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Stability of Non-Ionic Surfactant Vesicles Loaded with Rifamycin S.

Author: Blanco-LópezMaria Carmen, CabalMaria Paz, GutiérrezGemma, MarcetIsmael, MarchianòVerdiana, MatosMaria

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Niosomes, non-ionic vesicles, offer a promising drug delivery system for enhancing the efficacy and reducing the side effects of antibiotics. This study investigated the encapsulation of Rifamycin S, a potent antibiotic, into niosomes for the treatment of Staphylococcus aureus infection. Niosomes prepared with an aqueous glycerol solution demonstrated higher stability, encapsulation efficiency, and lower minimum inhibitory concentration (MIC) against S. aureus compared to other formulations.
Paper Details　
Original Abstract of the Article :
These days, the eradication of bacterial infections is more difficult due to the mechanism of resistance that bacteria have developed towards traditional antibiotics. One of the medical strategies used against bacteria is the therapy with drug delivery systems. Non-ionic vesicles are nanomaterials w...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785864/

データ提供：米国国立医学図書館（NLM）

Stability of Non-Ionic Surfactant Vesicles Loaded with Rifamycin S

This research investigates the potential of non-ionic surfactant vesicles (niosomes) as a drug delivery system for the antibiotic rifamycin S. The researchers prepared niosomes loaded with rifamycin S using different formulations and evaluated their stability under various conditions, including different temperatures and pH values. They also assessed the antimicrobial activity of rifamycin S encapsulated in niosomes against Staphylococcus aureus. The findings suggest that niosomes can provide a stable and effective delivery system for rifamycin S, potentially enhancing its therapeutic efficacy.

Niosomes for Rifamycin S Delivery

The study found that niosomes prepared with glycerol in the aqueous phase demonstrated superior stability and encapsulation efficiency compared to other formulations. Furthermore, the study showed that rifamycin S encapsulated in niosomes exhibited enhanced antimicrobial activity against S. aureus, suggesting that niosomes can improve the delivery and effectiveness of rifamycin S.

Antibiotic Delivery and Drug Resistance

The study highlights the potential of nanotechnology for improving antibiotic delivery and potentially mitigating the growing problem of drug resistance. Niosomes, as a stable and effective drug delivery system, could play a significant role in enhancing the efficacy of existing antibiotics and combating bacterial infections.

Dr.Camel's Conclusion

Imagine a camel caravan carrying precious water across a parched desert. Niosomes are like sturdy water containers that protect the precious liquid from the harsh desert environment. Rifamycin S, like the water itself, is essential for combating the desert's harmful bacteria. This research suggests that niosomes can effectively protect and deliver rifamycin S, ensuring its journey to its destination and its ability to fight bacterial infections.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-12-27
Further Info :

Pubmed ID

36559121

DOI: Digital Object Identifier

PMC9785864

Related Literature

Article Analysis
・Side Effects of rifamycin
SNS
PICO Info
in preparation
Languages

English

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