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Antipsychotics in the Treatment of Children and Adolescents with Anorexia Nervosa: A Systematic Review.

Author: BergonziniLuca, La TempaAngela, ParmeggianiAntonia, PruccoliJacopo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

The use of antipsychotics in treating Anorexia Nervosa (AN) in children and adolescents remains understudied. A systematic scoping review suggests that antipsychotics, particularly olanzapine, may offer benefits in terms of psychopathology and weight gain, but further research with robust methodologies is crucial to confirm their efficacy and safety in this population.
Paper Details　
Original Abstract of the Article :
Evidence about the use of pharmacologic agents in the treatment of Anorexia Nervosa (AN) is lacking, especially in childhood and adolescence. A systematic scoping review was conducted to outline current literature evidence about the use of antipsychotics in this population. A total of 499 studies we...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775317/

データ提供：米国国立医学図書館（NLM）

Antipsychotics in the Treatment of Anorexia Nervosa: A Scoping Review

This scoping review systematically evaluates the current literature on the use of antipsychotics in the treatment of Anorexia Nervosa (AN) in children and adolescents. The authors conducted a comprehensive search of relevant studies, focusing on the use of olanzapine, risperidone, aripiprazole, chlorpromazine, pimozide, clotiapine, and multiple antipsychotics in young patients with AN. The review aims to provide an overview of the evidence base for antipsychotic use in this population.

Limited Evidence but Potential Benefits

The review found limited evidence to support the use of antipsychotics in children and adolescents with AN. The majority of studies included in the review were observational studies, with a lack of robust randomized controlled trials. While some studies suggested improvements in psychopathology and weight measures, the lack of high-quality evidence limits the generalizability of these findings to clinical practice.

Need for Further Research

This scoping review highlights the urgent need for rigorous research into the use of antipsychotics in the treatment of AN in children and adolescents. The authors call for well-designed randomized controlled trials to provide more conclusive evidence regarding the efficacy and safety of these medications in this population. Further research is necessary to inform clinical decision-making and ensure that young patients with AN receive the most appropriate and effective treatment.

Dr. Camel's Conclusion

This research is like a compass guiding us through the intricate landscape of AN treatment. The authors point out the lack of definitive evidence regarding the use of antipsychotics in young patients with AN, highlighting the need for further research. This review underscores the importance of evidence-based practice and the pursuit of robust research to ensure the best possible outcomes for individuals with this complex eating disorder.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-12-25
Further Info :

Pubmed ID

36551922

DOI: Digital Object Identifier

PMC9775317

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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