The core of maintaining neuropathic pain: Crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord).

Author: CuiShuang, GuoFanfan, JiaZhanhong, LiangWulin, OuWenjing, WuYonghong, ZhangMingqian, ZhangShuofeng, ZhangTianrui

Paper Details 
Original Abstract of the Article :
Neuropathic pain (NP) caused by the injury or dysfunction of the nervous system is a chronic pain state accompanied by hyperalgesia, and the available clinical treatment is relatively scarce. Hyperalgesia mediated by pro-inflammatory factors and chemokines plays an important role in the occurrence a...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927860/

データ提供:米国国立医学図書館(NLM)

Neuropathic Pain: The Glial-Neuronal Crossroads in the Desert of Chronic Pain

Neuropathic pain, a persistent and often excruciating storm that rages through the nervous system, remains a significant challenge in the medical desert. Researchers, like desert explorers navigating uncharted territories, are constantly seeking new understanding of this complex condition. This study delves into the intricate pathways of neuropathic pain, exploring the interactions between glial cells and neurons in the spinal cord. The researchers uncover the crucial role of pro-inflammatory factors and chemokines in the development and persistence of neuropathic pain. The study provides valuable insights into the underlying mechanisms of this condition, paving the way for more effective treatment strategies.

Navigating the Desert of Chronic Pain

The study highlights the critical role of glial-neuronal crosstalk in maintaining neuropathic pain. The findings underscore the importance of inflammatory mediators in the perpetuation of this chronic condition. This understanding paves the way for the development of targeted therapies that interrupt these inflammatory pathways, potentially offering a more effective approach to managing neuropathic pain.

Oasis of Targeted Therapy

This study sheds light on the complex pathways involved in neuropathic pain, revealing the key role of glial-neuronal interactions and inflammatory mediators. It emphasizes the need for targeted therapies that address these specific mechanisms, potentially providing a more effective approach to mitigating the intense and persistent storm of chronic pain.

Dr.Camel's Conclusion

This study suggests that understanding the intricate crosstalk between glial cells and neurons in the desert of chronic pain is crucial for developing more effective treatments for neuropathic pain. By targeting the inflammatory pathways responsible for pain maintenance, researchers hope to create a more effective oasis of relief for those suffering from this debilitating condition.

Date :
  1. Date Completed 2023-02-16
  2. Date Revised 2023-02-28
Further Info :

Pubmed ID

36602945

DOI: Digital Object Identifier

PMC9927860

Related Literature

SNS
PICO Info
in preparation
Languages

English

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