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Preventing cardiotoxicity in patients with breast cancer and lymphoma: protocol for a multicentre randomised controlled trial (PROACT).

Author: AkhterNasima, AustinDavid, ChangLisa, CrestiNicola, GrahamJanine, GrahamRichard, HancockHelen C, HaneySophie, HumphreysAlison, KasimAdetayo S, MaddoxJamie, MaierRebecca H, OgundimuEmmanuel, OxenhamHelen, PlummerChris, StewartMichael, VahabiSharareh, VerrillMark, WardleyAndrew

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Anthracyclines, effective chemotherapy drugs, can cause cardiotoxicity leading to heart failure. The PROACT trial will evaluate the effectiveness of the ACE inhibitor enalapril in preventing cardiotoxicity in patients with breast cancer and non-Hodgkin's lymphoma receiving anthracycline-based chemotherapy.
Paper Details　
Original Abstract of the Article :
Anthracyclines are included in chemotherapy regimens to treat several different types of cancer and are extremely effective. However, it is recognised that a significant side effect is cardiotoxicity; anthracyclines can cause irreversible damage to cardiac cells and ultimately impaired cardiac funct...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809245/

データ提供：米国国立医学図書館（NLM）

Cardiotoxicity: A Desert Storm in Cancer Treatment

This research, like a valiant expedition navigating a desert filled with hidden dangers, focuses on the cardiotoxicity associated with anthracycline-based chemotherapy. The researchers, driven by a desire to protect patients from these adverse effects, propose a randomized controlled trial to evaluate the potential of enalapril, an ACE inhibitor, in preventing heart damage.

Protecting the Heart: A Desert Oasis for Cancer Patients

The study aims to establish the effectiveness of enalapril in preventing cardiotoxicity in patients with breast cancer and lymphoma. It's like finding a hidden oasis in the harsh desert of cancer treatment, offering a way to shield the heart from the damaging effects of chemotherapy. This research, like a ray of hope in the face of adversity, could significantly improve the quality of life for patients undergoing these challenging treatments.

A Balanced Approach: Navigating the Desert of Cancer Treatment

This research underscores the importance of a balanced approach to cancer treatment. While anthracyclines are powerful weapons against cancer, it's crucial to consider the potential side effects and develop strategies to mitigate them. This study, like a guidebook for travelers in the desert, encourages us to explore new pathways to protect patients from the harsh realities of cancer therapy.

Dr. Camel's Conclusion

This research, like a visionary roadmap through the desert of medical innovation, highlights the critical need for strategies to prevent cardiotoxicity in cancer treatment. The proposed trial could potentially pave the way for a safer and more effective approach to cancer therapy, offering a beacon of hope for patients facing this challenging disease. As we continue our journey, let's strive to develop innovative solutions that protect the health and well-being of those battling cancer.

Date :
  1. Date Completed 2023-01-03
  2. Date Revised 2023-01-11
Further Info :

Pubmed ID

36585130

DOI: Digital Object Identifier

PMC9809245

Related Literature

Article Analysis
・Side Effects of enalapril
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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