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A rare case report of iatrogenic Cushing syndrome caused by direct anti-hepatitis C virus therapy with sofosbuvir/velpatasvir.
Author: HanYujin, HuangJianjie, JinQinglong, MaBo, ShangTianling, TuZhixin, WangYan, WangYang, WenXiaoyu
Original Abstract of the Article :
Sofosbuvir/velpatasvir (SOF/VEL) is a combination of direct-acting antivirals with pan-genotypic activity that is used to treat chronic hepatitis C virus infection. This was a fixed-dose regimen. SOF is a nucleotide nonstructural 5B polymerase inhibitor and VEL is an nonstructural 5A inhibitor. Side...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794295/
データ提供:米国国立医学図書館(NLM)
A Rare Case of Iatrogenic Cushing Syndrome: The Unexpected Side Effects of Hepatitis C Treatment
Sofosbuvir/velpatasvir (SOF/VEL) is a combination of direct-acting antivirals used to treat chronic hepatitis C virus infection. While generally considered safe, rare side effects can occur. This case report, led by Dr. [Author's last name], investigated a unique instance of iatrogenic Cushing syndrome (ICS) caused by SOF/VEL therapy. The researchers explored the potential mechanisms behind this unusual side effect.
A Desert of Side Effects: Uncovering the Unexpected
The case report presents a rare occurrence of ICS, a condition characterized by excessive cortisol production, in a patient receiving SOF/VEL therapy. This finding highlights the importance of being aware of potential side effects, even those considered rare. It's like discovering a hidden oasis in the desert – unexpected and potentially impactful.
Navigating the Sands of Treatment Decisions:
This case underscores the need for careful monitoring of patients receiving SOF/VEL therapy, particularly those with pre-existing endocrine conditions. It emphasizes the importance of individualized treatment plans and ongoing assessment of potential side effects. It's a reminder that even in the face of effective treatment, we must remain vigilant and prepared for the unexpected.
Dr.Camel's Conclusion
This case report serves as a reminder that even with the most advanced medications, there can be unexpected side effects. It highlights the importance of continued research and vigilance in monitoring the effects of medications, even those considered safe and effective. It's a reminder that the journey through the desert of healthcare is full of unexpected twists and turns.
Date :
- Date Completed 2023-01-05
- Date Revised 2023-01-11
Further Info :
Related Literature
English
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