A rare case report of iatrogenic Cushing syndrome caused by direct anti-hepatitis C virus therapy with sofosbuvir/velpatasvir.

Author: HanYujin, HuangJianjie, JinQinglong, MaBo, ShangTianling, TuZhixin, WangYan, WangYang, WenXiaoyu

Paper Details 
Original Abstract of the Article :
Sofosbuvir/velpatasvir (SOF/VEL) is a combination of direct-acting antivirals with pan-genotypic activity that is used to treat chronic hepatitis C virus infection. This was a fixed-dose regimen. SOF is a nucleotide nonstructural 5B polymerase inhibitor and VEL is an nonstructural 5A inhibitor. Side...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794295/

データ提供:米国国立医学図書館(NLM)

A Rare Case of Iatrogenic Cushing Syndrome: The Unexpected Side Effects of Hepatitis C Treatment

Sofosbuvir/velpatasvir (SOF/VEL) is a combination of direct-acting antivirals used to treat chronic hepatitis C virus infection. While generally considered safe, rare side effects can occur. This case report, led by Dr. [Author's last name], investigated a unique instance of iatrogenic Cushing syndrome (ICS) caused by SOF/VEL therapy. The researchers explored the potential mechanisms behind this unusual side effect.

A Desert of Side Effects: Uncovering the Unexpected

The case report presents a rare occurrence of ICS, a condition characterized by excessive cortisol production, in a patient receiving SOF/VEL therapy. This finding highlights the importance of being aware of potential side effects, even those considered rare. It's like discovering a hidden oasis in the desert – unexpected and potentially impactful.

Navigating the Sands of Treatment Decisions:

This case underscores the need for careful monitoring of patients receiving SOF/VEL therapy, particularly those with pre-existing endocrine conditions. It emphasizes the importance of individualized treatment plans and ongoing assessment of potential side effects. It's a reminder that even in the face of effective treatment, we must remain vigilant and prepared for the unexpected.

Dr.Camel's Conclusion

This case report serves as a reminder that even with the most advanced medications, there can be unexpected side effects. It highlights the importance of continued research and vigilance in monitoring the effects of medications, even those considered safe and effective. It's a reminder that the journey through the desert of healthcare is full of unexpected twists and turns.

Date :
  1. Date Completed 2023-01-05
  2. Date Revised 2023-01-11
Further Info :

Pubmed ID

36595855

DOI: Digital Object Identifier

PMC9794295

SNS
PICO Info
in preparation
Languages

English

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