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Stereotactic ablative radiotherapy or best supportive care in patients with localized pancreatic cancer not receiving chemotherapy and surgery (PANCOSAR): a nationwide multicenter randomized controlled trial according to a TwiCs design.

Author: , BesselinkM G, BruynzeelA M E, DoppenbergD, IntvenM P W, KazemierG, KoerkampB Groot, LagerwaardF J, MeijerinkM, MolenaarI Q, NuyttensJ J M E, VerkooijenH M, VersteijneE, WilminkJ W, van EijckC H J, van LaarhovenH W M, van OsR, van SantvoortH C, van TienhovenG

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study explores the potential of stereotactic ablative body radiotherapy (SABR) as a treatment option for patients with localized pancreatic ductal adenocarcinoma (PDAC) who are not candidates for surgery or systemic therapy. Current treatment options for these patients are limited to best supportive care.
Paper Details　
Original Abstract of the Article :
Significant comorbidities, advanced age, and a poor performance status prevent surgery and systemic treatment for many patients with localized (non-metastatic) pancreatic ductal adenocarcinoma (PDAC). These patients are currently treated with 'best supportive care'. Therefore, it is desirable to fin...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9801528/

データ提供：米国国立医学図書館（NLM）

Stereotactic Ablative Radiotherapy: A Potential Oasis in the Desert of Localized Pancreatic Cancer

Pancreatic cancer is a challenging disease, and finding effective treatment options for patients who are not eligible for surgery or chemotherapy can be difficult. This nationwide multicenter randomized controlled trial investigates the potential of stereotactic ablative radiotherapy (SABR) as a treatment option for patients with localized pancreatic cancer who are not receiving chemotherapy and surgery. The researchers sought to evaluate the effectiveness of SABR in improving disease control and quality of life.

SABR: A Potential Option for Localized Pancreatic Cancer

The study, designed as a TwiCs (two-arm, two-stage, single-center) trial, is ongoing and aims to assess the impact of SABR compared to best supportive care. This research is like exploring a new path in the desert, seeking a more effective approach to treating this challenging disease. The results of this trial will be crucial in determining the role of SABR in the management of localized pancreatic cancer.

A New Path in Pancreatic Cancer Treatment

This research highlights the ongoing search for effective treatment options for pancreatic cancer. By exploring the potential of SABR, we can expand the treatment landscape and provide more options for patients who are not candidates for traditional therapies. This study represents a significant step towards improving the lives of individuals facing this difficult diagnosis.

Dr. Camel's Conclusion

The desert of pancreatic cancer treatment is vast and unforgiving, but this ongoing trial offers a beacon of hope. By exploring the potential of SABR, we can expand the treatment landscape and provide more options for patients. This research is a testament to the ongoing efforts to improve the lives of those affected by this challenging disease.

Date :
  1. Date Completed 2023-01-06
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

36581914

DOI: Digital Object Identifier

PMC9801528

Related Literature

Article Analysis
・Effective treatment of pancreatic cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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