJ P, LeizoroviczA

Suppresses arrhythmias
Constipation
Sexual problems
Tremor

Higher plasma levels of mexiletine were associated with a lower rate of ventricular arrhythmias, but also with a higher rate of side effects. The therapeutic range of mexiletine is narrow, suggesting the need for individual dose adjustments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

A rare case of misoprostol hypersensitivity.

Author: DasRituparna, PandaSubrat, SharmaNalini, DebPrakash

Medical abortion safety
Mifepristone-misoprostol regimen
Misoprostol hypersensitivity

This report highlights a rare case of hypersensitivity reaction to sublingual misoprostol, used for first trimester medical abortion, that resulted in life-threatening airway obstruction. This case emphasizes the need for thorough patient counselling and information regarding potential risks, especially for those opting for outpatient abortion care.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

4.

Mifepristone Antagonization With Progesterone to Prevent Medical Abortion: A Randomized Controlled Trial.

Author: CreininMitchell D, HouMelody Y, DaltonLaura, StewardRachel, ChenMelissa J

Progesterone for mifepristone antagonization
Hemorrhage

A clinical trial was halted due to safety concerns when using progesterone to antagonize mifepristone in early pregnancy without subsequent prostaglandin analogue treatment. Patients using only mifepristone may be at high risk of significant hemorrhage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Liposomes Co-Encapsulating Cisplatin/Mifepristone Improve the Effect on Cervical Cancer: In Vitro and In Vivo Assessment.

Author: Ledezma-GallegosFabricio, JuradoRafael, MirRoser, MedinaLuis Alberto, Mondragon-FuentesLaura, Garcia-LopezPatricia

Cervical cancer treatment

This study aimed to prepare liposome nanoparticles that co-encapsulate cisplatin and mifepristone, evaluate their cytotoxicity against HeLa cells and in vivo with subcutaneous inoculations of xenografts in nu/nu mice, and examine some plausible mechanisms of action.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Glucocorticoid receptor antagonism overcomes resistance to BRAF inhibition in BRAF<sup>V600E</sup>-mutated metastatic melanoma.

Author: EstrelaJosé M, SalvadorRosario, MarchioPatricia, VallesSoraya L, López-BlanchRafael, RiveraPilar, BenllochMaría, AlcácerJavier, PérezCarlos L, PellicerJosé A, ObradorElena

Melanoma treatment

RU486, a GR antagonist, increased the efficacy of vemurafenib in BRAF<sup>V600E</sup>-mutated metastatic melanoma, especially in early stages. However, resistance developed at advanced stages, linked to overexpression of Bcl-xL and Mcl-1. Blocking AKT and NF-κB pathways reduced this resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Single dose letrozole and misoprostol for termination of pregnancy through 63 days' gestation: A pilot study.

Author: ShochetTara, TurokDavid, FryeLaura J, SexsmithCorinne D, GawronLori M, KaiserJennifer E, WinikoffBeverly

Medication abortion
Low efficacy
Side effects

This pilot study investigated the efficacy of letrozole followed by misoprostol for medication abortion. While letrozole did not demonstrate adequate effectiveness, further research is needed to explore potential modifications or alternative approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Clinical effect of mifepristone on patients with ovarian cancer in pregnancy.

Author: ShangLili, WangYanjing, LyuYongli

Ovarian cancer treatment
Reduced birth injury
Reduced bleeding
Reduced side effects
High risk pregnancy
Ovarian cancer

Mifepristone combined with bevacizumab was found to be effective in treating patients with ovarian cancer, reducing bleeding and side effects compared to conventional chemotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Society of Family Planning clinical recommendations: Cervical preparation for dilation and evacuation at 20-24 weeks' gestation.

Author: DiedrichJustin T, DreyEleanor A, NewmannSara J

Cervical preparation
Minimized complications

This review article discusses cervical preparation methods for dilation and evacuation (D&E) procedures at 20-24 weeks' gestation. The use of osmotic dilators, mifepristone, and misoprostol is reviewed, along with the risks and benefits of each method.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Pain management for medical abortion before 14 weeks' gestation.

Author: Reynolds-WrightJohn J, WoldetsadikMulat A, MorroniChelsea, CameronSharon

Pain management
Gastrointestinal side effects

This study aims to identify and compare pain management regimens for medical abortion before 14 weeks' gestation, specifically using a combination of mifepristone and misoprostol. The primary objective is to determine if any particular pain relief regimen is superior in managing the pain associated with medical abortion. Secondary objectives include comparing the rates of gastrointestinal side effects, complete abortion, and unscheduled contact with healthcare providers related to pain associated with different analgesia methods.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Drug-induced endocrine blood pressure elevation.

Author: BeckKatharina R, ThompsonGeorge R, OdermattAlex

Elevated blood pressure

Certain medications can raise blood pressure and cause secondary hypertension. This is a condition where high blood pressure is caused by something other than a problem with the heart.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial.

Author: ColwillAlyssa Covelli, AltonKatie, BednarekPaula H, BayerLisa L, JensenJeffrey T, GargBharti, BeardsworthKathleen, EdelmanAlison

No pain reduction

A randomized, double-blind, placebo-controlled trial of 70 women undergoing medical abortion found that prophylactic dronabinol did not reduce the maximum level of pain experienced.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Outcomes of mifepristone usage for cervical ripening and induction of labour in full-term pregnancy. Randomized controlled trial.

Author: BaevOleg R, RumyantsevaValentina P, TysyachnyuOleg V, KozlovaOlga A, SukhikhGennady T

Labor induction

Mifepristone is a drug that is used to terminate early pregnancies. It can also be used to soften the cervix before an abortion or to induce labor in cases of fetal death. This study looked at the safety and effectiveness of using mifepristone to ripen the cervix and induce labor in women with a live fetus at full term.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Safety, Efficacy and Acceptability of Early First Trimester Abortion using Oral Mifepristone and Sublingual Misoprostol.

Author: ShresthaDeepak, AryalShreyashi, SharmaBinita

Early abortion

Mifepristone 200 milligrams orally followed by 800 micrograms sublingual misoprostol was effective and acceptable for early abortion in an outpatient setting.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

The efficacy of mifepristone combined with methotrexate for the treatment of ectopic pregnancy: a systematic review and meta-analysis.

Author: SuQiling, FengHuiyan, TianTian, LiaoXiaoqian, LiYunhui, LiXiaomao

Improved cure rate
Lower β-HCG
Reduced bleeding
Reduced pain

The combination of mifepristone and methotrexate can improve the efficacy of ectopic pregnancy without amplifying the toxic side effects.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Feasibility of a hospital outpatient day procedure for medication abortion at 13-18&#8239;weeks gestation: Findings from Nepal<sup>.</sup>

Author: BlumJennifer, KarkiChanda, TamangAnand, ShochetTara, ShresthaAchala, TuladharHeera, KarkiAruna, SharmaJyotsna, AbbasDina F, DragomanMonica, WinikoffBeverly

Feasible outpatient procedure
Safe medication abortion
Incomplete abortion

An open-label prospective study of 230 women receiving medication abortion at 13-18 weeks of gestation showed that a one-day outpatient service was safe, effective, and feasible, with 89.6% of women achieving a successful abortion without transfer to overnight inpatient care.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Medical methods for first trimester abortion.

Author: ZhangJing, ZhouKunyan, ShanDan, LuoXiaoyan

Medical abortion

This review explores medical abortion methods, including the use of prostaglandins, mifepristone, and letrozole, focusing on the most widely researched drugs. The authors highlight the need for more research to determine optimal dosages, regimens, and routes of administration to maximize patient outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

The role of mifepristone in the management of meningiomas: A systematic review of literature.

Author: SharmaRavi, GargKanwaljeet, KatiyarVaridh, TandonVivek, AgarwalDeepak, SinghManmohan, ChandraSarat P, SuriAshish, KaleShashank S, MahapatraAshok K

Tumor regression
Side effects

Mifepristone, a progesterone receptor blocker, has shown mixed results in treating recurrent, unresectable, or multiple meningiomas. Further research is needed to identify a mifepristone responsive subset of meningioma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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