Effective treatment of chronic pain: A Synthesis of Findings from 56 Studies

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Original Abstract of the Article

Key Research Findings

Research on chronic pain treatment has explored a variety of approaches, yielding promising results. For example, 47 reported that a single-session Zoom-delivered group intervention called "Empowered Relief" was effective in reducing chronic pain. Additionally, 45 suggested that a combination of hypnosis and transcutaneous electrical nerve stimulation (TENS) might be effective in alleviating chronic non-cancer pain.

Furthermore, 13 indicated that collaborative care for patients with comorbid pain and depression could improve their quality of life. These studies offer valuable insights that contribute to the development of effective treatments for chronic pain.

Treatment Summary

47 reported that a single-session Zoom-delivered group intervention called "Empowered Relief" was effective in reducing chronic pain. This approach offers greater convenience for patients compared to traditional therapies, as they can participate from home.

45 suggested that a combination of hypnosis and transcutaneous electrical nerve stimulation (TENS) might be effective in alleviating chronic non-cancer pain. This treatment aims to reduce pain by integrating both physical and mental approaches.

13 indicated that collaborative care for patients with comorbid pain and depression could improve their quality of life. This approach emphasizes coordinated efforts among various specialists to deliver the most appropriate care for each patient.

Benefits and Risks

Benefits Summary

Chronic pain treatment methods have the potential to enhance patients' quality of life. For example, 47 reported that a single-session Zoom-delivered group intervention called "Empowered Relief" was effective in reducing chronic pain. This approach offers greater convenience for patients compared to traditional therapies, as they can participate from home. Additionally, 45 suggested that a combination of hypnosis and transcutaneous electrical nerve stimulation (TENS) might be effective in alleviating chronic non-cancer pain. This treatment aims to reduce pain by integrating both physical and mental approaches.

Risks Summary

Chronic pain treatment methods can have side effects and risks. For instance, 30 expressed concerns about side effects associated with cannabis-based medications for chronic neuropathic pain. Additionally, 50 pointed out that patients undergoing opioid reduction for chronic pain may face risks of worsening symptoms. Therefore, careful consultation with a physician is crucial when choosing chronic pain treatment methods.

Comparison Across Studies

Commonalities

These studies share a common goal: to identify effective treatments for chronic pain. Numerous studies have explored various approaches, including medication, psychotherapy, and physical therapy. Moreover, these studies recognize the significant impact of chronic pain on patients' quality of life.

Differences

These studies vary in their target pain types, treatments, and research designs. For instance, 47 examined the effectiveness of a Zoom-delivered group intervention, while 45 investigated the efficacy of a combination of hypnosis and transcutaneous electrical nerve stimulation (TENS). Furthermore, 13 focused on patients with comorbid pain and depression, distinguishing it from other studies with different participant populations.

Consistency and Inconsistencies in Results

These studies suggest that effective treatments for chronic pain exist, but their effectiveness may vary across individuals. Additionally, some therapies might carry side effects or risks. Therefore, it's crucial to consult with a physician when selecting a chronic pain treatment method.

Considerations for Real-World Application

When applying chronic pain treatment methods to everyday life, several precautions are essential. First, not every treatment works for all patients. Additionally, treatment methods can have side effects and risks. Therefore, consulting with a physician to choose an appropriate treatment is vital. Moreover, managing chronic pain often involves a combination of medication, psychotherapy, and physical therapy. Combining these approaches can potentially lead to more effective pain reduction.

Limitations of Current Research

Chronic pain research faces several limitations. For instance, the number of participants in some studies may be limited, and standardized methods for evaluating treatment effectiveness may not be fully established. Furthermore, chronic pain is a complex condition without universally shared causes or symptoms. Consequently, developing chronic pain treatments is challenging. However, recent advancements in chronic pain research offer hope for the development of more effective treatments.

Future Directions for Research

Future research on chronic pain should focus on developing more effective treatments, establishing standardized methods for evaluating treatment effectiveness, and elucidating the causes of chronic pain. Furthermore, active patient participation in treatment is critical. By understanding their symptoms and treatment methods and collaborating with physicians, patients can potentially achieve more effective pain reduction.

Conclusion

Research on chronic pain treatment has yielded numerous promising results. However, these studies have limitations and require further investigation. For those suffering from chronic pain, it is essential to consult with a physician to select an appropriate treatment that suits their individual needs.

Treatment List

  • Zoom-delivered group intervention "Empowered Relief"
  • Hypnosis
  • Transcutaneous Electrical Nerve Stimulation (TENS)
  • Collaborative care
  • Medication therapy
  • Psychotherapy
  • Physical therapy
Keywords
Benefit Keywords
Improved chronic pain treatment
1
Improve HRQL
Reduce pain intensity
2
Chronic low back pain relief
3
Treatment of chronic pain
4
Improved QOL
Improved QOS
Reduced pain episodes
5
Sleep improvement
6
Fatigue reduction
Improved mood
Pain reduction
Quality of life improvement
Sleep improvement
7
Chronic pain treatment
8
Chronic pain treatment
9
Improved sleep
Reduced pain
10
Improved pain treatment
11
Chronic pain treatment
12
Depression treatment
Pain management
13
Pain reduction
14
Trigger-point injection
tDCS
15
Pain reduction
16
Non-pharmacological interventions
17
Functional capacity
Pain reduction
18
Reduced pain interference
Reduced pain severity
Reduced pain-related disability
19
Neuropathic pain relief
20
Chronic pain treatment
21
Chronic pain treatment
22
Effective treatment
Improved pain
23
Chronic pain treatment
24
Improved functioning
Improved health
Reduced pain severity
26
Pain neuroscience education
27
Improved neuropathic pain
Pain relief
29
Reduced pain
30
Reduced pain impact
31
Improved chronic pain treatment
Improved sleep
32
Improved kinesiophobia
Reduced illness perception
Reduced pain catastrophizing
33
Improved self-efficacy
Reduced pain
34
Chronic pain treatment
TENS
35
Improved quality of life
Reduced depression
36
Improved chronic pain treatment
37
Reduced chronic pelvic pain
38
Chronic pain management
39
Chronic non-cancer pain treatment
40
Exercise for chronic pain
41
Jaw function
Occlusal splint effect
42
Chronic low back pain reduction
43
Cannabinoids for chronic pain
44
Chronic non-cancer pain treatment
45
Chronic pain treatment
46
Accessible treatment
Improved sleep
Reduced pain catastrophizing
Reduced pain intensity
47
IIPT for severe chronic pediatric pain
49
Multidisciplinary care
Opioid reduction
50
Opioid reduction
51
Improved quality of life
Reduced pain interference
52
Improved quality of life
Reduced chronic pain
53
Neuropathic pain treatment
54
Fibromyalgia treatment
55
Pain management
Treatment access
56
Risk Keywords
None mentioned
3
Side effects
5
Burning sensation
Cough
Dizziness
Dry eyes
Headache
Numbness
10
Anorexia
Depersonalization/derealization
Drowsiness
Hallucinations
Insobriety
Myoclonic movements
Nausea/vomiting
Sedation
Somnolence
Urinary retention
14
Myofascial pain syndrome
15
Chronic pain
Spinal cord injury
17
None reported
19
Opioid dependence
22
Chronic pain severity
24
Chronic pain
26
Dizziness
38
High attrition
42
Efficacy not well established
44
High pain prevalence
48
Literature analysis of 56 papers
Positive Content
54
Neutral Content
2
Negative Content
0
Article Type
26
12
28
21
56
2.

[Therapeutic results in chronic, non-malignant pain in patients treated at a Danish multidisciplinary pain center compared with general practice. A randomized controlled clinical trial].

Author: BeckerN, SjøgrenP, OlsenA K, EriksenJ

Improve HRQL
Reduce pain intensity

Multidisciplinary pain treatment (MPT) was found to be more effective than treatment by general practitioners after initial supervision by a pain specialist in reducing pain intensity and improving health-related quality of life (HRQL) in patients with chronic non-malignant pain.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Danish

3.

Manipulation and mobilization in the treatment of chronic pain.

Author: MiorS

Chronic low back pain relief
None mentioned

Manipulation and mobilization are more effective for chronic low back pain than placebos or usual care for up to 6 months. Evidence of effectiveness for chronic neck pain, chronic soft tissue shoulder disorders, and post-traumatic headache is limited.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Psychological therapies for the management of chronic and recurrent pain in children and adolescents.

Author: EcclestonC, YorkeL, MorleyS, WilliamsA C, MastroyannopoulouK

Treatment of chronic pain

More children are experiencing pain that lasts for six months or longer. While medications and physical therapy have been the main treatment approaches, psychological therapies are increasingly being used for children with chronic or recurrent pain, inspired by advancements in adult pain management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

The efficacy of oxycodone for management of acute pain episodes in chronic neck pain patients.

Author: MaK, JiangW, ZhouQ, DuD-P

Improved QOL
Improved QOS
Reduced pain episodes
Side effects

Oxycodone controlled release is a possible option for managing chronic neck pain with acute pain episodes in patients who have not responded to non-opioid conservative treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Psychometric testing and validation of the Chronic Pain Sleep Inventory.

Author: KosinskiMark, JanagapCarmela C, GajriaKavita, ScheinJeff

Sleep improvement

The Chronic Pain Sleep Inventory (CPSI) is a reliable and valid instrument for assessing sleep problems related to chronic pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Treatment of fibromyalgia syndrome with antidepressants: a meta-analysis.

Author: HäuserWinfried, BernardyKathrin, UçeylerNurcan, SommerClaudia

Fatigue reduction
Improved mood
Pain reduction
Quality of life improvement
Sleep improvement

Antidepressants are associated with improvements in pain, depression, fatigue, sleep disturbances, and health-related quality of life in patients with fibromyalgia syndrome (FMS).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews.

Author: KroenkeKurt, KrebsErin E, BairMatthew J

Chronic pain treatment

Chronic pain is a common, expensive, and disabling condition that is often not treated well. Chronic pain often occurs with depression, anxiety, and other mental health conditions, making these conditions harder to treat. This article provides evidence-based guidance on medication for managing chronic pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Fibromyalgia: Moderate and substantial pain intensity reduction predicts improvement in other outcomes and substantial quality of life gain.

Author: MooreAndrew R, StraubeSebastian, PaineJocelyn, PhillipsCeri J, DerrySheena, McQuayHenry J

Chronic pain treatment

This study investigated the relationship between pain intensity reduction and improvements in other symptoms in patients with fibromyalgia. It found that substantial and moderate pain reductions were associated with significant improvements in fatigue, function, sleep, depression, anxiety, work ability, general health status, and quality-adjusted life years (QALYs). The study suggests that pain reduction is a key predictor of overall improvement in fibromyalgia and that pain relief should be a target for continued treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Smoked cannabis for chronic neuropathic pain: a randomized controlled trial.

Author: WareMark A, WangTongtong, ShapiroStan, RobinsonAnn, DucruetThierry, HuynhThao, GamsaAnn, BennettGary J, ColletJean-Paul

Improved sleep
Reduced pain
Burning sensation
Cough
Dizziness
Dry eyes
Headache
Numbness

Inhalation of 9.4% tetrahydrocannabinol herbal cannabis reduced pain intensity, improved sleep, and was well-tolerated in patients with neuropathic pain. Further long-term safety and efficacy studies are recommended.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

[Long-term effects of interventional treatment on chronic pain of the musculoskeletal system. Retrospective outcome study of repeated in-patient treatment].

Author: NiemierK

Improved pain treatment

This study examines the long-term outcomes of repeated interventional treatment for chronic musculoskeletal pain, highlighting the limitations of current evidence for successful treatment in chronic cases.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

12.

The costs and consequences of adequately managed chronic non-cancer pain and chronic neuropathic pain.

Author: AndrewR, DerrySheena, TaylorRod S, StraubeSebastian, PhillipsCeri J

Chronic pain treatment

Chronic pain significantly impacts patients' lives and burdens healthcare systems and society. Recent studies highlight the negative effects of chronic pain and the positive benefits of successful treatment, making a review of the costs and consequences of chronic pain timely.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Effectiveness and cost-effectiveness of transmural collaborative care with consultation letter (TCCCL) and duloxetine for major depressive disorder (MDD) and (sub)chronic pain in collaboration with primary care: design of a randomized placebo-controlled multi-Centre trial: TCC:PAINDIP.

Author: de HeerEric W, DekkerJack, van Eck van der SluijsJonna F, BeekmanAartjan Tf, van MarwijkHarm Wj, HolwerdaTjalling J, BetPierre M, RothJoost, Hakkaart-Van RoijenLeona, RingoirLianne, KatFiona, van der Feltz-CornelisChristina M

Depression treatment
Pain management

Depression and pain often occur together and can make it difficult to treat either condition. This study will investigate the effectiveness and cost-effectiveness of an integrated treatment approach for patients with both depression and pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Ketamine for pain in adults and children with cancer: a systematic review and synthesis of the literature.

Author: BredlauAmy Lee, ThakurRajbala, KoronesDavid Nathan, DworkinRobert H

Pain reduction
Anorexia
Depersonalization/derealization
Drowsiness
Hallucinations
Insobriety
Myoclonic movements
Nausea/vomiting
Sedation
Somnolence
Urinary retention

Ketamine may be a viable option for treatment-refractory cancer pain in adults and children, although more research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Additional effects of transcranial direct-current stimulation and trigger-point injection for treatment of myofascial pain syndrome: a pilot study with randomized, single-blinded trial.

Author: ChoiYoon-Hee, JungSung-Jin, LeeChang Han, LeeShi-Uk

Trigger-point injection
tDCS
Myofascial pain syndrome

This research investigates the potential benefit of combining trigger-point injection (TPI) with transcranial direct-current stimulation (tDCS) for treating chronic pain caused by myofascial pain syndrome (MPS). tDCS is a neurostimulation technique that has shown promise in managing chronic pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Effects of whole body cryo-chamber therapy on pain in patients with chronic low back pain: a prospective double blind randomised controlled trial.

Author: NugrahaB, GüntherJ T, RawertH, SiegertR, GutenbrunnerC

Pain reduction

Cryochamber therapy with -67 °C is not superior to (sham cryo chamber) with -5 °C.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Non-pharmacological interventions for chronic pain in people with spinal cord injury.

Author: BoldtInga, Eriks-HooglandInge, BrinkhofMartin W G, de BieRob, JoggiDaniel, von ElmErik

Non-pharmacological interventions
Chronic pain
Spinal cord injury

This research examines non-pharmacological interventions for chronic pain in individuals with spinal cord injury (SCI). While medication is common, it can have side effects and may not be effective long-term. The study explores the potential benefits and harms of non-pharmacological treatments for SCI-related pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Effects of visual illusion and transcutaneous electrical nerve stimulation on neuropathic pain in patients with spinal cord injury: A randomised controlled cross-over trial.

Author: ÖzkulÇağla, KılınçMuhammed, YıldırımSibel Aksu, TopçuoğluElif Yalçın, AkyüzMüfit

Functional capacity
Pain reduction

Visual illusion (VI) and transcutaneous electrical nerve stimulation (TENS) therapies were effective in reducing pain intensity, pain quality, and functional limitations in patients with spinal cord injury (SCI) and neuropathic pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Evaluation of Stepped Care for Chronic Pain (ESCAPE) in Veterans of the Iraq and Afghanistan Conflicts: A Randomized Clinical Trial.

Author: BairMatthew J, AngDennis, WuJingwei, OutcaltSamantha D, SargentChristy, KempfCarol, FromanAmanda, SchmidArlene A, DamushTeresa M, YuZhangsheng, DavisLouanne W, KroenkeKurt

Reduced pain interference
Reduced pain severity
Reduced pain-related disability
None reported

A stepped-care intervention for veterans with chronic musculoskeletal pain, including analgesics, self-management strategies, and brief cognitive behavioral therapy, resulted in statistically significant reductions in pain-related disability, pain interference, and pain severity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

20.

Psychological therapies for the management of chronic neuropathic pain in adults.

Author: EcclestonChristopher, HearnLeslie, WilliamsAmanda C de C

Neuropathic pain relief

Neuropathic pain is caused by nerve damage and is becoming more common due to conditions like diabetes. While treatments for nerve pain are limited, this study investigates whether psychological therapy, which has shown benefits for managing pain in general, might also help people with chronic nerve pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

A randomized trial of a pain management intervention for adults receiving substance use disorder treatment.

Author: IlgenMark A, BohnertAmy S B, ChermackStephen, ConranCarly, JannauschMary, TraftonJodie, BlowFrederic C

Chronic pain treatment

This study evaluated the effectiveness of a pain management program called ImPAT for people with substance use disorders who also experience chronic pain. The program combines pain management strategies with information on how to manage pain without relying on substances.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Novel Three-Day, Community-Based, Nonpharmacological Group Intervention for Chronic Musculoskeletal Pain (COPERS): A Randomised Clinical Trial.

Author: TaylorStephanie J C, CarnesDawn, HomerKate, KahanBrennan C, HounsomeNatalia, EldridgeSandra, SpencerAnne, PincusTamar, RahmanAnisur, UnderwoodMartin

Chronic pain treatment
Opioid dependence

Chronic muscle and joint pain is a major cause of disability worldwide. While medications are often used to treat pain, their effectiveness is limited and they can have side effects, including addiction to opioids. This study looks at the effectiveness of a new group intervention program designed to help manage chronic muscle and joint pain without relying on medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Does Duration of Neuropathic Pain Impact the Effectiveness of Pregabalin?

Author: PérezConcepción, LatymerMark, AlmasMary, OrtizMarie, ClairAndrew, ParsonsBruce, VarvaraRoxana

Effective treatment
Improved pain

Pregabalin significantly improves pain in patients with neuropathic pain regardless of the duration of pain. This was found in a pooled analysis of 19 randomized placebo-controlled trials involving 5,783 patients with neuropathic pain conditions. Pregabalin was effective in improving pain and increasing Patient Global Impression of Change (PGIC) responders in all pain duration categories, without significant differences in treatment response between these categories.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

24.

Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews.

Author: GeneenLouise J, MooreR Andrew, ClarkeClare, MartinDenis, ColvinLesley A, SmithBlair H

Chronic pain treatment
Chronic pain severity

This review discussed the growing evidence supporting the use of exercise programs for managing chronic pain, highlighting their potential benefits for reducing pain severity and improving overall health.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Does Conservative Treatment Change the Brain in Patients with Chronic Musculoskeletal Pain? A Systematic Review.

Author: KregelJeroen, CoppietersIris, DePauwRobby, MalflietAnneleen, DanneelsLieven, NijsJo, CagnieBarbara, MeeusMira

This study discussed the potential of cognitive, exercise, and multimodal therapies for rehabilitating patients with chronic musculoskeletal pain, acknowledging the maladaptive central neuroplastic changes associated with chronic pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews.

Author: GeneenLouise J, MooreR Andrew, ClarkeClare, MartinDenis, ColvinLesley A, SmithBlair H

Improved functioning
Improved health
Reduced pain severity
Chronic pain

This review discussed the growing evidence supporting the use of exercise programs for managing chronic pain, highlighting their potential benefits for reducing pain severity and improving overall health.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

[Effectiveness of education based on neuroscience in the treatment of musculoskeletal chronic pain].

Author: Cuenda-GagoJ D, Espejo-AntunezL

Pain neuroscience education

This systematic review examined the effectiveness of pain neuroscience education in the treatment of musculoskeletal disorders with chronic pain. The results suggest that pain neuroscience education is effective in the short term and medium/long term for pain relief.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Spanish

28.

Systematic review of management of chronic pain after surgery.

Author: WyldeV, DennisJ, BeswickA D, BruceJ, EcclestonC, HowellsN, PetersT J, Gooberman-HillR

This systematic review examines the effectiveness and safety of interventions for chronic postsurgical pain (CPSP). The study analyzes data across treatment types to determine their effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Antidepressants for chronic non-cancer pain in children and adolescents.

Author: CooperTess E, HeathcoteLauren C, ClinchJacqui, GoldJeffrey I, HowardRichard, LordSusan M, SchechterNeil, WoodChantal, WiffenPhilip J

Improved neuropathic pain
Pain relief

This review examines the use of antidepressants for treating chronic non-cancer pain in children. The study explores the evidence for using antidepressants in this population and the need for further research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

Cannabis-based medicines for chronic neuropathic pain in adults.

Author: MückeMartin, PhillipsTudor, RadbruchLukas, PetzkeFrank, HäuserWinfried

Reduced pain

Cannabis, while used for centuries to reduce pain, is being promoted as a treatment for chronic neuropathic pain, despite limited evidence supporting its effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Interdisciplinary team-based care for patients with chronic pain on long-term opioid treatment in primary care (PPACT) - Protocol for a pragmatic cluster randomized trial.

Author: DeBarLynn, BenesLindsay, BonifayAllison, DeyoRichard A, ElderCharles R, KeefeFrancis J, LeoMichael C, McMullenCarmit, MayhewMeghan, Owen-SmithAshli, SmithDavid H, TrinactyConnie M, VollmerWilliam M

Reduced pain impact

This study described a pragmatic clinical trial investigating the effectiveness of an interdisciplinary biopsychosocial intervention, the Pain Program for Active Coping and Training (PPACT), in reducing pain impact for patients with chronic pain in primary care settings.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

32.

Is sleep disturbance in patients with chronic pain affected by physical exercise or ACT-based stress management? - A randomized controlled study.

Author: WiklundTobias, LintonSteven J, AlföldiPeter, GerdleBjörn

Improved chronic pain treatment
Improved sleep

Chronic pain often leads to sleep problems. Cognitive behavioral therapy (CBT) is a promising treatment for insomnia alongside chronic pain, but access to CBT is often limited. New interventions focusing on improving cognitive flexibility and increasing physical activity could be effective treatments for both insomnia and chronic pain. If proven effective, these interventions could become the first step in a stepped care model for managing these conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

Patients With Chronic Spinal Pain Benefit From Pain Neuroscience Education Regardless the Self-Reported Signs of Central Sensitization: Secondary Analysis of a Randomized Controlled Multicenter Trial.

Author: MalflietAnneleen, KregelJeroen, MeeusMira, DanneelsLieven, CagnieBarbara, RousselNathalie, NijsJo

Improved kinesiophobia
Reduced illness perception
Reduced pain catastrophizing

Pain neuroscience education was found to be beneficial for all patients with chronic spinal pain, improving kinesiophobia and perceived negative consequences of the illness. However, it was more effective in reducing pain catastrophizing in patients with high self-reported symptoms of central sensitization.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Association Between Psychological Interventions and Chronic Pain Outcomes in Older Adults: A Systematic Review and Meta-analysis.

Author: NiknejadBahar, BolierRuth, HendersonCharles R, DelgadoDiana, KozlovElissa, LöckenhoffCorinna E, ReidM Carrington

Improved self-efficacy
Reduced pain

Psychological interventions, particularly those delivered in group settings, had small benefits for chronic pain in older adults, including reducing pain and catastrophizing beliefs and improving pain self-efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Transcutaneous electrical nerve stimulation (TENS) for chronic pain - an overview of Cochrane Reviews.

Author: GibsonWilliam, WandBenedict M, MeadsCatherine, CatleyMark J, O'ConnellNeil E

Chronic pain treatment
TENS

Chronic pain, lasting more than three months, is common and difficult to treat. While medications and non-medication therapies are often used, transcutaneous electrical nerve stimulation (TENS) is a common additional treatment recommended by doctors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

[Osteopathy for chronic pain after breast cancer surgery: A monocentric randomised study].

Author: ChvetzoffGisèle, BerthierAudrey, BlancEllen, Bourne BranchuValérie, MillaretAnne, CropetClaire, PérolDavid

Improved quality of life
Reduced depression

Osteopathy may improve quality of life and reduce depression in breast cancer patients with chronic pain. While there was no difference in pain scores between the osteopathy and standard analgesic treatment groups, the osteopathy group showed improvement in overall quality of life and reduced depression scores.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

37.

A Systematic Review of Economic Evaluation Studies of Drug-Based Non-Malignant Chronic Pain Treatment.

Author: BackhausInsa, MannocciAlice, La TorreGiuseppe

Improved chronic pain treatment

This systematic review assessed the economic evaluations of pharmacological treatments for non-malignant chronic pain, comparing different approaches based on their economic profile.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Gabapentin for the management of chronic pelvic pain in women.

Author: AbdelHafeezM A, RedaA, ElnaggarA, El-ZeneinyH, MokhlesJ M

Reduced chronic pelvic pain
Dizziness

Oral gabapentin effectively reduced chronic pelvic pain (CPP) in women compared to placebo. A significantly higher proportion of patients in the gabapentin group experienced a 30% or more reduction in pain scores at 24 weeks. The most common adverse effect of gabapentin was dizziness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

39.

Necessary components of psychological treatment in pain management programs: A Delphi study.

Author: SharpeLouise, JonesEmma, Ashton-JamesClaire E, NicholasMichael K, RefshaugeKathryn

Chronic pain management

A Delphi study was conducted to reach a consensus on necessary and desirable psychological intervention strategies for chronic pain management. The experts agreed that psycho-education, approaches to increase activity, and cognitive approaches are essential for effective treatment. Other desirable strategies were also identified.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Psychological therapies for the management of chronic pain (excluding headache) in adults.

Author: WilliamsAmanda C de C, FisherEmma, HearnLeslie, EcclestonChristopher

Chronic non-cancer pain treatment

Chronic pain that isn't caused by cancer is a common and debilitating problem, affecting many adults and placing a strain on healthcare systems. Therapy aims to reduce pain, disability, and distress. This review updates previous research on this topic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Prescription of exercises for the treatment of chronic pain along the continuum of nociplastic pain: A systematic review with meta-analysis.

Author: Ferro Moura FrancoKatherinne, LenoirDorine, Dos Santos FrancoYuri Rafael, Jandre ReisFelipe José, Nunes CabralCristina Maria, MeeusMira

Exercise for chronic pain

A systematic review was conducted to compare different exercise prescriptions for patients with chronic pain along the continuum of nociplastic pain: fibromyalgia, chronic whiplash-associated disorders (CWAD), and chronic idiopathic neck pain (CINP). The study found that low to moderate intensity global exercises performed for a long period of treatment should be performed in patients with nociplastic pain predominance. Additionally, focused and intense exercises for a short period of treatment can be prescribed for patients with nociceptive pain predominance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Internet-Based Multimodal Pain Program With Telephone Support for Adults With Chronic Temporomandibular Disorder Pain: Randomized Controlled Pilot Trial.

Author: LamJulia, SvenssonPeter, AlstergrenPer

Jaw function
Occlusal splint effect
High attrition

An internet-based multimodal pain program did not demonstrate a significant difference in treatment outcome compared to occlusal splint therapy in patients with chronic temporomandibular pain. However, the program improved jaw function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

Effect of Electroacupuncture vs Sham Treatment on Change in Pain Severity Among Adults With Chronic Low Back Pain: A Randomized Clinical Trial.

Author: KongJiang-Ti, PuetzChelcie, TianLu, HaynesIsaac, LeeEunyoung, StaffordRandall S, ManberRachel, MackeySean

Chronic low back pain reduction

This randomized clinical trial found no statistically significant difference in change in PROMIS pain score in real electroacupuncture vs sham electroacupuncture. However, there was a statistically significant treatment effect for the secondary outcome of RMDQ compared with sham electroacupuncture. Effective coping skills and non-White race were associated with response to electroacupuncture.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

44.

Cannabis for Chronic Pain: A Rapid Systematic Review of Randomized Control Trials.

Author: LongoRiana, OudshoornAbe, BefusDeanna

Cannabinoids for chronic pain
Efficacy not well established

This review examines the use of cannabinoids for the treatment of chronic pain, highlighting the need for further research to establish their efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Efficacy of a combination of hypnosis and transcutaneous electrical nerve stimulation for chronic non-cancer pain: A randomized controlled trial.

Author: Tonye-GeoffroyLouise, Mauboussin CarlosStéphanie, TuffetSophie, FromentinHélène, BerardLaurence, LeblancJudith, LarocheFrançoise

Chronic non-cancer pain treatment

Chronic pain that's not caused by cancer can severely impact quality of life. Many different treatments are used, including medication and non-medication approaches. Nurses in France often use transcutaneous electrical nerve stimulation (TENS) and hypnosis to treat chronic pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

46.

Neuromodulation for Pain: A Comprehensive Survey and Systematic Review of Clinical Trials and Connectomic Analysis of Brain Targets.

Author: YamamotoKazuaki, EliasGavin J B, BeynMichelle E, ZemmarAjmal, LohAaron, SaricaCan, GermannJürgen, ParmarRoohie, WongEmily H Y, BoutetAlexandre, KaliaSuneil, HodaieMojgan, LozanoAndres M

Chronic pain treatment

Chronic pain is a major problem, and while medication and therapy are often used, some people don't find relief. This study examines different ways to stimulate the nervous system (neuromodulation) to treat chronic pain. The study explores the various types of neuromodulation and how they work, highlighting the need for more research to understand these approaches better.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

Pain Prevalence During Cancer Treatment: A Systematic Review and Meta-Analysis.

Author: EvenepoelMargaux, HaenenVincent, De BaerdemaeckerTom, MeeusMira, DevoogdtNele, DamsLore, Van DijckSophie, Van der GuchtElien, De GroefAn

High pain prevalence

Pain prevalence during cancer treatment was found to be 40% (95% CI 0.29-0.51) in a meta-analysis of 12 studies, with a high degree of heterogeneity. The heterogeneity was partially explained by the method of pain measurement.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Effectiveness of a Psychosocial Aftercare Program for Youth Aged 8 to 17 Years With Severe Chronic Pain: A Randomized Clinical Trial.

Author: DoganMeltem, HirschfeldGerrit, BlankenburgMarkus, FrühwaldMichael, AhnertRosemarie, BraunSarah, MarschallUrsula, PfenningIngo, ZernikowBoris, WagerJulia

IIPT for severe chronic pediatric pain

Intensive interdisciplinary pain treatment (IIPT) is an established treatment for severe chronic pediatric pain. However, IIPT is not effective for all patients, highlighting the need for additional treatment options to address this widespread and debilitating condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

Opioid reduction for patients with chronic pain in primary care: systematic review.

Author: de KleijnLoes, PedersenJulie Rønne, Rijkels-OttersHanneke, ChiarottoAlessandro, KoesBart

Multidisciplinary care
Opioid reduction

This systematic review of controlled trials and cohort studies found that GP-supervised tapering and multidisciplinary group therapeutic sessions may be effective strategies for reducing long-term opioid treatment for patients with chronic non-cancer pain. However, due to the high risk of bias and small sample sizes of the included studies, no firm conclusions can be made.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

Organizational changes lead to a reduction in opioid consumption among chronic pain patients: A systematic review.

Author: BacheNina, GeislerAnja

Opioid reduction

A systematic review of 11 studies on organizational changes in pain treatment for patients with chronic nonmalignant pain found that implementing new follow-up procedures resulted in a reduction in opioid consumption.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Effect of Ear Acupuncture plus Dry Cupping on Activities and Quality of Life in the Adults with Chronic Back Pain: a Randomized Trial.

Author: MouraCaroline de Castro, ChavesErika de Cássia Lopes, NogueiraDenismar Alves, IunesDenise Hollanda, AzevedoCissa, CorrêaHérica Pinheiro, PereiraGabriela Aparecida, SilvanoHigor Magalhães, MacieiraTamara Goncalves Rezende, ChiancaTânia Couto Machado

Improved quality of life
Reduced pain interference

Ear acupuncture combined with dry cupping therapy showed greater improvement in quality of life and satisfaction with health compared to ear acupuncture alone in patients with chronic back pain. A randomized controlled trial found significant improvements in daily activities, mood, relationships, and sleep for both groups. However, the experimental group reported greater satisfaction with health and a better perception of quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

Patient-Centered Pain Care Using Artificial Intelligence and Mobile Health Tools: A Randomized Comparative Effectiveness Trial.

Author: PietteJohn D, NewmanSean, KreinSarah L, MarinecNicolle, ChenJenny, WilliamsDavid A, EdmondSara N, DriscollMary, LaChappelleKathryn M, KernsRobert D, MalyMarianna, KimH Myra, FarrisKaren B, HigginsDiana M, ButaEugenia, HeapyAlicia A

Improved quality of life
Reduced chronic pain

An AI-powered CBT-CP program was noninferior to therapist-delivered telephone CBT-CP for chronic back pain and required significantly less therapist time. This approach could improve access to CBT-CP for more patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

54.

The core of maintaining neuropathic pain: Crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord).

Author: ZhangTianrui, ZhangMingqian, CuiShuang, LiangWulin, JiaZhanhong, GuoFanfan, OuWenjing, WuYonghong, ZhangShuofeng

Neuropathic pain treatment

This study focuses on neuropathic pain (NP), a chronic pain condition caused by nerve damage or dysfunction. The study investigates the role of pro-inflammatory factors and chemokines in mediating hyperalgesia, a hallmark of NP.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

55.

Green Light-Based Analgesia - Novel Nonpharmacological Approach to Fibromyalgia Pain: A Pilot Study.

Author: NelliAmanda, WrightMary Cooter, GulurPadma

Fibromyalgia treatment

This study examines the use of opioids for managing chronic pain, specifically focusing on fibromyalgia. Opioids are commonly used for fibromyalgia but can be misused. The study emphasizes the need for opioid-sparing multimodal analgesic strategies, including nonopioid pain relievers and green-light therapy.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

56.

Psychological therapies delivered remotely for the management of chronic pain (excluding headache) in adults.

Author: RosserBenjamin A, FisherEmma, JanjuaSadia, EcclestonChristopher, KeoghEdmund, DugganGeoffrey

Pain management
Treatment access

Chronic pain, lasting over three months, is a significant problem. Traditional treatments can be difficult to access due to limited resources, location, and cost. This study looks at the potential of using technology to deliver psychological therapies for chronic pain remotely. The goal is to see if online therapy is as effective as in-person therapy for managing chronic pain.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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