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Low-Dose Methotrexate Toxicity Presenting as Pancytopenia.

Author: AhmedBirjees, ChauhanSukhjinder, DhillonGundip S, GhobrialYoussef, JalalYema

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

This case report presents an 82-year-old woman with severe pancytopenia induced by low-dose methotrexate (MTX). The patient was treated with leucovorin rescue therapy and granulocyte colony-stimulating factor (G-CSF) therapy. This case highlights the importance of monitoring for potential side effects even with low-dose MTX treatment.
Paper Details　
Original Abstract of the Article :
High-dose methotrexate (MTX, 5 g/week) is typically used for the treatment of different malignancies and may be associated with serious side effects, such as acute kidney injury, myelosuppression, and hepatotoxicity. On the other hand, low-dose MTX (10-25 mg/week) is considered to be a safe and effe...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840410/

データ提供：米国国立医学図書館（NLM）

A Rare Encounter: Low-Dose Methotrexate Toxicity

This case report explores a [rare but serious complication] associated with [low-dose methotrexate (MTX) therapy]. The researchers describe a case of [MTX-induced pancytopenia], a condition characterized by [a significant decrease in all blood cell types]. This report emphasizes the [importance of recognizing and managing] this potential side effect of low-dose MTX.

Understanding the Unexpected: Low-Dose MTX Toxicity

This case report [highlights the importance of being vigilant] when [prescribing low-dose MTX] and [monitoring patients closely] for [signs of potential complications]. This study serves as a [cautionary tale], reminding us that [even seemingly safe medications can have unexpected side effects]. This research is like a [desert mirage], revealing the [hidden dangers] lurking beneath the surface of seemingly innocuous treatments.

A Timely Reminder: Navigating Low-Dose MTX Therapy

This case report [offers valuable insights] for [clinicians managing patients on low-dose MTX]. The report emphasizes the [importance of timely diagnosis and treatment] to [mitigate the potential risks] associated with this medication. This research is like a [desert compass], guiding us [towards safer and more effective treatment approaches] for patients on low-dose MTX.

Dr.Camel's Conclusion

This case report [serves as a timely reminder] of the [importance of recognizing and managing] the [potential complications] of [even low-dose medications]. It emphasizes the [need for vigilance] and [proactive management] to [ensure patient safety]. This research is like a [desert oasis], [providing valuable insights] for [safe and effective treatment] of patients [receiving low-dose MTX].

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-01-20
Further Info :

Pubmed ID

36654616

DOI: Digital Object Identifier

PMC9840410

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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